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Sarah Hrebien, Ben O’Leary, Matthew Beaney, Gaia Schiavon, Charlotte Fribbens, Amarjit Bhambra, Richard Johnson, Isaac Garcia-Murillas, Nicholas Turner
Reproducibility of Digital PCR Assays for Circulating Tumor DNA Analysis in Advanced Breast Cancer
www.plosone.org
www.plosone.org
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[()-9()1()2()12()-5()7()8()]TJ
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[()]TJ
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[()-5()8()-10()-5()2()12()-5()8( )19()]TJ
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7.6478 0 Td
[(")-3()-4()12()10()6()1( )]TJ
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[()1( )]TJ
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[(7)16()8()7()-7()2()1( )]TJ
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[(.)25()1()5()11()12()-6()-4()]TJ
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[(=,7.>)]TJ
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[(,)-3()2()-7()-5()8()13()6()]TJ
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[(")1()1()]TJ
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[()15()]TJ
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[(?)8()13()11()-5()2()-9(\(@)-9()11( )4()2()11( )]TJ
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[(,)-3()2()-7()-5()8()13()6()]TJ
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[(+)22()-4()2()2()-1()]TJ
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[()-16()11()2()2()12()10()6()-6()]TJ
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[()13()1()8()1()13()1( )4()-1()]TJ
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[()25(<)]TJ
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[(\);.\)/\) ; \))]TJ
5.4651 0 Td
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[()-4()4()]TJ
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[(,)-3()15()1()-4()]TJ
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[(.)25()1()5()11()12()-6()-4()]TJ
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[(,)-3()2()-7()-5()8()13()6()]TJ
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[()25(<)]TJ
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0.83 0.64 0.02 0 k
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[()]TJ
0 g
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[(")8()1()13()]TJ
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[()-1()6()-5()2()-6()-6()6()-6()]TJ
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[()]TJ
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[()-5()]TJ
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[(B)]TJ
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[()-1()6()-5()2()-6()-6()-5()2()11( )]TJ
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[()-5()]TJ
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[(:)14()-5()13()-6()6(#)]TJ
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[()-16()5()-5(\(0)17()13()-6()]TJ
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[(\r)9()37()]TJ
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[()-1()6()-5()2()-6()-6()-5()2()11( )]TJ
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[()10()5()-9()]TJ
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[()8()6()-5()2()15(")-3()1( )8(\n)]TJ
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[()3()8( )19()1()-1()2()-6()10()1()13()1()15(C)93()]TJ
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[()13()-6()-1()11()2()4()1( )4()-2(\()]TJ
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[()-5()2()11( )8()]TJ
2.4094 0 Td
[(:)14()-5()13()-6()6(#)]TJ
2.6815 0 Td
[()10()5()-9()2()]TJ
2.3244 0 Td
[(")8()1()13()]TJ
2.0977 0 Td
[()5()2()12()11()-9()-6()]TJ
3.3562 0 Td
[()11( )]TJ
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[()11()2()6()2()1(\n)-5()2()-3()-4()]TJ
4.0592 0 Td
[()5()-9()-6()1()4()1( )]TJ
3.9685 0 Td
[()-1()11( )19()-6()8()1( )4()1()7()]TJ
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[()18()]TJ
0.9637 0 Td
[()8()10()11()2()1( )19()]TJ
3.4923 0 Td
[()6()1()19()-9()1()18()10()1()13()]TJ
5.0967 0 Td
[()6()]TJ
1.0261 0 Td
[()]TJ
-37.1109 -1.3039 Td
[()-1()1( )19()-5()-4()]TJ
2.948 0 Td
[()-2()9()]TJ
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[()8()11()]TJ
1.3776 0 Td
[()11()13()-9()-1()2()5()2()1( )8(\n)-3()]TJ
4.6488 0 Td
[(5)97()5()-9()2()]TJ
2.6419 0 Td
[()6()-9()6(#)]TJ
2.0126 0 Td
[()-9()1()-2(")8()-6()1( )]TJ
3.4922 0 Td
[(2/)]TJ
1.1793 0 Td
[()8( )4()]TJ
1.7234 0 Td
[(%)]TJ
1.1792 0 Td
[()4()11()1()7()]TJ
2.5002 0 Td
[()6()]TJ
1.0261 0 Td
[()8()-4()-4()7()8()]TJ
2.5228 0 Td
[()18()]TJ
0.9581 0 Td
[()-4()4()]TJ
1.474 0 Td
[()-1()1( )19()-5()-4()]TJ
2.9537 0 Td
[()11()13()-9()-1()2()5(\()]TJ
-34.0495 -1.2983 Td
[()1( )8(\n)]TJ
1.4796 0 Td
[()-2()9()]TJ
1.4117 0 Td
[()8( )4()]TJ
1.7178 0 Td
[(")8()1()13()]TJ
2.0976 0 Td
[()11()13()-9()-1()2()5()-7()-6()]TJ
4.1102 0 Td
[()11( )4()-1()]TJ
2.0976 0 Td
[()13()-6()-1()1()7()8()-6()6()]TJ
ET
Q
q
1 j
1 J
0 w
11.9999 0 0 11.9999 200.0125 178.0157 cm
BT
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1 TL
0 0 Td
(Processing)Tj
5.1401 0 Td
(of)Tj
1.0536 0 Td
(plasma)Tj
3.4252 0 Td
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(extraction)Tj
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(cfDNA)Tj
ET
Q
q
1 j
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10 0 0 10 200.0125 161.0078 cm
BT
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1 TL
0 0 Td
[(?)6()2()-9()-9()]TJ
2.5738 0 Td
[()-1()6()-5()2()-6()-6()6()-6()]TJ
3.7134 0 Td
[()1( )]TJ
1.0261 0 Td
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2.8119 0 Td
[(B)]TJ
1.3663 0 Td
[()10()5()-9()2()]TJ
2.3301 0 Td
[(")1()1()]TJ
1.7008 0 Td
[()11()13()-9()-1()2()5()-7()-6()]TJ
4.1045 0 Td
[(")-3()12()-4()2()1( )]TJ
2.8006 0 Td
[()-2(")8()]TJ
1.7008 0 Td
[()4()11()1()7()]TJ
2.5001 0 Td
[()11()]TJ
1.0148 0 Td
[()-6()8()19()6()2()]TJ
3.0218 0 Td
[()-1()6()-5()2()-6()-6()-5()2()11( )]TJ
4.2972 0 Td
[(")-7()2()-5()2()]TJ
-34.9622 -1.2982 Td
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2.4944 0 Td
[()-1()6()-5()2()-6()-6()6()-6()]TJ
3.7077 0 Td
[()1( )]TJ
1.0262 0 Td
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2.6815 0 Td
[()-16()5()-5(\(0)17()13()-6()]TJ
3.8664 0 Td
[(\r)9()37()]TJ
2.3811 0 Td
[()10()5()-9()2()]TJ
2.3244 0 Td
[(")1()1()]TJ
1.7008 0 Td
[()11()13()-9()-1()2()5()-7()-6()]TJ
4.1102 0 Td
[(2/%)]TJ
2.6476 0 Td
[()4()11()1()7()]TJ
2.5058 0 Td
[()8()-7()6()1()]TJ
2.0296 0 Td
[()-1()6()-5()2()-6()-6()-5()2()11( )]TJ
-31.4757 -1.3039 Td
[(?)6()2()-9()-9()]TJ
2.5738 0 Td
[(")1()1()]TJ
1.7008 0 Td
[()-1()1( )19()-5()-4()1()-7()1(\n)7()-6()]TJ
4.7338 0 Td
[()18()]TJ
0.9638 0 Td
[($\)\))]TJ
2.1373 0 Td
[(\n)]TJ
0.6803 0 Td
[()8()11()]TJ
1.3776 0 Td
[(\))]TJ
1.1792 0 Td
[()2()1( )19()12()6()2()]TJ
3.4413 0 Td
[()8( )4()]TJ
1.7177 0 Td
[()6()-2()1()2()3()]TJ
3.0501 0 Td
[()-7()1()-5()8()18()6()-6()]TJ
4.0025 0 Td
[()3()2()1( )8(\n)]TJ
2.3698 0 Td
[()8()1()]TJ
1.2812 0 Td
[()1()3()5()6()-2()2()-1()1()4()1( )19()]TJ
-31.2092 -1.2983 Td
[()11()12()-9()1()10()6()2()]TJ
3.5432 0 Td
[()2()-5()18()-3()1( )8(\n)]TJ
3.0444 0 Td
[(\) )]TJ
1.8822 0 Td
[()-5()]TJ
1.2813 0 Td
[()9()-9()15()8()]TJ
2.5341 0 Td
[()-4()4()]TJ
1.474 0 Td
[()11()1()-11()-17()]TJ
2.2847 0 Td
[()-1()-5()18()]TJ
1.8766 0 Td
[()-2()18()8()1()64()]TJ
2.3697 0 Td
[(-)6()-2()1()2()3()]TJ
3.0841 0 Td
[(")1()1()]TJ
1.7008 0 Td
[()5()6()11()13()-6()]TJ
2.6929 0 Td
[()18()]TJ
0.9581 0 Td
[(\(/\)D)]TJ
2.5228 0 Td
[()1( )19()-5()-5()]TJ
2.0976 0 Td
[(\r)9()37()]TJ
-33.3465 -1.2983 Td
[()2(6)-5()2()-6()-5()2()11( )]TJ
4.4503 0 Td
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3.0898 0 Td
[(")1()1()]TJ
1.7007 0 Td
[()2(6)-5()2()-6()6()-6()]TJ
3.8665 0 Td
[()-11()13()11()]TJ
2.194 0 Td
[()]TJ
0.6973 0 Td
[()-5()]TJ
1.2812 0 Td
[()11()]TJ
1.0148 0 Td
[()6()-2()1()2()3()]TJ
3.0444 0 Td
[()3()2()1( )8(\n)]TJ
2.3698 0 Td
[()-4()4()]TJ
1.4683 0 Td
[(E)9(!)38()12()8()19()]TJ
3.7587 0 Td
[()1()13()-6()-5()-2()18()-5()1( )8(\n)]TJ
4.4504 0 Td
[( )19()2()6()2()1()2()]TJ
-33.3862 -1.3039 Td
[()2()2()]TJ
1.8538 0 Td
[(#)-4()12()]TJ
1.2756 0 Td
[(=E)1()-2()6(\n)7()1( >)]TJ
3.7644 0 Td
[()2()-1()-1()11()13()1()1( )8(\n)]TJ
4.1385 0 Td
[()6()]TJ
1.0262 0 Td
[()-4()4()]TJ
1.4683 0 Td
[()3()8( )19()1()-1()2()-6()10()1()13()1()15(C)93()]TJ
6.2362 0 Td
[()1( )8()5()-5()-10()2()-6()-5()2()11( )8()]TJ
5.1817 0 Td
[(5)1()4()]TJ
1.7858 0 Td
[(\r)9()37()]TJ
3.0897 0 Td
[(")1()1()]TJ
1.7008 0 Td
[()5()12()12()6()-6()]TJ
2.6476 0 Td
[()1( )19()6()]TJ
-34.1686 -1.2982 Td
[( \))]TJ
1.1792 0 Td
[(F)]TJ
0.9807 0 Td
[()11()1()-11()8()1()]TJ
2.6079 0 Td
[()96(G+)]TJ
2.1713 0 Td
[()8( )4()]TJ
1.7178 0 Td
[()5()6()11()13()-6()]TJ
2.6929 0 Td
[()18()]TJ
0.9581 0 Td
[(\(\)D)]TJ
2.5228 0 Td
[()1()]TJ
1.0262 0 Td
[()11()13()-9()-3()2()11()3()5()7()]TJ
4.3369 0 Td
[()2()2()-7()-4()5()-9()-6()]TJ
4.0082 0 Td
[()]TJ
0.83 0.64 0.02 0 k
[(2)]TJ
0 g
[()]TJ
0.83 0.64 0.02 0 k
1.2586 0 Td
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0 g
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ET
Q
q
1 j
1 J
0 w
576 737.1 m
36 737.1 l
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576 737.6 l
f*
36 741.2598 107.1496 23.6976 re
W* n
q
107.0929 0 0 23.6409 36 741.3165 cm
q
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Q
Q
Q
q
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BT
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ET
Q
q
1 j
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36 48.0002 m
576 48.0002 l
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36 47.5002 l
f*
7.9999 0 0 7.9999 36 36 cm
BT
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37.5239 0 Td
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