Browsing by author "Howard, Beatrice"
Now showing items 1-17 of 17
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A mouse SWATH-mass spectrometry reference spectral library enables deconvolution of species-specific proteomic alterations in human tumour xenografts.
Krasny, L; Bland, P; Burns, J; Lima, NC; Harrison, PT; et al. (COMPANY BIOLOGISTS LTD, 2020-06-03)SWATH-mass spectrometry (MS) enables accurate and reproducible proteomic profiling in multiple model organisms including the mouse. Here, we present a comprehensive mouse reference spectral library (MouseRefSWATH) that ... -
A Sox2-Sox9 signalling axis maintains human breast luminal progenitor and breast cancer stem cells.
Domenici, G; Aurrekoetxea-Rodríguez, I; Simões, BM; Rábano, M; Lee, SY; et al. (Springer Science and Business Media LLC, 2019-04-25)Increased cancer stem cell content during development of resistance to tamoxifen in breast cancer is driven by multiple signals, including Sox2-dependent activation of Wnt signalling. Here, we show that Sox2 increases and ... -
Cdk5 phosphorylation of ErbB4 is crucial for cortical interneuron migration
Rakic, S; Kanatani, S; Hunt, D; Faux, C; Cariboni, C; et al.Interneuron dysfunction is often associated with neurological and psychiatric disorders, such as epilepsy, schizophrenia and autism. Some of these disorders arise during brain formation, at the time of interneuron ... -
Comparative proteomic assessment of matrisome enrichment methodologies.
Krasny, L; Paul, A; Wai, P; Howard, BA; Natrajan, RC; et al. (PORTLAND PRESS LTD, 2016-11-01)The matrisome is a complex and heterogeneous collection of extracellular matrix (ECM) and ECM-associated proteins that play important roles in tissue development and homeostasis. While several strategies for matrisome ... -
Ectodysplasin target gene Fgf20 regulates mammary bud growth and ductal invasion and branching during puberty
Howard, B; elo, T; lindfors, P; lan, Q; voutilainen, M; et al. -
ENBDC turned 10 years, a growing family of mammary gland researchers
Koledova, Z; Howard, B; Englund, J; Bach, K; Bentires-Alj, M; et al. -
Mammary lineage restriction in development
Bland, P; Howard, B -
Neuregulin-3 regulates epithelial progenitor cell positioning and specifies mammary phenotype.
Kogata, N; Oliemuller, E; Wansbury, O; Howard, BA (MARY ANN LIEBERT, INC, 2014-11-15)Mutation of Neuregulin-3 (Nrg3) results in defective embryonic mammary gland development. Here, we investigate functions of Nrg3 signaling in embryonic mammary morphogenesis. Nrg3 regulates the distribution of epithelial ... -
Regulatory roles for SOX11 in development, stem cells and cancer
Tsang, SM; Oliemuller, E; Howard, BA (Elsevier BV, 2020-12-01) -
Signalling pathways implicated in early mammary gland morphogenesis and breast cancer.
Howard, B; Ashworth, A (PUBLIC LIBRARY SCIENCE, 2006-08-01)Specification of mammary epithelial cell fate occurs during embryogenesis as cells aggregate to form the mammary anlage. Within the embryonic mammary bud, a population of epithelial cells exists that will subsequently ... -
SOX11 promotes epithelial/mesenchymal hybrid state and alters tropism of invasive breast cancer cells.
Oliemuller, E; Newman, R; Tsang, SM; Foo, S; Muirhead, G; et al. (eLife Sciences Publications, Ltd, 2020-09-10)SOX11 is an embryonic mammary epithelial marker that is normally silenced prior to birth. High SOX11 levels in breast tumours are significantly associated with distant metastasis and poor outcome in breast cancer patients. ... -
SOX11 promotes invasive growth and ductal carcinoma in situ progression.
Oliemuller, E; Kogata, N; Bland, P; Kriplani, D; Daley, F; et al. (WILEY, 2017-10-01)Here, we show that SOX11, an embryonic mammary marker that is normally silent in postnatal breast cells, is expressed in many oestrogen receptor-negative preinvasive ductal carcinoma in situ (DCIS) lesions. Mature mammary ... -
Sox11 regulates mammary tumour-initiating and metastatic capacity in Brca1-deficient mouse mammary tumour cells.
Tsang, SM; Kim, H; Oliemuller, E; Newman, R; Boateng, N-A; et al. (COMPANY BIOLOGISTS LTD, 2021-05-01)Little is known about the role of Sox11 in the regulation of mammary progenitor cells. Sox11 is expressed by mammary bud epithelial cells during embryonic mammary gland development and is not detected in mammary epithelial ... -
Sox9 regulates cell state and activity of embryonic mouse mammary progenitor cells.
Kogata, N; Bland, P; Tsang, M; Oliemuller, E; Lowe, A; et al. (2018-01)Embryonic mammary cells are a unique population comprised of undifferentiated, highly plastic progenitor cells that create normal mammary tissues. The mammary gland continues to develop after birth from descendants of ... -
Sox9 regulates cell state and activity of embryonic mouse mammary progenitor cells.
Kogata, N; Bland, P; Tsang, M; Oliemuller, E; Lowe, A; et al. (NATURE PUBLISHING GROUP, 2018-12-13)Embryonic mammary cells are a unique population comprised of undifferentiated, highly plastic progenitor cells that create normal mammary tissues. The mammary gland continues to develop after birth from descendants of ... -
SWATH mass spectrometry as a tool for quantitative profiling of the matrisome.
Krasny, L; Bland, P; Kogata, N; Wai, P; Howard, BA; et al. (ELSEVIER, 2018-03-01)Proteomic analysis of extracellular matrix (ECM) and ECM-associated proteins, collectively known as the matrisome, is a challenging task due to the inherent complexity and insolubility of these proteins. Here we present ... -
Thirteenth Annual ENBDC Workshop: Methods in Mammary Gland Biology and Breast Cancer.
Twigger, A-J; Sumbal, J; Bentires-Alj, M; Howard, BA (Springer Science and Business Media LLC, 2022-10-15)The thirteenth annual workshop of the European Network for Breast Development and Cancer (ENBDC) Laboratories Annual Workshop took place on the 28-30 April 2022 in Weggis, Switzerland and focused on methods in mammary gland ...