Browsing by author "Wohak, Laura"
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Carcinogenic polycyclic aromatic hydrocarbons induce CYP1A1 in human cells via a p53-dependent mechanism
Wohak, LE; Krais, AM; Kucab, JE; Stertmann, J; Øvrebø, S; et al. (Springer Science and Business Media LLC, 2016-02-01)The tumour suppressor gene TP53 is mutated in more than 50 % of human tumours, making it one of the most important cancer genes. We have investigated the role of TP53 in cytochrome P450 (CYP)-mediated metabolic activation ...