Browsing by author "Ford, Anthony"
Now showing items 1-16 of 16
-
A novel cryptic CBFB-MYH11 gene fusion present at birth leading to acute myeloid leukemia and allowing molecular monitoring for minimal residual disease
Poddighe, PJ; Veening, MA; Mansur, MB; Loonen, AH; Westers, TM; et al. (Elsevier BV, 2018-03-01) -
Can we prevent childhood Leukaemia?
Greaves, M; Cazzaniga, V; Ford, A (SPRINGERNATURE, 2021-05-01) -
Covert pre-leukaemic clones in healthy co-twins of patients with childhood acute lymphoblastic leukaemia.
Ford, AM; Colman, S; Greaves, M (SPRINGERNATURE, 2023-01-01) -
Cut-and-Run: A Distinct Mechanism by which V(D)J Recombination Causes Genome Instability.
Kirkham, CM; Scott, JNF; Wang, X; Smith, AL; Kupinski, AP; et al. (CELL PRESS, 2019-05-02)V(D)J recombination is essential to generate antigen receptor diversity but is also a potent cause of genome instability. Many chromosome alterations that result from aberrant V(D)J recombination involve breaks at single ... -
Development Refractoriness of MLL-Rearranged Human B Cell Acute Leukemias to Reprogramming into Pluripotency.
Muñoz-López, A; Romero-Moya, D; Prieto, C; Ramos-Mejía, V; Agraz-Doblas, A; et al. (CELL PRESS, 2016-10-11)Induced pluripotent stem cells (iPSCs) are a powerful tool for disease modeling. They are routinely generated from healthy donors and patients from multiple cell types at different developmental stages. However, reprogramming ... -
Expression of the fetal hematopoiesis regulator FEV indicates leukemias of prenatal origin.
Liu, T-H; Tang, Y-J; Huang, Y; Wang, L; Guo, X-L; et al. (Springer Science and Business Media LLC, 2017-05-01)The origin of cancers is associated with etiology as well as therapeutics. Several studies reveal that malignancies in children can originate in utero. However, a diagnostic approach to distinguish between cancers initiated ... -
Germline allelic expression of genes at 17q22 locus associates with risk of breast cancer.
Esteves, F; Xavier, JM; Ford, AM; Rocha, C; Pharoah, PDP; et al. (ELSEVIER SCI LTD, 2022-06-27)INTRODUCTION: Translation of genome-wide association study (GWAS) findings into preventive approaches is challenged by the identification of the causal risk variants and the understanding of the biological mechanisms by ... -
Orally bioavailable CDK9/2 inhibitor shows mechanism-based therapeutic potential in MYCN-driven neuroblastoma.
Poon, E; Liang, T; Jamin, Y; Walz, S; Kwok, C; et al. (AMER SOC CLINICAL INVESTIGATION INC, 2020-11-02)The undruggable nature of oncogenic Myc transcription factors poses a therapeutic challenge in neuroblastoma, a pediatric cancer in which MYCN amplification is strongly associated with unfavorable outcome. Here, we show ... -
Origins of STIL-TAL1 fusion genes in children who later developed paediatric T-cell acute lymphoblastic leukaemia: An investigation of neonatal blood spots.
Gustafsson, BM; Mattsson, K; Bogdanovic, G; Leijonhufvud, G; Honkaniemi, E; et al. (Wiley, 2018-11-01)SCL/TAL1 interrupting locus (STIL)-T-cell acute leukaemia (TAL1) fusion genes are present in approximately 11-27% of children with paediatric T-cell acute lymphoblastic leukaemia (T-ALL), but the developmental timing of ... -
Pro-inflammatory cytokines favor the emergence of ETV6-RUNX1-positive pre-leukemic cells in a model of mesenchymal niche.
Beneforti, L; Dander, E; Bresolin, S; Bueno, C; Acunzo, D; et al. (Wiley, 2020-01-01)ETV6-RUNX1 (E/R) fusion gene, arising in utero from translocation t(12;21)(p13:q22), is the most frequent alteration in childhood acute lymphoblastic leukemia (ALL). However, E/R is insufficient to cause overt leukemia ... -
Protracted dormancy of pre-leukemic stem cells.
Ford, AM; Mansur, MB; Furness, CL; van Delft, FW; Okamura, J; et al. (NATURE PUBLISHING GROUP, 2015-11-01)Cancer stem cells can escape therapeutic killing by adopting a quiescent or dormant state. The reversibility of this condition provides the potential for later recurrence or relapse, potentially many years later. We describe ... -
Targeting cyclooxygenase by indomethacin decelerates progression of acute lymphoblastic leukemia in a xenograft model.
Richartz, N; Duthil, E; Ford, A; Naderi, EH; Bhagwat, S; et al. (AMER SOC HEMATOLOGY, 2019-11-12)Acute lymphoblastic leukemia (ALL) develops in the bone marrow in the vicinity of stromal cells known to promote tumor development and treatment resistance. We previously showed that the cyclooxygenase (COX) inhibitor ... -
The genomic landscape of teenage and young adult T-cell acute lymphoblastic leukemia.
Mansur, MB; Furness, CL; Nakjang, S; Enshaei, A; Alpar, D; et al. (WILEY, 2021-07-01)BACKGROUND: Treatment on risk adapted intensive pediatric protocols has improved outcome for teenagers and young adults (TYA) with T-cell acute lymphoblastic leukemia (T-ALL). Understanding the biology of disease in this ... -
The Role of MicroRNA in Paediatric Acute Lymphoblastic Leukaemia: Challenges for Diagnosis and Therapy.
Grobbelaar, C; Ford, AM (Hindawi Limited, 2019-10-01)Acute lymphoblastic leukaemia (ALL) is the most common cancer of childhood. Although the overall survival of children with ALL is now more than 90%, leukaemia remains one of the leading causes of death from disease. In ... -
The role of RAS mutations in MLL-rearranged leukaemia: A path to intervention?
Mansur, MB; Ford, AM; Emerenciano, M (ELSEVIER, 2017-12-01)Childhood acute lymphoblastic leukaemia (ALL) with MLL rearrangement (MLL-r) is an aggressive disease still associated with a high mortality rate. Recent investigations have identified co-operating mutations in the RAS ... -
The subclonal complexity of STIL-TAL1+ T-cell acute lymphoblastic leukaemia.
Furness, CL; Mansur, MB; Weston, VJ; Ermini, L; van Delft, FW; et al. (NATURE PUBLISHING GROUP, 2018-09-01)Single-cell genetics were used to interrogate clonal complexity and the sequence of mutational events in STIL-TAL1+ T-ALL. Single-cell multicolour FISH was used to demonstrate that the earliest detectable leukaemia subclone ...