Now showing items 1-5 of 5

    • Cut-and-Run: A Distinct Mechanism by which V(D)J Recombination Causes Genome Instability. 

      Kirkham, CM; Scott, JNF; Wang, X; Smith, AL; Kupinski, AP; Ford, AM; Westhead, DR; Stockley, PG; Tuma, R; Boyes, J (2019-05-02)
      V(D)J recombination is essential to generate antigen receptor diversity but is also a potent cause of genome instability. Many chromosome alterations that result from aberrant V(D)J recombination involve breaks at single ...
    • Development Refractoriness of MLL-Rearranged Human B Cell Acute Leukemias to Reprogramming into Pluripotency. 

      Muñoz-López, A; Romero-Moya, D; Prieto, C; Ramos-Mejía, V; Agraz-Doblas, A; Varela, I; Buschbeck, M; Palau, A; Carvajal-Vergara, X; Giorgetti, A; Ford, A; Lako, M; Granada, I; Ruiz-Xivillé, N; Rodríguez-Perales, S; Torres-Ruíz, R; Stam, RW; Fuster, JL; Fraga, MF; Nakanishi, M; Cazzaniga, G; Bardini, M; Cobo, I; Bayon, GF; Fernandez, AF; Bueno, C; Menendez, P (2016-09-20)
      Induced pluripotent stem cells (iPSCs) are a powerful tool for disease modeling. They are routinely generated from healthy donors and patients from multiple cell types at different developmental stages. However, reprogramming ...
    • MLL translocations with concurrent 3 ' deletions: Interpretation of FISH results 

      Ford, T (2004-11)
      MLL translocations with concurrent 3 ' deletions: Interpretation of FISH results Rearrangements involving the MLL gene at 11q23 occur in a clinically relevant subgroup of patients with acute lymphoblastic leukemia (ALL) ...
    • The role of RAS mutations in MLL-rearranged leukaemia: A path to intervention? 

      Mansur, MB; Ford, AM; Emerenciano, M (2017-12)
      Childhood acute lymphoblastic leukaemia (ALL) with MLL rearrangement (MLL-r) is an aggressive disease still associated with a high mortality rate. Recent investigations have identified co-operating mutations in the RAS ...
    • The subclonal complexity of STIL-TAL1+ T-cell acute lymphoblastic leukaemia. 

      Furness, CL; Mansur, MB; Weston, VJ; Ermini, L; van Delft, FW; Jenkinson, S; Gale, R; Harrison, CJ; Pombo-de-Oliveira, MS; Sanchez-Martin, M; Ferrando, AA; Kearns, P; Titley, I; Ford, AM; Potter, NE; Greaves, M (2018-09)
      Single-cell genetics were used to interrogate clonal complexity and the sequence of mutational events in STIL-TAL1+ T-ALL. Single-cell multicolour FISH was used to demonstrate that the earliest detectable leukaemia subclone ...