Browsing by author "Swerdlow, Anthony"
Now showing items 21-40 of 108
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Breast cancer risk in relation to history of preeclampsia and hyperemesis gravidarum: Prospective analysis in the Generations Study.
Wright, LB; Schoemaker, MJ; Jones, ME; Ashworth, A; Swerdlow, AJ (WILEY, 2018-08-15)Preeclampsia and hyperemesis gravidarum are pregnancy complications associated with altered sex hormone levels. Previous studies suggest preeclampsia may be associated with a decreased risk of subsequent breast cancer and ... -
Breast cancer risk variants at 6q25 display different phenotype associations and regulate ESR1, RMND1 and CCDC170.
Dunning, AM; Michailidou, K; Kuchenbaecker, KB; Thompson, D; French, JD; et al. (NATURE PUBLISHING GROUP, 2016-04-01)We analyzed 3,872 common genetic variants across the ESR1 locus (encoding estrogen receptor α) in 118,816 subjects from three international consortia. We found evidence for at least five independent causal variants, each ... -
Cancer Risks in Patients Treated With Growth Hormone in Childhood: The SAGhE European Cohort Study.
Swerdlow, AJ; Cooke, R; Beckers, D; Borgström, B; Butler, G; et al. (ENDOCRINE SOC, 2017-05-01)CONTEXT: Growth hormone (GH) is prescribed for an increasing range of indications, but there has been concern that it might raise cancer risk. Published data are limited. OBJECTIVE: To examine cancer risks in relation to ... -
Cell-type-specific eQTL of primary melanocytes facilitates identification of melanoma susceptibility genes.
Zhang, T; Choi, J; Kovacs, MA; Shi, J; Xu, M; et al. (COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT, 2018-11-01)Most expression quantitative trait locus (eQTL) studies to date have been performed in heterogeneous tissues as opposed to specific cell types. To better understand the cell-type-specific regulatory landscape of human ... -
Childhood body size and pubertal timing in relation to adult mammographic density phenotype.
Schoemaker, MJ; Jones, ME; Allen, S; Hoare, J; Ashworth, A; et al. (BMC, 2017-02-07)BACKGROUND: An earlier age at onset of breast development and longer time between pubertal stages has been implicated in breast cancer risk. It is not clear whether associations of breast cancer risk with puberty or ... -
Circulating anti-Müllerian hormone and breast cancer risk: A study in ten prospective cohorts.
Ge, W; Clendenen, TV; Afanasyeva, Y; Koenig, KL; Agnoli, C; et al. (WILEY, 2018-06-01)A strong positive association has been observed between circulating anti-Müllerian hormone (AMH), a biomarker of ovarian reserve, and breast cancer risk in three prospective studies. Confirming this association is important ... -
Circulating Vitamin D and Colorectal Cancer Risk: An International Pooling Project of 17 Cohorts.
McCullough, ML; Zoltick, ES; Weinstein, SJ; Fedirko, V; Wang, M; et al. (OXFORD UNIV PRESS INC, 2019-02-01)BACKGROUND: Experimental and epidemiological studies suggest a protective role for vitamin D in colorectal carcinogenesis, but evidence is inconclusive. Circulating 25-hydroxyvitamin D (25(OH)D) concentrations that minimize ... -
Combined Associations of a Polygenic Risk Score and Classical Risk Factors With Breast Cancer Risk.
Kapoor, PM; Mavaddat, N; Choudhury, PP; Wilcox, AN; Lindström, S; et al. (OXFORD UNIV PRESS INC, 2021-03-01)We evaluated the joint associations between a new 313-variant PRS (PRS313) and questionnaire-based breast cancer risk factors for women of European ancestry, using 72 284 cases and 80 354 controls from the Breast Cancer ... -
Combined effects of endogenous sex hormone levels and mammographic density on postmenopausal breast cancer risk: results from the Breakthrough Generations Study.
Schoemaker, MJ; Folkerd, EJ; Jones, ME; Rae, M; Allen, S; et al. (NATURE PUBLISHING GROUP, 2014-04-02)BACKGROUND: Mammographic density and sex hormone levels are strong risk factors for breast cancer, but it is unclear whether they represent the same aetiological entity or are independent risk factors. METHODS: Within the ... -
Common Susceptibility Loci for Male Breast Cancer.
Maguire, S; Perraki, E; Tomczyk, K; Jones, ME; Fletcher, O; et al. (OXFORD UNIV PRESS INC, 2021-04-06)BACKGROUND: The etiology of male breast cancer (MBC) is poorly understood. In particular, the extent to which the genetic basis of MBC differs from female breast cancer (FBC) is unknown. A previous genome-wide association ... -
Comparative Validation of Breast Cancer Risk Prediction Models and Projections for Future Risk Stratification.
Pal Choudhury, P; Wilcox, AN; Brook, MN; Zhang, Y; Ahearn, T; et al. (OXFORD UNIV PRESS INC, 2020-03-01)BACKGROUND: External validation of risk models is critical for risk-stratified breast cancer prevention. We used the Individualized Coherent Absolute Risk Estimation (iCARE) as a flexible tool for risk model development ... -
Cross-Cancer Genome-Wide Association Study of Endometrial Cancer and Epithelial Ovarian Cancer Identifies Genetic Risk Regions Associated with Risk of Both Cancers.
Glubb, DM; Thompson, DJ; Aben, KKH; Alsulimani, A; Amant, F; et al. (AMER ASSOC CANCER RESEARCH, 2021-01-01)BACKGROUND: Accumulating evidence suggests a relationship between endometrial cancer and ovarian cancer. Independent genome-wide association studies (GWAS) for endometrial cancer and ovarian cancer have identified 16 and ... -
Domestic light at night and breast cancer risk: a prospective analysis of 105 000 UK women in the Generations Study.
Johns, LE; Jones, ME; Schoemaker, MJ; McFadden, E; Ashworth, A; et al. (NATURE PUBLISHING GROUP, 2018-02-20)BACKGROUND: Circadian disruption caused by exposure to light at night (LAN) has been proposed as a risk factor for breast cancer and a reason for secular increases in incidence. Studies to date have largely been ecological ... -
E-cadherin breast tumor expression, risk factors and survival: Pooled analysis of 5,933 cases from 12 studies in the Breast Cancer Association Consortium.
Horne, HN; Oh, H; Sherman, ME; Palakal, M; Hewitt, SM; et al. (NATURE PORTFOLIO, 2018-04-26)E-cadherin (CDH1) is a putative tumor suppressor gene implicated in breast carcinogenesis. Yet, whether risk factors or survival differ by E-cadherin tumor expression is unclear. We evaluated E-cadherin tumor immunohistochemistry ... -
Effect of population breast screening on breast cancer mortality up to 2005 in England and Wales: an individual-level cohort study.
Johns, LE; Coleman, DA; Swerdlow, AJ; Moss, SM (SPRINGERNATURE, 2017-01-17)BACKGROUND: Population breast screening has been implemented in the UK for over 25 years, but the size of benefit attributable to such programmes remains controversial. We have conducted the first individual-based cohort ... -
Etiology of hormone receptor positive breast cancer differs by levels of histologic grade and proliferation.
Abubakar, M; Chang-Claude, J; Ali, HR; Chatterjee, N; Coulson, P; et al. (WILEY, 2018-08-15)Limited epidemiological evidence suggests that the etiology of hormone receptor positive (HR+) breast cancer may differ by levels of histologic grade and proliferation. We pooled risk factor and pathology data on 5,905 HR+ ... -
Evidence that the 5p12 Variant rs10941679 Confers Susceptibility to Estrogen-Receptor-Positive Breast Cancer through FGF10 and MRPS30 Regulation.
Ghoussaini, M; French, JD; Michailidou, K; Nord, S; Beesley, J; et al. (CELL PRESS, 2016-10-06)Genome-wide association studies (GWASs) have revealed increased breast cancer risk associated with multiple genetic variants at 5p12. Here, we report the fine mapping of this locus using data from 104,660 subjects from 50 ... -
Exposure to loud noise and risk of vestibular schwannoma: results from the INTERPHONE international case‒control study.
Deltour, I; Schlehofer, B; Massardier-Pilonchéry, A; Schlaefer, K; Armstrong, B; et al. (SCANDINAVIAN JOURNAL WORK ENVIRONMENT & HEALTH, 2018-11-05)Objective Studies of loud noise exposure and vestibular schwannomas (VS) have shown conflicting results. The population-based INTERPHONE case‒control study was conducted in 13 countries during 2000-2004. In this paper, we ... -
Family history and risk of breast cancer: an analysis accounting for family structure.
Brewer, HR; Jones, ME; Schoemaker, MJ; Ashworth, A; Swerdlow, AJ (SPRINGER, 2017-08-01)PURPOSE: Family history is an important risk factor for breast cancer incidence, but the parameters conventionally used to categorize it are based solely on numbers and/or ages of breast cancer cases in the family and take ... -
Fine scale mapping of the 17q22 breast cancer locus using dense SNPs, genotyped within the Collaborative Oncological Gene-Environment Study (COGs).
Darabi, H; Beesley, J; Droit, A; Kar, S; Nord, S; et al. (NATURE PORTFOLIO, 2016-09-07)Genome-wide association studies have found SNPs at 17q22 to be associated with breast cancer risk. To identify potential causal variants related to breast cancer risk, we performed a high resolution fine-mapping analysis ...