Browsing by author "Wang, Hannah"
Chemical approaches to targeted protein degradation through modulation of the ubiquitin-proteasome pathway. Collins, I; Wang, H; Caldwell, JJ; Chopra, R (2017-03-15)Manipulation of the ubiquitin-proteasome system to achieve targeted degradation of proteins within cells using chemical tools and drugs has the potential to transform pharmacological and therapeutic approaches in cancer ...
Mutations in CRBN and other cereblon pathway genes are infrequently associated with acquired resistance to immunomodulatory drugs. Jones, JR; Barber, A; Le Bihan, Y-V; Weinhold, N; Ashby, C; Walker, BA; Wardell, CP; Wang, H; Kaiser, MF; Jackson, GH; Davies, FE; Chopra, R; Morgan, GJ; Pawlyn, C
Second-Generation HSP90 Inhibitor Onalespib Blocks mRNA Splicing of Androgen Receptor Variant 7 in Prostate Cancer Cells. Ferraldeschi, R; Welti, J; Powers, MV; Yuan, W; Smyth, T; Seed, G; Riisnaes, R; Hedayat, S; Wang, H; Crespo, M; Nava Rodrigues, D; Figueiredo, I; Miranda, S; Carreira, S; Lyons, JF; Sharp, S; Plymate, SR; Attard, G; Wallis, N; Workman, P; de Bono, JS (2016-05)Resistance to available hormone therapies in prostate cancer has been associated with alternative splicing of androgen receptor (AR) and specifically, the expression of truncated and constitutively active AR variant 7 ...