Browsing by author "Kinnersley, Benjamin"
Now showing items 21-34 of 34
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Mendelian randomisation study of the relationship between vitamin D and risk of glioma.
Takahashi, H; Cornish, AJ; Sud, A; Law, PJ; Kinnersley, B; et al. (NATURE PUBLISHING GROUP, 2018-02-05)To examine for a causal relationship between vitamin D and glioma risk we performed an analysis of genetic variants associated with serum 25-hydroxyvitamin D (25(OH)D) levels using Mendelian randomisation (MR), an approach ... -
Partitioned glioma heritability shows subtype-specific enrichment in immune cells.
Ostrom, QT; Edelson, J; Byun, J; Han, Y; Kinnersley, B; et al. (OXFORD UNIV PRESS INC, 2021-08-02)BACKGROUND: Epidemiological studies of adult glioma have identified genetic syndromes and 25 heritable risk loci that modify individual risk for glioma, as well increased risk in association with exposure to ionizing ... -
Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9.
Schmidt, AF; Holmes, MV; Preiss, D; Swerdlow, DI; Denaxas, S; et al. (BMC, 2019-10-29)BACKGROUND: We characterised the phenotypic consequence of genetic variation at the PCSK9 locus and compared findings with recent trials of pharmacological inhibitors of PCSK9. METHODS: Published and individual participant ... -
Rare disruptive mutations and their contribution to the heritable risk of colorectal cancer.
Chubb, D; Broderick, P; Dobbins, SE; Frampton, M; Kinnersley, B; et al. (NATURE PUBLISHING GROUP, 2016-06-22)Colorectal cancer (CRC) displays a complex pattern of inheritance. It is postulated that much of the missing heritability of CRC is enshrined in high-impact rare alleles, which are mechanistically and clinically important. ... -
Rare variants of large effect in BRCA2 and CHEK2 affect risk of lung cancer.
Wang, Y; McKay, JD; Rafnar, T; Wang, Z; Timofeeva, MN; et al. (NATURE PUBLISHING GROUP, 2014-09-11)We conducted imputation to the 1000 Genomes Project of four genome-wide association studies of lung cancer in populations of European ancestry (11,348 cases and 15,861 controls) and genotyped an additional 10,246 cases and ... -
Relationship between genetically determined telomere length and glioma risk.
Saunders, CN; Kinnersley, B; Culliford, R; Cornish, AJ; Law, PJ; et al. (OXFORD UNIV PRESS INC, 2022-02-01)BACKGROUND: Telomere maintenance is increasingly recognized as being fundamental to glioma oncogenesis with longer leukocyte telomere length (LTL) reported to increase risk of glioma. To gain further insight into the ... -
Search for multiple myeloma risk factors using Mendelian randomization.
Went, M; Cornish, AJ; Law, PJ; Kinnersley, B; van Duin, M; et al. (AMER SOC HEMATOLOGY, 2020-05-26)The etiology of multiple myeloma (MM) is poorly understood. Summary data from genome-wide association studies (GWASs) of multiple phenotypes can be exploited in a Mendelian randomization (MR) phenome-wide association study ... -
Searching for causal relationships of glioma: a phenome-wide Mendelian randomisation study.
Saunders, CN; Cornish, AJ; Kinnersley, B; Law, PJ; Houlston, RS; et al. (SPRINGERNATURE, 2021-01-19)BACKGROUND: The aetiology of glioma is poorly understood. Summary data from genome-wide association studies (GWAS) can be used in a Mendelian randomisation (MR) phenome-wide association study (PheWAS) to search for glioma ... -
Sex-specific glioma genome-wide association study identifies new risk locus at 3p21.31 in females, and finds sex-differences in risk at 8q24.21.
Ostrom, QT; Kinnersley, B; Wrensch, MR; Eckel-Passow, JE; Armstrong, G; et al. (NATURE PORTFOLIO, 2018-05-09)Incidence of glioma is approximately 50% higher in males. Previous analyses have examined exposures related to sex hormones in women as potential protective factors for these tumors, with inconsistent results. Previous ... -
Transcriptome-Wide Association Study Identifies New Candidate Susceptibility Genes for Glioma.
Atkins, I; Kinnersley, B; Ostrom, QT; Labreche, K; Il'yasova, D; et al. (AMER ASSOC CANCER RESEARCH, 2019-04-15)Genome-wide association studies (GWAS) have so far identified 25 loci associated with glioma risk, with most showing specificity for either glioblastoma (GBM) or non-GBM tumors. The majority of these GWAS susceptibility ... -
Transcriptome-wide association study of multiple myeloma identifies candidate susceptibility genes.
Went, M; Kinnersley, B; Sud, A; Johnson, DC; Weinhold, N; et al. (BMC, 2019-08-20)BACKGROUND: While genome-wide association studies (GWAS) of multiple myeloma (MM) have identified variants at 23 regions influencing risk, the genes underlying these associations are largely unknown. To identify candidate ... -
Undefined familial colorectal cancer and the role of pleiotropism in cancer susceptibility genes.
Dobbins, SE; Broderick, P; Chubb, D; Kinnersley, B; Sherborne, AL; et al. (SPRINGER, 2016-06-29)Although family history is a major risk factor for colorectal cancer (CRC) a genetic diagnosis cannot be obtained in over 50 % of familial cases when screened for known CRC cancer susceptibility genes. The genetics of ... -
Validation of Recently Proposed Colorectal Cancer Susceptibility Gene Variants in an Analysis of Families and Patients-a Systematic Review.
Broderick, P; Dobbins, SE; Chubb, D; Kinnersley, B; Dunlop, MG; et al. (W B SAUNDERS CO-ELSEVIER INC, 2017-01-01)High-throughput sequencing analysis has accelerated searches for genes associated with risk for colorectal cancer (CRC); germline mutations in NTHL1, RPS20, FANCM, FAN1, TP53, BUB1, BUB3, LRP6, and PTPN12 have been recently ... -
Whole-genome sequencing of chronic lymphocytic leukemia identifies subgroups with distinct biological and clinical features.
Robbe, P; Ridout, KE; Vavoulis, DV; Dréau, H; Kinnersley, B; et al. (NATURE PORTFOLIO, 2022-11-01)The value of genome-wide over targeted driver analyses for predicting clinical outcomes of cancer patients is debated. Here, we report the whole-genome sequencing of 485 chronic lymphocytic leukemia patients enrolled in ...