Now showing items 1-13 of 13

    • Genome-wide association analysis identifies a meningioma risk locus at 11p15.5. 

      Claus, EB; Cornish, AJ; Broderick, P; Schildkraut, JM; Dobbins, SE; Holroyd, A; Calvocoressi, L; Lu, L; Hansen, HM; Smirnov, I; Walsh, KM; Schramm, J; Hoffmann, P; Nöthen, MM; Jöckel, K-H; Swerdlow, A; Larsen, SB; Johansen, C; Simon, M; Bondy, M; Wrensch, M; Houlston, RS; Wiemels, JL (2018-10)
      Background:Meningiomas are adult brain tumors originating in the meningeal coverings of the brain and spinal cord, with significant heritable basis. Genome-wide association studies (GWAS) have previously identified only a ...
    • Identification of recurrent noncoding mutations in B-cell lymphoma using capture Hi-C. 

      Cornish, AJ; Hoang, PH; Dobbins, SE; Law, PJ; Chubb, D; Orlando, G; Houlston, RS (2019-01)
      The identification of driver mutations is fundamental to understanding oncogenesis. Although genes frequently mutated in B-cell lymphoma have been identified, the search for driver mutations has largely focused on the ...
    • Impact of atopy on risk of glioma: a Mendelian randomisation study. 

      Disney-Hogg, L; Cornish, AJ; Sud, A; Law, PJ; Kinnersley, B; Jacobs, DI; Ostrom, QT; Labreche, K; Eckel-Passow, JE; Armstrong, GN; Claus, EB; Il'yasova, D; Schildkraut, J; Barnholtz-Sloan, JS; Olson, SH; Bernstein, JL; Lai, RK; Schoemaker, MJ; Simon, M; Hoffmann, P; Nöthen, MM; Jöckel, K-H; Chanock, S; Rajaraman, P; Johansen, C; Jenkins, RB; Melin, BS; Wrensch, MR; Sanson, M; Bondy, ML; Houlston, RS (2018-03-15)
      An inverse relationship between allergies with glioma risk has been reported in several but not all epidemiological observational studies. We performed an analysis of genetic variants associated with atopy to assess the ...
    • Impact of mitochondrial DNA mutations in multiple myeloma. 

      Hoang, PH; Cornish, AJ; Chubb, D; Jackson, G; Kaiser, M; Houlston, RS (2020-05)
    • Influence of obesity-related risk factors in the aetiology of glioma. 

      Disney-Hogg, L; Sud, A; Law, PJ; Cornish, AJ; Kinnersley, B; Ostrom, QT; Labreche, K; Eckel-Passow, JE; Armstrong, GN; Claus, EB; Il'yasova, D; Schildkraut, J; Barnholtz-Sloan, JS; Olson, SH; Bernstein, JL; Lai, RK; Swerdlow, AJ; Simon, M; Hoffmann, P; Nöthen, MM; Jöckel, K-H; Chanock, S; Rajaraman, P; Johansen, C; Jenkins, RB; Melin, BS; Wrensch, MR; Sanson, M; Bondy, ML; Houlston, RS (2018-04)
      BACKGROUND:Obesity and related factors have been implicated as possible aetiological factors for the development of glioma in epidemiological observation studies. We used genetic markers in a Mendelian randomisation framework ...
    • Mendelian randomisation study of the relationship between vitamin D and risk of glioma. 

      Takahashi, H; Cornish, AJ; Sud, A; Law, PJ; Kinnersley, B; Ostrom, QT; Labreche, K; Eckel-Passow, JE; Armstrong, GN; Claus, EB; Il'yasova, D; Schildkraut, J; Barnholtz-Sloan, JS; Olson, SH; Bernstein, JL; Lai, RK; Schoemaker, MJ; Simon, M; Hoffmann, P; Nöthen, MM; Jöckel, K-H; Chanock, S; Rajaraman, P; Johansen, C; Jenkins, RB; Melin, BS; Wrensch, MR; Sanson, M; Bondy, ML; Turnbull, C; Houlston, RS (2018-02-05)
      To examine for a causal relationship between vitamin D and glioma risk we performed an analysis of genetic variants associated with serum 25-hydroxyvitamin D (25(OH)D) levels using Mendelian randomisation (MR), an approach ...
    • Mendelian randomisation: A powerful and inexpensive method for identifying and excluding non-genetic risk factors for colorectal cancer. 

      Cornish, AJ; Tomlinson, IPM; Houlston, RS (2019-10)
      Colorectal cancer (CRC) is the third most common cancer in economically developed countries and a major cause of cancer-related mortality. The importance of lifestyle and diet as major determinants of CRC risk is suggested ...
    • Mendelian randomization provides support for obesity as a risk factor for meningioma. 

      Takahashi, H; Cornish, AJ; Sud, A; Law, PJ; Disney-Hogg, L; Calvocoressi, L; Lu, L; Hansen, HM; Smirnov, I; Walsh, KM; Schramm, J; Hoffmann, P; Nöthen, MM; Jöckel, K-H; Schildkraut, JM; Simon, M; Bondy, M; Wrensch, M; Wiemels, JL; Claus, EB; Turnbull, C; Houlston, RS (2019-01-22)
      Little is known about the causes of meningioma. Obesity and obesity-related traits have been reported in several epidemiological observational studies to be risk factors for meningioma. We performed an analysis of genetic ...
    • Modifiable pathways for colorectal cancer: a mendelian randomisation analysis. 

      Cornish, AJ; Law, PJ; Timofeeva, M; Palin, K; Farrington, SM; Palles, C; Jenkins, MA; Casey, G; Brenner, H; Chang-Claude, J; Hoffmeister, M; Kirac, I; Maughan, T; Brezina, S; Gsur, A; Cheadle, JP; Aaltonen, LA; Tomlinson, I; Dunlop, MG; Houlston, RS (2020-01)
      BACKGROUND:Epidemiological studies have linked lifestyle, cardiometabolic, reproductive, developmental, and inflammatory factors to the risk of colorectal cancer. However, which specific factors affect risk and the strength ...
    • Mutational processes contributing to the development of multiple myeloma. 

      Hoang, PH; Cornish, AJ; Dobbins, SE; Kaiser, M; Houlston, RS (2019-08-06)
      To gain insight into multiple myeloma (MM) tumorigenesis, we analyzed the mutational signatures in 874 whole-exome and 850 whole-genome data from the CoMMpass Study. We identified that coding and non-coding regions are ...
    • Promoter capture Hi-C-based identification of recurrent noncoding mutations in colorectal cancer. 

      Orlando, G; Law, PJ; Cornish, AJ; Dobbins, SE; Chubb, D; Broderick, P; Litchfield, K; Hariri, F; Pastinen, T; Osborne, CS; Taipale, J; Houlston, RS (2018-10)
      Efforts are being directed to systematically analyze the non-coding regions of the genome for cancer-driving mutations1-6. cis-regulatory elements (CREs) represent a highly enriched subset of the non-coding regions of the ...
    • Search for multiple myeloma risk factors using Mendelian randomization. 

      Went, M; Cornish, AJ; Law, PJ; Kinnersley, B; van Duin, M; Weinhold, N; Försti, A; Hansson, M; Sonneveld, P; Goldschmidt, H; Morgan, GJ; Hemminki, K; Nilsson, B; Kaiser, M; Houlston, RS (2020-05)
      The etiology of multiple myeloma (MM) is poorly understood. Summary data from genome-wide association studies (GWASs) of multiple phenotypes can be exploited in a Mendelian randomization (MR) phenome-wide association study ...
    • Whole-genome sequencing of multiple myeloma reveals oncogenic pathways are targeted somatically through multiple mechanisms. 

      Hoang, PH; Dobbins, SE; Cornish, AJ; Chubb, D; Law, PJ; Kaiser, M; Houlston, RS (2018-11)
      Multiple myeloma (MM) is a biologically heterogeneous malignancy, however, the mechanisms underlying this complexity are incompletely understood. We report an analysis of the whole-genome sequencing of 765 MM patients from ...