Browsing by author "Desouza, Nandita"
Now showing items 21-40 of 65
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Evaluation of a multi-atlas CT synthesis approach for MRI-only radiotherapy treatment planning.
Guerreiro, F; Burgos, N; Dunlop, A; Wong, K; Petkar, I; et al. (ELSEVIER SCI LTD, 2017-03-01)BACKGROUND AND PURPOSE: Computed tomography (CT) imaging is the current gold standard for radiotherapy treatment planning (RTP). The establishment of a magnetic resonance imaging (MRI) only RTP workflow requires the ... -
Evaluation of diffusion models in breast cancer.
Panek, R; Borri, M; Orton, M; O'Flynn, E; Morgan, V; et al. (WILEY, 2015-08-01)PURPOSE: The purpose of this study is to investigate whether the microvascular pseudodiffusion effects resulting with non-monoexponential behavior are present in breast cancer, taking into account tumor spatial heterogeneity. ... -
Evaluation of diffusion-weighted MRI and (18F) fluorothymidine-PET biomarkers for early response assessment in patients with operable non-small cell lung cancer treated with neoadjuvant chemotherapy.
Carlin, D; Weller, A; Kramer, G; Liu, Y; Waterton, JC; et al. (Oxford University Press (OUP), 2019-01-01)OBJECTIVE: To correlate changes in the apparent diffusion coefficient (ADC) from diffusion-weighted (DW)-MRI and standardised uptake value (SUV) from fluorothymidine (18FLT)-PET/CT with histopathological estimates of ... -
Evaluation of Quality of Life Outcomes Following Palliative Treatment of Bone Metastases with Magnetic Resonance-guided High Intensity Focused Ultrasound: An International Multicentre Study.
Harding, D; Giles, SL; Brown, MRD; Ter Haar, GR; van den Bosch, M; et al. (ELSEVIER SCIENCE LONDON, 2018-04-01)AIMS: To determine quality of life (QoL) outcomes after palliation of pain from bone metastases using magnetic resonance-guided high intensity focused ultrasound (MR-guided HIFU), measured using the European Organization ... -
Extracranial Soft-Tissue Tumors: Repeatability of Apparent Diffusion Coefficient Estimates from Diffusion-weighted MR Imaging.
Winfield, JM; Tunariu, N; Rata, M; Miyazaki, K; Jerome, NP; et al. (RADIOLOGICAL SOC NORTH AMERICA, 2017-07-01)Purpose To assess the repeatability of apparent diffusion coefficient (ADC) estimates in extracranial soft-tissue diffusion-weighted magnetic resonance imaging across a wide range of imaging protocols and patient populations. ... -
Feasibility of palliating recurrent gynecological tumors with MRGHIFU: comparison of symptom, quality-of-life, and imaging response in intra and extra-pelvic disease.
Imseeh, G; Giles, SL; Taylor, A; Brown, MRD; Rivens, I; et al. (TAYLOR & FRANCIS LTD, 2021-01-01)OBJECTIVE: To document longitudinal symptom, quality-of-life and imaging response in patients with recurrent gynecological tumors treated with magnetic resonance guided high intensity focused ultrasound (MRgHIFU), and ... -
Imaging biomarker roadmap for cancer studies.
O'Connor, JPB; Aboagye, EO; Adams, JE; Aerts, HJWL; Barrington, SF; et al. (NATURE PORTFOLIO, 2017-03-01)Imaging biomarkers (IBs) are integral to the routine management of patients with cancer. IBs used daily in oncology include clinical TNM stage, objective response and left ventricular ejection fraction. Other CT, MRI, PET ... -
Implementing diffusion-weighted MRI for body imaging in prospective multicentre trials: current considerations and future perspectives.
deSouza, NM; Winfield, JM; Waterton, JC; Weller, A; Papoutsaki, M-V; et al. (SPRINGER, 2018-03-01)UNLABELLED: For body imaging, diffusion-weighted MRI may be used for tumour detection, staging, prognostic information, assessing response and follow-up. Disease detection and staging involve qualitative, subjective ... -
Incorporating radiomics into clinical trials: expert consensus endorsed by the European Society of Radiology on considerations for data-driven compared to biologically driven quantitative biomarkers.
Fournier, L; Costaridou, L; Bidaut, L; Michoux, N; Lecouvet, FE; et al. (SPRINGER, 2021-01-25)Existing quantitative imaging biomarkers (QIBs) are associated with known biological tissue characteristics and follow a well-understood path of technical, biological and clinical validation before incorporation into ... -
Initial experience of the BREAST-Q breast-conserving therapy module.
O'Connell, RL; DiMicco, R; Khabra, K; O'Flynn, EA; deSouza, N; et al. (SPRINGER, 2016-11-01)PURPOSE: The most recently developed module of the BREAST-Q, a validated patient outcome measure, is for patients who have undergone breast-conserving therapy (BCT) for cancer. This aim of this study was to assess patient ... -
Iterative framework for the joint segmentation and CT synthesis of MR images: application to MRI-only radiotherapy treatment planning.
Burgos, N; Guerreiro, F; McClelland, J; Presles, B; Modat, M; et al. (IOP PUBLISHING LTD, 2017-06-07)To tackle the problem of magnetic resonance imaging (MRI)-only radiotherapy treatment planning (RTP), we propose a multi-atlas information propagation scheme that jointly segments organs and generates pseudo x-ray computed ... -
Lab-on-chip assay of tumour markers and human papilloma virus for cervical cancer detection at the point-of-care.
Wormald, BW; Moser, N; deSouza, NM; Mantikas, K-T; Malpartida-Cardenas, K; et al. (NATURE PORTFOLIO, 2022-05-24)Cervical cancer affects over half a million people worldwide each year, the majority of whom are in resource-limited settings where cytology screening is not available. As persistent human papilloma virus (HPV) infections ... -
Loop-Mediated Isothermal Amplification Assay for Detecting Tumor Markers and Human Papillomavirus: Accuracy and Supplemental Diagnostic Value to Endovaginal MRI in Cervical Cancer.
Wormald, B; Rodriguez-Manzano, J; Moser, N; Pennisi, I; Ind, TEJ; et al. (FRONTIERS MEDIA SA, 2021-11-01)OBJECTIVE: To establish the sensitivity and specificity of a human papillomavirus (HPV) and tumor marker DNA/mRNA assay for detecting cervical cancer that is transferrable to a Lab-on-a-chip platform and determine its ... -
Mechanism and non-mechanism based imaging biomarkers for assessing biological response to treatment in non-small cell lung cancer.
Weller, A; O'Brien, MER; Ahmed, M; Popat, S; Bhosle, J; et al. (ELSEVIER SCI LTD, 2016-05-01)Therapeutic options in locally advanced non-small cell lung cancer (NSCLC) have expanded in the past decade to include a palate of targeted interventions such as high dose targeted thermal ablations, radiotherapy and growing ... -
Monitoring Tumor Volume in Patients With Prostate Cancer Undergoing Active Surveillance: Is MRI Apparent Diffusion Coefficient Indicative of Tumor Growth?
Morgan, VA; Parker, C; MacDonald, A; Thomas, K; deSouza, NM (AMER ROENTGEN RAY SOC, 2017-09-01)OBJECTIVE: The purpose of this study was to measure longitudinal change in tumor volume of the dominant intraprostatic lesion and determine whether baseline apparent diffusion coefficient (ADC) and change in ADC are ... -
MR guided high intensity focused ultrasound (MRgHIFU) for treating recurrent gynaecological tumours: a pilot feasibility study.
Giles, SL; Imseeh, G; Rivens, I; Ter Haar, GR; Taylor, A; et al. (BRITISH INST RADIOLOGY, 2019-05-16)OBJECTIVE: To assess the feasibility of targeting recurrent gynaecological tumours with MR guided high intensity focused ultrasound (MRgHIFU). METHODS: 20 patients with recurrent gynaecological tumours were prospectively ... -
MRI Apparent Diffusion Coefficient (ADC) as a Biomarker of Tumour Response: Imaging-Pathology Correlation in Patients with Hepatic Metastases from Colorectal Cancer (EORTC 1423).
Jackson, A; Pathak, R; deSouza, NM; Liu, Y; Jacobs, BKM; et al. (MDPI, 2023-07-12)Background: Tumour apparent diffusion coefficient (ADC) from diffusion-weighted magnetic resonance imaging (MRI) is a putative pharmacodynamic/response biomarker but the relationship between drug-induced effects on the ADC ... -
MRI measurement of residual cervical length after radical trachelectomy for cervical cancer and the risk of adverse pregnancy outcomes: a blinded imaging analysis.
Alvarez, RM; Biliatis, I; Rockall, A; Papadakou, E; Sohaib, SA; et al. (WILEY, 2018-12-01)OBJECTIVE: To determine the association between the residual cervix measured on postoperative MRI after radical vaginal trachelectomy (RVT) and adverse obstetrical outcomes. DESIGN: Observational study. SETTING: Referral ... -
On the Comparative Suitability of Strain Relaxation and Stress Relaxation Compression for Ultrasound Poroelastic Tissue Characterization
Theodorou, M; Fromageau, J; DeSouza, NM; Bamber, JC (FRONTIERS MEDIA SA, 2021-05-10)<jats:p>Poroelastic tissue strain imaging measures the time-varying and spatially varying deformation of a soft-tissue matrix during compression as the tissue fluid flows out of the compartmental boundaries. With the help ... -
Phase I clinical trial repurposing all-trans retinoic acid as a stromal targeting agent for pancreatic cancer.
Kocher, HM; Basu, B; Froeling, FEM; Sarker, D; Slater, S; et al. (NATURE RESEARCH, 2020-09-24)Pre-clinical models have shown that targeting pancreatic stellate cells with all-trans-retinoic-acid (ATRA) reprograms pancreatic stroma to suppress pancreatic ductal adenocarcinoma (PDAC) growth. Here, in a phase Ib, dose ...