Now showing items 1-5 of 5

    • Do all patients with bilateral testis cancer have a hereditary predisposition? 

      Harland, SJ; Rapley, EA; Nicholson, PW (Wiley/Blackwell (10.1111), 2007-08-09)
      Summary An international study has demonstrated that patients with bilateral testicular cancer are significantly more likely to have brothers with testis cancer than those with unilateral disease. This, together with other ...
    • Genetic predisposition to testicular germ-cell tumours. 

      Rapley, L (2004-06)
      Genetic predisposition to testicular germ-cell tumours Testicular germ-cell tumours (TGCT) are the most common neoplasm in young men. Various studies have suggested the existence of an inherited predisposition to development ...
    • Localisation of susceptibility genes for familial testicular germ cell tumour 

      Rapley, L; Stratton, M (2003-01)
      Localisation of susceptibility genes for familial testicular germ cell tumour. Approximately 1700 men in the United Kingdom develop testicular germ cell tumours (TGCT) per year. Among the known risk factors a family history ...
    • Predisposition alleles for testicular germ cell tumour 

      Rapley, EA; Nathanson, KL (CURRENT BIOLOGY LTD, 2010-06)
      For some time, it has been known that there is a substantial genetic component to testicular germ cell tumour susceptibility, supported by several pieces of evidence, including the significantly increased familial risk and ...
    • Susceptibility alleles for testicular germ cell tumour: a review 

      Rapley, L (2007-08)
      Family history is among the strongest and most consistent of the risk factors for testicular germ cell tumour (TGCT). Brothers of affected cases have an 8- to10-fold relative risk and fathers/sons have a risk between four ...