Now showing items 1-5 of 5

    • c-Myb regulates lineage choice in developing thymocytes via its target gene Gata3 

      Maurice, D; Hooper, J; Lang, G; Weston, K (NATURE PUBLISHING GROUP, 2007-08-08)
      During T-cell development, thymocytes with intermediate avidity for antigen-MHC complexes are positively selected and then differentiate into functional cytotoxic and helper T cells. This process is controlled by signalling ...
    • The hypoxic cancer secretome induces pre-metastatic bone lesions through lysyl oxidase 

      Cox, TR; Rumney, RMH; Schoof, EM; Perryman, L; Hoye, AM; Agrawal, A; Bird, D; Ab Latif, N; Forrest, H; Evans, HR; Huggins, ID; Lang, G; Linding, R; Gartland, A; Erler, JT (NATURE PUBLISHING GROUP, 2015-06-04)
      Tumour metastasis is a complex process involving reciprocal interplay between cancer cells and host stroma at both primary and secondary sites, and is strongly influenced by microenvironmental factors such as hypoxia(1). ...
    • LOX-Mediated Collagen Crosslinking Is Responsible for Fibrosis-Enhanced Metastasis 

      Cox, TR; Bird, D; Baker, A-M; Barker, HE; Ho, MW-Y; Lang, G; Erler, JT (AMER ASSOC CANCER RESEARCH, 2013-03-15)
      Tumor metastasis is a highly complex, dynamic, and inefficient process involving multiple steps, yet it accounts for more than 90% of cancer-related deaths. Although it has long been known that fibrotic signals enhance ...
    • Myb proteins regulate the expression of diverse target genes 

      Lang, G; White, JR; Argent-Katwala, MJG; Allinson, CG; Weston, K (NATURE PUBLISHING GROUP, 2005-02-17)
      Hematopoiesis, the process by which mature blood cells arise, is controlled by multiple transcription factors, which act in stage- and lineage-specific complexes. It is a major goal to elucidate the genes regulated by these ...
    • Tumor-Secreted LOXL2 Activates Fibroblasts through FAK Signaling 

      Barker, HE; Bird, D; Lang, G; Erler, JT (AMER ASSOC CANCER RESEARCH, 2013-11)
      Cancer-associated fibroblasts enhance cancer progression when activated by tumor cells through mechanisms not yet fully understood. Blocking mammary tumor cell-derived lysyl oxidase-like 2 (LOXL2) significantly inhibited ...