Browsing by author "Osuji, NNenna"
Now showing items 1-7 of 7
-
CD52 expression in T-cell large granular lymphocyte leukemia - Implications for treatment with alemtuzumab
(TAYLOR & FRANCIS LTD, 2005-05)Few reports on the successful treatment of T-cell large granular lymphocyte (LGL) leukemia with the humanized anti-CD52 monoclonal antibody alemtuzumab are emerging in the literature. The expression of CD52 by LGLs has not ... -
Granulomatous slack skin disease - disease features and response to pentostatin
(2003-10)Granulomatous slack skin disease (GSSD) is a rare condition characterized clinically by redundant skin folds, which show a predilection towards flexural areas, and histologically by a granulomatous T-cell infiltrate and ... -
IgVH genes mutation and usage, ZAP-70 and CD38 expression provide new insights on B-cell prolymphocytic leukemia (B-PLL)
(2006-07)B-prolymphocytic leukemia (B-PLL) is a rare disease with poor prognosis. To further characterize the biological features of this disease, we analyzed immunoglobulin heavy chain (IgVH) mutations, ZAP-70 and CD38 in 19 cases ... -
Lessons from a case of T-cell large granular lymphocytic leukaemia suggesting that immunomodulatory therapy is more effective than intensive treatment
(2005-02)Leukemia treatment strives to eradicate the malignant clone. With T-cell large granular lymphocytic (LGL) leukemia, the onus of treatment appears to be modification of the disease rather than eradication of the clone, We ... -
Pregnancy improves neutropenia in T-cell large granular lymphocyte leukaemia
(BLACKWELL PUBLISHING LTD, 2005-03)The effect of pregnancy on T-cell large granular lymphocyte (LGL) leukaemia has not been previously described. We retrospectively reviewed the clinical features of three patients with T-cell LGL leukaemia; each of them had ... -
Prolonged treatment response in aggressive natural killer cell leukemia
(TAYLOR & FRANCIS LTD, 2005-05)We describe a case of natural killer (NK) cell leukemia with acute presentation, systemic symptoms and hepatosplenomegaly. The uniform and aberrant phenotype of NK cells with infiltration of bone marrow and spleen was in ... -
Transformation of T-cell large granular lymphocyte leukaemia into a high-grade large T-cell lymphoma
(WILEY-BLACKWELL, 2001-12)We describe a case of T-cell large granular lymphocyte (LGL) leukaemia that transformed into a large-cell T-cell lymphoma 11 years from diagnosis. A 29-year-old asymptomatic female presented in 1989 with lymphocytosis, ...