Browsing by author "Vaughan,"
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A structural double-mutant cycle: estimating the strength of a buried salt bridge in barnase
Vaughan, CK; Harryson, P; Buckle, AM; Fersht, AR (2002-04)Double-mutant cycles are widely used in the field of protein engineering to measure intermolecular and intramolecular interactions. Ideally, there should be no structural rearrangement of the protein on making the two ...