Browsing by author "Wang, Anderson"
Now showing items 1-3 of 3
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BRD4 facilitates replication stress-induced DNA damage response.
Zhang, J; Dulak, AM; Hattersley, MM; Willis, BS; Nikkilä, J; et al. (NATURE PUBLISHING GROUP, 2018-07-12)Previous reports have demonstrated that select cancers depend on BRD4 to regulate oncogenic gene transcriptional programs. Here we describe a novel role for BRD4 in DNA damage response (DDR). BRD4 associates with and ... -
Distinct roles of BRCA2 in replication fork protection in response to hydroxyurea and DNA interstrand cross-links.
Rickman, KA; Noonan, RJ; Lach, FP; Sridhar, S; Wang, AT; et al. (COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT, 2020-06-01)DNA interstrand cross-links (ICLs) are a form of DNA damage that requires the interplay of a number of repair proteins including those of the Fanconi anemia (FA) and the homologous recombination (HR) pathways. Pathogenic ... -
SLFN11 informs on standard of care and novel treatments in a wide range of cancer models.
Winkler, C; Armenia, J; Jones, GN; Tobalina, L; Sale, MJ; et al. (SPRINGERNATURE, 2021-03-02)BACKGROUND: Schlafen 11 (SLFN11) has been linked with response to DNA-damaging agents (DDA) and PARP inhibitors. An in-depth understanding of several aspects of its role as a biomarker in cancer is missing, as is a ...