Browsing by author "Blagg, Julian"
Now showing items 1-3 of 3
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Donated chemical probes for open science.
Müller, S; Ackloo, S; Arrowsmith, CH; Bauser, M; Baryza, JL; et al. (2018-04-20)Potent, selective and broadly characterized small molecule modulators of protein function (chemical probes) are powerful research reagents. The pharmaceutical industry has generated many high-quality chemical probes and ... -
Dynamic Equilibrium of the Aurora A Kinase Activation Loop Revealed by Single-Molecule Spectroscopy.
Gilburt, JAH; Sarkar, H; Sheldrake, P; Blagg, J; Ying, L; et al. (2017-09)The conformation of the activation loop (T-loop) of protein kinases underlies enzymatic activity and influences the binding of small-molecule inhibitors. By using single-molecule fluorescence spectroscopy, we have determined ... -
Mapping the 3D structures of small molecule binding sites
Meyers, J; Brown, N; Blagg, J (BMC, 2016-12-06)