Now showing items 2097-2116 of 3194

    • P3.02c-030 Use of a 200-Mg Fixed Dose of Pembrolizumab for the Treatment of Advanced Non–Small Cell Lung Cancer (NSCLC) 

      Garon, E; Reck, M; Rodríguez-Abreu, D; Robinson, A; Hui, R; Tibor, C; Fülöp, A; Gottfried, M; Peled, N; Tafreshi, A; Cuffe, S; O'Brien, M; Rao, S; Hotta, K; Turner, D; Stone, J; Rangwala, R; Brahmer, J (Elsevier BV, 2017-01)
    • P3.05-006 Anxiolytic Effect of Acupuncture in a Phase II Study of Acupuncture and Morphine for Dyspnea in Lung Cancer and Mesothelioma 

      Minchom, A; Punwani, R; Filshie, J; Bhosle, J; Nimako, K; Myerson, J; Gunapala, R; Popat, S; O'Brien, M (Elsevier BV, 2017-01)
    • p53 and mdm2 in mantle cell lymphoma in leukemic phase 

      Solenthaler, M; Matutes, E; Brito-Babapulle, V; Morilla, R; Catovsky, D (FERRATA STORTI FOUNDATION, 2002-11)
      Background and Objectives. In mantle cell lymphoma (MCL), abnormalities additional to t(11;14) including those affecting genes involved in the p53 pathway, are important for disease-development and progression. This study ...
    • p53 immunochemistry is an independent prognostic marker for outcome in conservatively treated prostate cancer 

      Kudahetti, S; Fisher, G; Ambroisine, L; Foster, C; Reuter, V; Eastham, J; Moller, H; Kattan, MW; Cooper, CS; Scardino, P; Cuzick, J; Berney, DM; Grp, T-AP (WILEY-BLACKWELL PUBLISHING, INC, 2009-07)
      OBJECTIVE To determine whether p53 is an independent biomarker of prostate cancer outcome against currently used biomarkers in a cohort of conservatively treated prostate cancers with long-term follow-up available. PATIENTS ...
    • p53-dependent global nucleotide excision repair of cisplatin-induced intrastrand cross links in human cells 

      Bhana, S; Hewer, A; Phillips, DH; Lloyd, DR (OXFORD UNIV PRESS, 2008-03)
      Cisplatin is an extremely effective chemotherapeutic agent used for the treatment of testicular and other solid tumours. It induces a variety of structural modifications in DNA, the most abundant being the GpG- and ...
    • p66SHC-mediated mitochondrial dysfunction in renal proximal tubule cells during oxidative injury 

      Faisal, Amir (AMER PHYSIOLOGICAL SOC, 2010-05)
      Arany I, Faisal A, Clark JS, Vera T, Baliga R, Nagamine Y. p66SHC-mediated mitochondrial dysfunction in renal proximal tubule cells during oxidative injury. Am J Physiol Renal Physiol 298: F1214-F1221, 2010. First published ...
    • PACE-1, a novel protein that interacts with the C-terminal domain of ezrin. 

      Sullivan, A; Uff, CR; Isacke, CM; Thorne, RF (2003-04)
      The ERM proteins (ezrin, radixin, moesin) together with merlin comprise a subgroup of the band 4.1 superfamily. These proteins act as membrane cytoskeletal linker proteins mediating interactions between the cytoplasmic ...
    • Pain in cancer survivors; filling in the gaps 

      Brown, M; Farquhar-Smith, P (Elsevier BV, 2017-10)
    • Painful testicular metastasis from prostate adenocarcinoma. 

      Lee, KA; Mayer, E; Khoo, V (2017-12-05)
      A 60-year-old man presented with unilateral testicular pain and urinary frequency. His presenting prostate-specific antigen (PSA) was 100 ng/mL, and a biopsy revealed Gleason 4+4 prostate adenocarcinoma. The significance ...
    • PALB2, CHEK2 and ATM rare variants and cancer risk: data from COGS. 

      Southey, MC; Goldgar, DE; Winqvist, R; Pylkäs, K; Couch, F; Tischkowitz, M; Foulkes, WD; Dennis, J; Michailidou, K; van Rensburg, EJ; Heikkinen, T; Nevanlinna, H; Hopper, JL; Dörk, T; Claes, KB; Reis-Filho, J; Teo, ZL; Radice, P; Catucci, I; Peterlongo, P; Tsimiklis, H; Odefrey, FA; Dowty, JG; Schmidt, MK; Broeks, A; Hogervorst, FB; Verhoef, S; Carpenter, J; Clarke, C; Scott, RJ; Fasching, PA; Haeberle, L; Ekici, AB; Beckmann, MW; Peto, J; Dos-Santos-Silva, I; Fletcher, O; Johnson, N; Bolla, MK; Sawyer, EJ; Tomlinson, I; Kerin, MJ; Miller, N; Marme, F; Burwinkel, B; Yang, R; Guénel, P; Truong, T; Menegaux, F; Sanchez, M; Bojesen, S; Nielsen, SF; Flyger, H; Benitez, J; Zamora, MP; Perez, JI; Menéndez, P; Anton-Culver, H; Neuhausen, S; Ziogas, A; Clarke, CA; Brenner, H; Arndt, V; Stegmaier, C; Brauch, H; Brüning, T; Ko, YD; Muranen, TA; Aittomäki, K; Blomqvist, C; Bogdanova, NV; Antonenkova, NN; Lindblom, A; Margolin, S; Mannermaa, A; Kataja, V; Kosma, VM; Hartikainen, JM; Spurdle, AB; Investigators, K; Wauters, E; Smeets, D; Beuselinck, B; Floris, G; Chang-Claude, J; Rudolph, A; Seibold, P; Flesch-Janys, D; Olson, JE; Vachon, C; Pankratz, VS; McLean, C; Haiman, CA; Henderson, BE; Schumacher, F; Le Marchand, L; Kristensen, V; Alnæs, GG; Zheng, W; Hunter, DJ; Lindstrom, S; Hankinson, SE; Kraft, P; Andrulis, I; Knight, JA; Glendon, G; Mulligan, AM; Jukkola-Vuorinen, A; Grip, M; Kauppila, S; Devilee, P; Tollenaar, RA; Seynaeve, C; Hollestelle, A; Garcia-Closas, M; Figueroa, J; Chanock, SJ; Lissowska, J; Czene, K; Darabi, H; Eriksson, M; Eccles, DM; Rafiq, S; Tapper, WJ; Gerty, SM; Hooning, MJ; Martens, JW; Collée, JM; Tilanus-Linthorst, M; Hall, P; Li, J; Brand, JS; Humphreys, K; Cox, A; Reed, MW; Luccarini, C; Baynes, C; Dunning, AM; Hamann, U; Torres, D; Ulmer, HU; Rüdiger, T; Jakubowska, A; Lubinski, J; Jaworska, K; Durda, K; Slager, S; Toland, AE; Ambrosone, CB; Yannoukakos, D; Swerdlow, A; Ashworth, A; Orr, N; Jones, M; González-Neira, A; Pita, G; Alonso, MR; Álvarez, N; Herrero, D; Tessier, DC; Vincent, D; Bacot, F; Simard, J; Dumont, M; Soucy, P; Eeles, R; Muir, K; Wiklund, F; Gronberg, H; Schleutker, J; Nordestgaard, BG; Weischer, M; Travis, RC; Neal, D; Donovan, JL; Hamdy, FC; Khaw, KT; Stanford, JL; Blot, WJ; Thibodeau, S; Schaid, DJ; Kelley, JL; Maier, C; Kibel, AS; Cybulski, C; Cannon-Albright, L; Butterbach, K; Park, J; Kaneva, R; Batra, J; Teixeira, MR; Kote-Jarai, Z; Olama, AA; Benlloch, S; Renner, SP; Hartmann, A; Hein, A; Ruebner, M; Lambrechts, D; Van Nieuwenhuysen, E; Vergote, I; Lambretchs, S; Doherty, JA; Rossing, MA; Nickels, S; Eilber, U; Wang-Gohrke, S; Odunsi, K; Sucheston-Campbell, LE; Friel, G; Lurie, G; Killeen, JL; Wilkens, LR; Goodman, MT; Runnebaum, I; Hillemanns, PA; Pelttari, LM; Butzow, R; Modugno, F; Edwards, RP; Ness, RB; Moysich, KB; du Bois, A; Heitz, F; Harter, P; Kommoss, S; Karlan, BY; Walsh, C; Lester, J; Jensen, A; Kjaer, SK; Høgdall, E; Peissel, B; Bonanni, B; Bernard, L; Goode, EL; Fridley, BL; Vierkant, RA; Cunningham, JM; Larson, MC; Fogarty, ZC; Kalli, KR; Liang, D; Lu, KH; Hildebrandt, MA; Wu, X; Levine, DA; Dao, F; Bisogna, M; Berchuck, A; Iversen, ES; Marks, JR; Akushevich, L; Cramer, DW; Schildkraut, J; Terry, KL; Poole, EM; Stampfer, M; Tworoger, SS; Bandera, EV; Orlow, I; Olson, SH; Bjorge, L; Salvesen, HB; van Altena, AM; Aben, KK; Kiemeney, LA; Massuger, LF; Pejovic, T; Bean, Y; Brooks-Wilson, A; Kelemen, LE; Cook, LS; Le, ND; Górski, B; Gronwald, J; Menkiszak, J; Høgdall, CK; Lundvall, L; Nedergaard, L; Engelholm, SA; Dicks, E; Tyrer, J; Campbell, I; McNeish, I; Paul, J; Siddiqui, N; Glasspool, R; Whittemore, AS; Rothstein, JH; McGuire, V; Sieh, W; Cai, H; Shu, XO; Teten, RT; Sutphen, R; McLaughlin, JR; Narod, SA; Phelan, CM; Monteiro, AN; Fenstermacher, D; Lin, HY; Permuth, JB; Sellers, TA; Chen, YA; Tsai, YY; Chen, Z; Gentry-Maharaj, A; Gayther, SA; Ramus, SJ; Menon, U; Wu, AH; Pearce, CL; Van Den Berg, D; Pike, MC; Dansonka-Mieszkowska, A; Plisiecka-Halasa, J; Moes-Sosnowska, J; Kupryjanczyk, J; Pharoah, PD; Song, H; Winship, I; Chenevix-Trench, G; Giles, GG; Tavtigian, SV; Easton, DF; Milne, RL (2016-09-05)
      The rarity of mutations in PALB2, CHEK2 and ATM make it difficult to estimate precisely associated cancer risks. Population-based family studies have provided evidence that at least some of these mutations are associated ...
    • Palbociclib Combined with Fulvestrant in Premenopausal Women with Advanced Breast Cancer and Prior Progression on Endocrine Therapy: PALOMA-3 Results. 

      Loibl, S; Turner, NC; Ro, J; Cristofanilli, M; Iwata, H; Im, S-A; Masuda, N; Loi, S; André, F; Harbeck, N; Verma, S; Folkerd, E; Puyana Theall, K; Hoffman, J; Zhang, K; Bartlett, CH; Dowsett, M (2017-09)
      BACKGROUND: The efficacy and safety of palbociclib, a cyclin-dependent kinase 4/6 inhibitor, combined with fulvestrant and goserelin was assessed in premenopausal women with advanced breast cancer (ABC) who had progressed ...
    • Palbociclib in Combination With Fulvestrant in Women With Hormone Receptor-Positive/HER2-Negative Advanced Metastatic Breast Cancer: Detailed Safety Analysis From a Multicenter, Randomized, Placebo-Controlled, Phase III Study (PALOMA-3). 

      Verma, S; Bartlett, CH; Schnell, P; DeMichele, AM; Loi, S; Ro, J; Colleoni, M; Iwata, H; Harbeck, N; Cristofanilli, M; Zhang, K; Thiele, A; Turner, NC; Rugo, HS (2016-07)
      Palbociclib enhances endocrine therapy and improves clinical outcomes in hormone receptor (HR)-positive/human epidermal growth factor receptor 2 (HER2)-negative metastatic breast cancer (MBC). Because this is a new target, ...
    • A PAM50-Based Chemoendocrine Score for Hormone Receptor-Positive Breast Cancer with an Intermediate Risk of Relapse. 

      Prat, A; Lluch, A; Turnbull, AK; Dunbier, AK; Calvo, L; Albanell, J; de la Haba-Rodríguez, J; Arcusa, A; Chacón, JI; Sánchez-Rovira, P; Plazaola, A; Muñoz, M; Paré, L; Parker, JS; Ribelles, N; Jimenez, B; Bin Aiderus, AA; Caballero, R; Adamo, B; Dowsett, M; Carrasco, E; Martín, M; Dixon, JM; Perou, CM; Alba, E (2017-06-15)
      Purpose: Hormone receptor-positive (HR+) breast cancer is clinically and biologically heterogeneous, and subgroups with different prognostic and treatment sensitivities need to be identified.Experimental Design: Research-based ...
    • Pan-cancer analysis of the extent and consequences of intratumor heterogeneity 

      Andor, N; Graham, TA; Jansen, M; Xia, LC; Aktipis, CA; Petritsch, C; Ji, HP; Maley, CC (NATURE PUBLISHING GROUP, 2016-01)
      Intratumor heterogeneity (ITH) drives neoplastic progression and therapeutic resistance. We used the bioinformatics tools ‘expanding ploidy and allele frequency on nested subpopulations’ (EXPANDS) and PyClone to detect ...
    • PAN-EX: a pooled analysis of two trials of neoadjuvant chemotherapy followed by chemoradiotherapy in MRI-defined, locally advanced rectal cancer. 

      Sclafani, F; Brown, G; Cunningham, D; Wotherspoon, A; Tait, D; Peckitt, C; Evans, J; Yu, S; Sena Teixeira Mendes, L; Tabernero, J; Glimelius, B; Cervantes, A; Thomas, J; Begum, R; Oates, J; Chau, I (2016-08)
      EXPERT and EXPERT-C were phase II clinical trials of neoadjuvant chemotherapy (NACT) followed by chemoradiotherapy (CRT) in high-risk, locally advanced rectal cancer (LARC).We pooled individual patient data from these ...
    • Pancreatic Adenocarcinoma Gross Tumor Volume Contouring on Computed Tomography as Compared With Magnetic Resonance Imaging: Results of an International Consensus Contouring Conference 

      Hall, WA; Heerkens, HD; Paulson, ES; Meijer, GJ; Kotte, AN; Knechtges, P; Parikh, PJ; Bassetti, MF; Lee, P; Aitken, KL; Palta, M; Myrehaug, S; Koay, EJ; Portelance, L; Ben-Josef, E; Erickson, BA (Elsevier BV, 2017-10)
    • Paracrine-stimulated gene expression profile favors estradiol production in breast tumors. 

      Amin, SA; Huang, CC; Reierstad, S; Lin, Z; Arbieva, Z; Wiley, E; Saborian, H; Haynes, B; Cotterill, H; Dowsett, M; Bulun, SE (2006-07)
      Paracrine interactions between adipose fibroblasts and malignant epithelial cells are essential for structural and hormonal support of breast tumors. Factors derived from malignant epithelial cells inhibit adipogenic ...
    • A paradox: urgent BRCA genetic testing. 

      Mitchell, G; Ardern-Jones, A; Kissin Mchir, M; Taylor, R; Eeles, RA (2001-01)
      Diagnostic or predictive testing for germline mutations in cancer predisposition genes is inherently slow as result of both genetic counselling and mutation analysis. The overall time taken for mutation testing is not ...
    • Parallel RNAi and compound screens identify the PDK1 pathway as a target for tamoxifen sensitization. 

      Iorns, E; Lord, CJ; Ashworth, A (2009-01)
      Tamoxifen is the most commonly used drug to treat breast cancer and acts by blocking ERalpha (oestrogen receptor alpha) signalling. Although highly effective, its usefulness is limited by the development of resistance. ...
    • Parallel RNAi screens across different cell lines identify generic and cell type-specific regulators of actin organization and cell morphology 

      Sims, David (2009)
      Background: In recent years RNAi screening has proven a powerful tool for dissecting gene functions in animal cells in culture. However, to date, most RNAi screens have been performed in a single cell line, and results ...