Now showing items 1179-1198 of 3035

    • Germline variants in IL4, MGMT and AKT1 are associated with prostate cancer-specific mortality: An analysis of 12,082 prostate cancer cases. 

      FitzGerald, LM; Zhao, S; Leonardson, A; Geybels, MS; Kolb, S; Lin, DW; Wright, JL; Eeles, R; Kote-Jarai, Z; Govindasami, K; Giles, GG; Southey, MC; Schleutker, J; Tammela, TL; Sipeky, C; Penney, KL; Stampfer, MJ; Gronberg, H; Wiklund, F; Stattin, P; Hugosson, J; Karyadi, DM; Ostrander, EA; Feng, Z; Stanford, JL (2018-06)
      BACKGROUND: Prostate cancer (PCa) is a leading cause of mortality and genetic factors can influence tumour aggressiveness. Several germline variants have been associated with PCa-specific mortality (PCSM), but further ...
    • Germline variation at 8q24 and prostate cancer risk in men of European ancestry. 

      Matejcic, M; Saunders, EJ; Dadaev, T; Brook, MN; Wang, K; Sheng, X; Olama, AAA; Schumacher, FR; Ingles, SA; Govindasami, K; Benlloch, S; Berndt, SI; Albanes, D; Koutros, S; Muir, K; Stevens, VL; Gapstur, SM; Tangen, CM; Batra, J; Clements, J; Gronberg, H; Pashayan, N; Schleutker, J; Wolk, A; West, C; Mucci, L; Kraft, P; Cancel-Tassin, G; Sorensen, KD; Maehle, L; Grindedal, EM; Strom, SS; Neal, DE; Hamdy, FC; Donovan, JL; Travis, RC; Hamilton, RJ; Rosenstein, B; Lu, Y-J; Giles, GG; Kibel, AS; Vega, A; Bensen, JT; Kogevinas, M; Penney, KL; Park, JY; Stanford, JL; Cybulski, C; Nordestgaard, BG; Brenner, H; Maier, C; Kim, J; Teixeira, MR; Neuhausen, SL; De Ruyck, K; Razack, A; Newcomb, LF; Lessel, D; Kaneva, R; Usmani, N; Claessens, F; Townsend, PA; Gago-Dominguez, M; Roobol, MJ; Menegaux, F; Khaw, K-T; Cannon-Albright, LA; Pandha, H; Thibodeau, SN; Schaid, DJ; PRACTICAL (Prostate Cancer Association Group to Investigate Cancer-Associated Alterations in the Genome) Consortium; Wiklund, F; Chanock, SJ; Easton, DF; Eeles, RA; Kote-Jarai, Z; Conti, DV; Haiman, CA (2018-11-05)
      Chromosome 8q24 is a susceptibility locus for multiple cancers, including prostate cancer. Here we combine genetic data across the 8q24 susceptibility region from 71,535 prostate cancer cases and 52,935 controls of European ...
    • The Glioma International Case-Control Study: A Report From the Genetic Epidemiology of Glioma International Consortium. 

      Amirian, ES; Armstrong, GN; Zhou, R; Lau, CC; Claus, EB; Barnholtz-Sloan, JS; Il'yasova, D; Schildkraut, J; Ali-Osman, F; Sadetzki, S; Johansen, C; Houlston, RS; Jenkins, RB; Lachance, D; Olson, SH; Bernstein, JL; Merrell, RT; Wrensch, MR; Davis, FG; Lai, R; Shete, S; Amos, CI; Scheurer, ME; Aldape, K; Alafuzoff, I; Brännström, T; Broholm, H; Collins, P; Giannini, C; Rosenblum, M; Tihan, T; Melin, BS; Bondy, ML (2016-01)
      Decades of research have established only a few etiological factors for glioma, which is a rare and highly fatal brain cancer. Common methodological challenges among glioma studies include small sample sizes, heterogeneity ...
    • A Global Covariance Descriptor for Nuclear Atypia Scoring in Breast Histopathology Images 

      Khan, AM; Sirinukunwattana, K; Rajpoot, N (IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC, 2015-09)
      Nuclear atypia scoring is a diagnostic measure commonly used to assess tumor grade of various cancers, including breast cancer. It provides a quantitative measure of deviation in visual appearance of cell nuclei from those ...
    • Global geriatric oncology: Achievements and challenges 

      Soto-Perez-de-Celis, E; de Glas, NA; Hsu, T; Kanesvaran, R; Steer, C; Navarrete-Reyes, AP; Battisti, NML; Chavarri-Guerra, Y; O’Donovan, A; Avila-Funes, JA; Hurria, A (Elsevier BV, 2017-09)
    • Glucocorticoids inhibit apoptosis during fibrosarcoma development by transcriptionally activating Bcl-x(L) 

      Gascoyne, DM; Kypta, RM; Vivanco, MDM (AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 2003-05-16)
      Glucocorticoids influence many physiological processes, and in particular apoptosis, often with opposite effects depending on the cell type examined. We found that during fibrosarcoma development there is a strong increase ...
    • Glycogen synthase kinase 3 controls migration of the neural crest lineage in mouse and Xenopus. 

      Gonzalez Malagon, SG; Lopez Muñoz, AM; Doro, D; Bolger, TG; Poon, E; Tucker, ER; Adel Al-Lami, H; Krause, M; Phiel, CJ; Chesler, L; Liu, KJ (2018-03-19)
      Neural crest migration is critical to its physiological function. Mechanisms controlling mammalian neural crest migration are comparatively unknown, due to difficulties accessing this cell population in vivo. Here we report ...
    • Glycogen synthase kinase-3 and Axin function in a β-catenin-independent pathway that regulates neurite outgrowth in neuroblastoma cells 

      Orme, MH; Giannini, AL; Vivanco, MD; Kypta, RM (2003)
      We have sought to determine the roles of β-catenin and the Wnt signaling pathway in neurite outgrowth using a model cell system, the Neuro-2a neuroblastoma cell line. Activation of the Wnt signaling pathway disrupts a ...
    • Gold nanorod reshaping in vitro and in vivo using a continuous wave laser. 

      Harris-Birtill, D; Singh, M; Zhou, Y; Shah, A; Ruenraroengsak, P; Gallina, ME; Hanna, GB; Cass, AEG; Porter, AE; Bamber, J; Elson, DS (2017)
      Gold nanorods (GNRs) are increasingly being investigated for cancer theranostics as they possess features which lend themselves in equal measures as contrast agents and catalysts for photothermal therapy. Their optical ...
    • Granulomatous slack skin disease - disease features and response to pentostatin 

      Osuji, N; Fearfield, L; Matutes, E; Wotherspoon, AC; Bunker, C; Catovsky, D (2003-10)
      Granulomatous slack skin disease (GSSD) is a rare condition characterized clinically by redundant skin folds, which show a predilection towards flexural areas, and histologically by a granulomatous T-cell infiltrate and ...
    • GRASP65 and GRASP55 Sequentially Promote the Transport of C-terminal Valine-bearing Cargos to and through the Golgi Complex 

      Marra, PierFrancesco (AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 2009-12)
      The Golgi matrix proteins GRASP65 and GRASP55 have recognized roles in maintaining the architecture of the Golgi complex, in mitotic progression and in unconventional protein secretion whereas, surprisingly, they have been ...
    • Growth factor signalling and response to endocrine therapy: the Royal Marsden Experience. 

      Dowsett, M; Johnston, S; Martin, LA; Salter, J; Hills, M; Detre, S; Gutierrez, MC; Mohsin, SK; Shou, J; Allred, DC; Schiff, R; Osborne, CK; Smith, I (2005-07)
      De novo resistance to endocrine therapy is a near-universal feature of oestrogen receptor (ER)- negative breast cancer. Although many ER-positive breast cancers also show no response to tamoxifen or aromatase inhibitors ...
    • Growth factor-mediated induction of HDM2 positively regulates hypoxia-inducible factor 1 alpha expression 

      Bardos, JI; Chau, NM; Ashcroft, M (AMER SOC MICROBIOLOGY, 2004-04)
      The hypoxia-inducible factor 1 (HIF-1) transcriptional complex is regulated by cellular oxygen levels and growth factors. The phosphoinosotide 3-kinase (PI-3K)-Akt/protein kinase B (PKB) pathway has been shown to regulate ...
    • Growth kinetics in MCF-7 cells modulate benzo[a]pyrene-induced CYP1A1 up-regulation 

      Jiao, H; Allinson, SL; Walsh, MJ; Hewitt, R; Cole, KJ; Phillips, DH; Martin, FL (2007-03-01)
      Pro-carcinogens, such as benzo[a]pyrene (B[a]P), that are exogenous ligands of the aromatic hydrocarbon receptor may influence the susceptibility of target-cell populations through the up-regulation of cytochrome P450 (CYP) ...
    • Growth Trajectories, Breast Size, and Breast-Tissue Composition in a British Prebirth Cohort of Young Women. 

      Denholm, R; De Stavola, B; Hipwell, JH; Doran, SJ; Busana, MC; Leach, MO; Hawkes, DJ; Dos-Santos-Silva, I (2018-06-01)
      Mammographic percent density, the proportion of fibroglandular tissue in the breast, is a strong risk factor for breast cancer, but its determinants in young women are unknown. We examined associations of magnetic resonance ...
    • gsSKAT: Rapid gene set analysis and multiple testing correction for rare-variant association studies using weighted linear kernels. 

      Larson, NB; McDonnell, S; Cannon Albright, L; Teerlink, C; Stanford, J; Ostrander, EA; Isaacs, WB; Xu, J; Cooney, KA; Lange, E; Schleutker, J; Carpten, JD; Powell, I; Bailey-Wilson, JE; Cussenot, O; Cancel-Tassin, G; Giles, GG; MacInnis, RJ; Maier, C; Whittemore, AS; Hsieh, C-L; Wiklund, F; Catalona, WJ; Foulkes, W; Mandal, D; Eeles, R; Kote-Jarai, Z; Ackerman, MJ; Olson, TM; Klein, CJ; Thibodeau, SN; Schaid, DJ (2017-05)
      Next-generation sequencing technologies have afforded unprecedented characterization of low-frequency and rare genetic variation. Due to low power for single-variant testing, aggregative methods are commonly used to combine ...
    • GTI-2040 lorus therapeutics 

      Orr, Rosanne (2001)
    • Guidance Statement On BRCA1/2 Tumor Testing in Ovarian Cancer Patients. 

      Capoluongo, E; Ellison, G; López-Guerrero, JA; Penault-Llorca, F; Ligtenberg, MJL; Banerjee, S; Singer, C; Friedman, E; Markiefka, B; Schirmacher, P; Büttner, R; van Asperen, CJ; Ray-Coquard, I; Endris, V; Kamel-Reid, S; Percival, N; Bryce, J; Röthlisberger, B; Soong, R; de Castro, DG (2017-06)
      The approval, in 2015, of the first poly (adenosine diphosphate-ribose) polymerase inhibitor (PARPi; olaparib, Lynparza) for platinum-sensitive relapsed high-grade ovarian cancer with either germline or somatic BRCA1/2 ...
    • Guide to managing persistent upper gastrointestinal symptoms during and after treatment for cancer. 

      Andreyev, HJN; Muls, AC; Shaw, C; Jackson, RR; Gee, C; Vyoral, S; Davies, AR (2017-10)
      BACKGROUND: Guidance: the practical management of the gastrointestinal symptoms of pelvic radiation disease was published in 2014 for a multidisciplinary audience. Following this, a companion guide to managing upper ...
    • Guideline for PET/CT imaging of neuroendocrine neoplasms with 68Ga-DOTA-conjugated somatostatin receptor targeting peptides and 18F-DOPA. 

      Bozkurt, MF; Virgolini, I; Balogova, S; Beheshti, M; Rubello, D; Decristoforo, C; Ambrosini, V; Kjaer, A; Delgado-Bolton, R; Kunikowska, J; Oyen, WJG; Chiti, A; Giammarile, F; Sundin, A; Fanti, S (2017-08)
      PURPOSE & METHODS: Neuroendocrine neoplasms are a heterogenous group of tumours, for which nuclear medicine plays an important role in the diagnostic work-up as well as in the targeted therapeutic options. This guideline ...