Now showing items 1251-1270 of 3376

    • Genetic predisposition to B-cell acute lymphoblastic leukemia at 14q11.2 is mediated by a CEBPE promoter polymorphism. 

      Studd, JB; Yang, M; Li, Z; Vijayakrishnan, J; Lu, Y; Yeoh, AE-J; Paulsson, K; Houlston, RS (2019-01)
      Acute lymphoblastic leukaemia (ALL) is the most common paediatric malignancy. Genome-wide association studies have shown variation at 14q11.2 influences ALL risk. We sought to decipher causal variant(s) at 14q11.2 and the ...
    • Genetic Predisposition to Chronic Lymphocytic Leukemia Is Mediated by a BMF Super-Enhancer Polymorphism. 

      Kandaswamy, R; Sava, GP; Speedy, HE; Beà, S; Martín-Subero, JI; Studd, JB; Migliorini, G; Law, PJ; Puente, XS; Martín-García, D; Salaverria, I; Gutiérrez-Abril, J; López-Otín, C; Catovsky, D; Allan, JM; Campo, E; Houlston, RS (2016-08-11)
      Chronic lymphocytic leukemia (CLL) is an adult B cell malignancy. Genome-wide association studies show that variation at 15q15.1 influences CLL risk. We deciphered the causal variant at 15q15.1 and the mechanism by which ...
    • Genetic Predisposition to Multiple Myeloma at 5q15 Is Mediated by an ELL2 Enhancer Polymorphism. 

      Li, N; Johnson, DC; Weinhold, N; Kimber, S; Dobbins, SE; Mitchell, JS; Kinnersley, B; Sud, A; Law, PJ; Orlando, G; Scales, M; Wardell, CP; Försti, A; Hoang, PH; Went, M; Holroyd, A; Hariri, F; Pastinen, T; Meissner, T; Goldschmidt, H; Hemminki, K; Morgan, GJ; Kaiser, M; Houlston, RS (2017-09)
      Multiple myeloma (MM) is a malignancy of plasma cells. Genome-wide association studies have shown that variation at 5q15 influences MM risk. Here, we have sought to decipher the causal variant at 5q15 and the mechanism by ...
    • Genetic predisposition to prostate cancer. 

      Benafif, S; Eeles, R (2016-12)
      INTRODUCTION:Prostate cancer (PrCa) is the commonest non-cutaneous cancer in men in the UK. Epidemiological evidence as well as twin studies points towards a genetic component contributing to aetiology. SOURCES OF DATA:Key ...
    • Genetic predisposition to testicular germ-cell tumours. 

      Rapley, L (2004-06)
      Genetic predisposition to testicular germ-cell tumours Testicular germ-cell tumours (TGCT) are the most common neoplasm in young men. Various studies have suggested the existence of an inherited predisposition to development ...
    • Genetic Risk Score Mendelian Randomization Shows that Obesity Measured as Body Mass Index, but not Waist:Hip Ratio, Is Causal for Endometrial Cancer. 

      Painter, JN; O'Mara, TA; Marquart, L; Webb, PM; Attia, J; Medland, SE; Cheng, T; Dennis, J; Holliday, EG; McEvoy, M; Scott, RJ; Ahmed, S; Healey, CS; Shah, M; Gorman, M; Martin, L; Hodgson, SV; Beckmann, MW; Ekici, AB; Fasching, PA; Hein, A; Rübner, M; Czene, K; Darabi, H; Hall, P; Li, J; Dörk, T; Dürst, M; Hillemanns, P; Runnebaum, IB; Amant, F; Annibali, D; Depreeuw, J; Lambrechts, D; Neven, P; Cunningham, JM; Dowdy, SC; Goode, EL; Fridley, BL; Winham, SJ; Njølstad, TS; Salvesen, HB; Trovik, J; Werner, HMJ; Ashton, KA; Otton, G; Proietto, A; Mints, M; Tham, E; Bolla, MK; Michailidou, K; Wang, Q; Tyrer, JP; Hopper, JL; Peto, J; Swerdlow, AJ; Burwinkel, B; Brenner, H; Meindl, A; Brauch, H; Lindblom, A; Chang-Claude, J; Couch, FJ; Giles, GG; Kristensen, VN; Cox, A; Pharoah, PDP; Tomlinson, I; Dunning, AM; Easton, DF; Thompson, DJ; Spurdle, AB; AOCS Group; for RENDOCAS; National Study of Endometrial Cancer Genetics Group (NSECG); Australian National Endometrial Cancer Study Group (ANECS) (2016-11)
      The strongest known risk factor for endometrial cancer is obesity. To determine whether SNPs associated with increased body mass index (BMI) or waist-hip ratio (WHR) are associated with endometrial cancer risk, independent ...
    • A genetic study and meta-analysis of the genetic predisposition of prostate cancer in a Chinese population. 

      Marzec, J; Mao, X; Li, M; Wang, M; Feng, N; Gou, X; Wang, G; Sun, Z; Xu, J; Xu, H; Zhang, X; Zhao, S-C; Ren, G; Yu, Y; Wu, Y; Wu, J; Xue, Y; Zhou, B; Zhang, Y; Xu, X; Li, J; He, W; Benlloch, S; Ross-Adams, H; Chen, L; Li, J; Hong, Y; Kote-Jarai, Z; Cui, X; Hou, J; Guo, J; Xu, L; Yin, C; Zhou, Y; Neal, DE; Oliver, T; Cao, G; Zhang, Z; Easton, DF; Chelala, C; PRACTICAL Consortium; CHIPGECS Group; Al Olama, AA; Eeles, RA; Zhang, H; Lu, Y-J (2016-04)
      Prostate cancer predisposition has been extensively investigated in European populations, but there have been few studies of other ethnic groups. To investigate prostate cancer susceptibility in the under-investigated ...
    • Genetic susceptibility to radiation-induced breast cancer after Hodgkin lymphoma. 

      Opstal-van Winden, AWJ; de Haan, HG; Hauptmann, M; Schmidt, MK; Broeks, A; Russell, NS; Janus, CPM; Krol, ADG; van der Baan, FH; De Bruin, ML; van Eggermond, AM; Dennis, J; Anton-Culver, H; Haiman, CA; Sawyer, EJ; Cox, A; Devilee, P; Hooning, MJ; Peto, J; Couch, FJ; Pharoah, P; Orr, N; Easton, DF; Aleman, BMP; Strong, LC; Bhatia, S; Cooke, R; Robison, LL; Swerdlow, AJ; van Leeuwen, FE (2019-03)
      Female Hodgkin lymphoma (HL) patients treated with chest radiotherapy (RT) have a very high risk of breast cancer. The contribution of genetic factors to this risk is unclear. We therefore examined 211 155 germline ...
    • Genetic Testing and Clinical Management Practices for Variants in Non-BRCA1/2 Breast (and Breast/Ovarian) Cancer Susceptibility Genes: An International Survey by the Evidence-Based Network for the Interpretation of Germline Mutant Alleles (ENIGMA) Clinical Working Group. 

      Nielsen, SM; Eccles, DM; Romero, IL; Al-Mulla, F; Balmaña, J; Biancolella, M; Bslok, R; Caligo, MA; Calvello, M; Capone, GL; Cavalli, P; Chan, TLC; Claes, KBM; Cortesi, L; Couch, FJ; de la Hoya, M; De Toffol, S; Diez, O; Domchek, SM; Eeles, R; Efremidis, A; Fostira, F; Goldgar, D; Hadjisavvas, A; Hansen, TVO; Hirasawa, A; Houdayer, C; Kleiblova, P; Krieger, S; Lázaro, C; Loizidou, M; Manoukian, S; Mensenkamp, AR; Moghadasi, S; Monteiro, AN; Mori, L; Morrow, A; Naldi, N; Nielsen, HR; Olopade, OI; Pachter, NS; Palmero, EI; Pedersen, IS; Piane, M; Puzzo, M; Robson, M; Rossing, M; Sini, MC; Solano, A; Soukupova, J; Tedaldi, G; Teixeira, M; Thomassen, M; Tibiletti, MG; Toland, A; Törngren, T; Vaccari, E; Varesco, L; Vega, A; Wallis, Y; Wappenschmidt, B; Weitzel, J; Spurdle, AB; De Nicolo, A; Gómez-García, EB (2018-01)
      Purpose:To describe a snapshot of international genetic testing practices, specifically regarding the use of multigene panels, for hereditary breast/ovarian cancers. We conducted a survey through the Evidence-Based Network ...
    • Genetic testing for cancer predisposition and implications for nursing practice: narrative review 

      Bancroft, Elizabeth (WILEY-BLACKWELL PUBLISHING, INC, 2010-04)
      P>Title. Genetic testing for cancer predisposition and implications for nursing practice:narrative review. Aim. This paper is a report of a review of literature on the psychological and social implications of genetic testing ...
    • Genetic Tracing via DNGR-1 Expression History Defines Dendritic Cells as a Hematopoietic Lineage 

      Schraml, BU; van Blijswijk, J; Zelenay, S; Whitney, PG; Filby, A; Acton, SE; Rogers, NC; Moncaut, N; Carvajal, JJ; Reis e Sousa, C (CELL PRESS, 2013-08-15)
      Mononuclear phagocytes are classified as macrophages or dendritic cells (DCs) based on cell morphology, phenotype, or select functional properties. However, these attributes are not absolute and often overlap, leading to ...
    • Genetic Variants in Epigenetic Pathways and Risks of Multiple Cancers in the GAME-ON Consortium. 

      Toth, R; Scherer, D; Kelemen, LE; Risch, A; Hazra, A; Balavarca, Y; Issa, J-PJ; Moreno, V; Eeles, RA; Ogino, S; Wu, X; Ye, Y; Hung, RJ; Goode, EL; Ulrich, CM; OCAC, CORECT, TRICL, ELLIPSE, DRIVE, and GAME-ON consortia (2017-06)
      Background: Epigenetic disturbances are crucial in cancer initiation, potentially with pleiotropic effects, and may be influenced by the genetic background.Methods: In a subsets (ASSET) meta-analytic approach, we investigated ...
    • Genetic Variants Related to Longer Telomere Length are Associated with Increased Risk of Renal Cell Carcinoma. 

      Machiela, MJ; Hofmann, JN; Carreras-Torres, R; Brown, KM; Johansson, M; Wang, Z; Foll, M; Li, P; Rothman, N; Savage, SA; Gaborieau, V; McKay, JD; Ye, Y; Henrion, M; Bruinsma, F; Jordan, S; Severi, G; Hveem, K; Vatten, LJ; Fletcher, T; Koppova, K; Larsson, SC; Wolk, A; Banks, RE; Selby, PJ; Easton, DF; Pharoah, P; Andreotti, G; Freeman, LEB; Koutros, S; Albanes, D; Mannisto, S; Weinstein, S; Clark, PE; Edwards, TE; Lipworth, L; Gapstur, SM; Stevens, VL; Carol, H; Freedman, ML; Pomerantz, MM; Cho, E; Kraft, P; Preston, MA; Wilson, KM; Gaziano, JM; Sesso, HS; Black, A; Freedman, ND; Huang, W-Y; Anema, JG; Kahnoski, RJ; Lane, BR; Noyes, SL; Petillo, D; Colli, LM; Sampson, JN; Besse, C; Blanche, H; Boland, A; Burdette, L; Prokhortchouk, E; Skryabin, KG; Yeager, M; Mijuskovic, M; Ognjanovic, M; Foretova, L; Holcatova, I; Janout, V; Mates, D; Mukeriya, A; Rascu, S; Zaridze, D; Bencko, V; Cybulski, C; Fabianova, E; Jinga, V; Lissowska, J; Lubinski, J; Navratilova, M; Rudnai, P; Szeszenia-Dabrowska, N; Benhamou, S; Cancel-Tassin, G; Cussenot, O; Bueno-de-Mesquita, HB; Canzian, F; Duell, EJ; Ljungberg, B; Sitaram, RT; Peters, U; White, E; Anderson, GL; Johnson, L; Luo, J; Buring, J; Lee, I-M; Chow, W-H; Moore, LE; Wood, C; Eisen, T; Larkin, J; Choueiri, TK; Lathrop, GM; Teh, BT; Deleuze, J-F; Wu, X; Houlston, RS; Brennan, P; Chanock, SJ; Scelo, G; Purdue, MP (2017-11)
      BACKGROUND:Relative telomere length in peripheral blood leukocytes has been evaluated as a potential biomarker for renal cell carcinoma (RCC) risk in several studies, with conflicting findings. OBJECTIVE:We performed an ...
    • Genetic variation at CYP3A is associated with age at menarche and breast cancer risk: a case-control study. 

      Johnson, N; Dudbridge, F; Orr, N; Gibson, L; Jones, ME; Schoemaker, MJ; Folkerd, EJ; Haynes, BP; Hopper, JL; Southey, MC; Dite, GS; Apicella, C; Schmidt, MK; Broeks, A; Van't Veer, LJ; Atsma, F; Muir, K; Lophatananon, A; Fasching, PA; Beckmann, MW; Ekici, AB; Renner, SP; Sawyer, E; Tomlinson, I; Kerin, M; Miller, N; Burwinkel, B; Marme, F; Schneeweiss, A; Sohn, C; Guénel, P; Truong, T; Cordina, E; Menegaux, F; Bojesen, SE; Nordestgaard, BG; Flyger, H; Milne, R; Zamora, MP; Arias Perez, JI; Benitez, J; Bernstein, L; Anton-Culver, H; Ziogas, A; Clarke Dur, C; Brenner, H; Müller, H; Arndt, V; Dieffenbach, AK; Meindl, A; Heil, J; Bartram, CR; Schmutzler, RK; Brauch, H; Justenhoven, C; Ko, Y-D; GENICA (Gene Environment Interaction and Breast Cancer in Germany) Network; Nevanlinna, H; Muranen, TA; Aittomäki, K; Blomqvist, C; Matsuo, K; Dörk, T; Bogdanova, NV; Antonenkova, NN; Lindblom, A; Mannermaa, A; Kataja, V; Kosma, V-M; Hartikainen, JM; Chenevix-Trench, G; Beesley, J; kConFab Investigators; Australian Ovarian Cancer Study Group; Wu, AH; Van den Berg, D; Tseng, C-C; Lambrechts, D; Smeets, D; Neven, P; Wildiers, H; Chang-Claude, J; Rudolph, A; Nickels, S; Flesch-Janys, D; Radice, P; Peterlongo, P; Bonanni, B; Pensotti, V; Couch, FJ; Olson, JE; Wang, X; Fredericksen, Z; Pankratz, VS; Giles, GG; Severi, G; Baglietto, L; Haiman, C; Simard, J; Goldberg, MS; Labrèche, F; Dumont, M; Soucy, P; Teo, S; Yip, CH; Phuah, SY; Cornes, BK; Kristensen, VN; Grenaker Alnæs, G; Børresen-Dale, A-L; Zheng, W; Winqvist, R; Pylkäs, K; Jukkola-Vuorinen, A; Grip, M; Andrulis, IL; Knight, JA; Glendon, G; Mulligan, AM; Devillee, P; Figueroa, J; Chanock, SJ; Lissowska, J; Sherman, ME; Hall, P; Schoof, N; Hooning, M; Hollestelle, A; Oldenburg, RA; Tilanus-Linthorst, M; Liu, J; Cox, A; Brock, IW; Reed, MWR; Cross, SS; Blot, W; Signorello, LB; Pharoah, PDP; Dunning, AM; Shah, M; Kang, D; Noh, D-Y; Park, SK; Choi, J-Y; Hartman, M; Miao, H; Lim, WY; Tang, A; Hamann, U; Försti, A; Rüdiger, T; Ulmer, HU; Jakubowska, A; Lubinski, J; Jaworska-Bieniek, K; Durda, K; Sangrajrang, S; Gaborieau, V; Brennan, P; McKay, J; Slager, S; Toland, AE; Vachon, C; Yannoukakos, D; Shen, C-Y; Yu, J-C; Huang, C-S; Hou, M-F; González-Neira, A; Tessier, DC; Vincent, D; Bacot, F; Luccarini, C; Dennis, J; Michailidou, K; Bolla, MK; Wang, J; Easton, DF; García-Closas, M; Dowsett, M; Ashworth, A; Swerdlow, AJ; Peto, J; dos Santos Silva, I; Fletcher, O (2014-05-26)
      INTRODUCTION:We have previously shown that a tag single nucleotide polymorphism (rs10235235), which maps to the CYP3A locus (7q22.1), was associated with a reduction in premenopausal urinary estrone glucuronide levels and ...
    • Genetically modified lentiviruses that preserve microvascular function protect against late radiation damage in normal tissues. 

      Khan, AA; Paget, JT; McLaughlin, M; Kyula, JN; Wilkinson, MJ; Pencavel, T; Mansfield, D; Roulstone, V; Seth, R; Halle, M; Somaiah, N; Boult, JKR; Robinson, SP; Pandha, HS; Vile, RG; Melcher, AA; Harris, PA; Harrington, KJ (2018-01)
      Improvements in cancer survival mean that long-term toxicities, which contribute to the morbidity of cancer survivorship, are being increasingly recognized. Late adverse effects (LAEs) in normal tissues after radiotherapy ...
    • Genetically Predicted Body Mass Index and Breast Cancer Risk: Mendelian Randomization Analyses of Data from 145,000 Women of European Descent. 

      Guo, Y; Warren Andersen, S; Shu, X-O; Michailidou, K; Bolla, MK; Wang, Q; Garcia-Closas, M; Milne, RL; Schmidt, MK; Chang-Claude, J; Dunning, A; Bojesen, SE; Ahsan, H; Aittomäki, K; Andrulis, IL; Anton-Culver, H; Arndt, V; Beckmann, MW; Beeghly-Fadiel, A; Benitez, J; Bogdanova, NV; Bonanni, B; Børresen-Dale, A-L; Brand, J; Brauch, H; Brenner, H; Brüning, T; Burwinkel, B; Casey, G; Chenevix-Trench, G; Couch, FJ; Cox, A; Cross, SS; Czene, K; Devilee, P; Dörk, T; Dumont, M; Fasching, PA; Figueroa, J; Flesch-Janys, D; Fletcher, O; Flyger, H; Fostira, F; Gammon, M; Giles, GG; Guénel, P; Haiman, CA; Hamann, U; Hooning, MJ; Hopper, JL; Jakubowska, A; Jasmine, F; Jenkins, M; John, EM; Johnson, N; Jones, ME; Kabisch, M; Kibriya, M; Knight, JA; Koppert, LB; Kosma, V-M; Kristensen, V; Le Marchand, L; Lee, E; Li, J; Lindblom, A; Luben, R; Lubinski, J; Malone, KE; Mannermaa, A; Margolin, S; Marme, F; McLean, C; Meijers-Heijboer, H; Meindl, A; Neuhausen, SL; Nevanlinna, H; Neven, P; Olson, JE; Perez, JIA; Perkins, B; Peterlongo, P; Phillips, K-A; Pylkäs, K; Rudolph, A; Santella, R; Sawyer, EJ; Schmutzler, RK; Seynaeve, C; Shah, M; Shrubsole, MJ; Southey, MC; Swerdlow, AJ; Toland, AE; Tomlinson, I; Torres, D; Truong, T; Ursin, G; Van Der Luijt, RB; Verhoef, S; Whittemore, AS; Winqvist, R; Zhao, H; Zhao, S; Hall, P; Simard, J; Kraft, P; Pharoah, P; Hunter, D; Easton, DF; Zheng, W (2016-08-23)
      Observational epidemiological studies have shown that high body mass index (BMI) is associated with a reduced risk of breast cancer in premenopausal women but an increased risk in postmenopausal women. It is unclear whether ...
    • The GENIE Is Out of the Bottle: Landmark Cancer Genomics Dataset Released. 

      Litchfield, K; Turajlic, S; Swanton, C (2017-08)
      <b/> In this issue of Cancer Discovery, an overview of the AACR Project GENIE, a landmark study in cancer genomics, is presented by The AACR Project GENIE Consortium. A summary of the goals and objectives of this ambitious ...
    • Genome-wide and high-density CRISPR-Cas9 screens identify point mutations in PARP1 causing PARP inhibitor resistance. 

      Pettitt, SJ; Krastev, DB; Brandsma, I; Dréan, A; Song, F; Aleksandrov, R; Harrell, MI; Menon, M; Brough, R; Campbell, J; Frankum, J; Ranes, M; Pemberton, HN; Rafiq, R; Fenwick, K; Swain, A; Guettler, S; Lee, J-M; Swisher, EM; Stoynov, S; Yusa, K; Ashworth, A; Lord, CJ (2018-05-10)
      Although PARP inhibitors (PARPi) target homologous recombination defective tumours, drug resistance frequently emerges, often via poorly understood mechanisms. Here, using genome-wide and high-density CRISPR-Cas9 ...
    • Genome-wide association analysis identifies a meningioma risk locus at 11p15.5. 

      Claus, EB; Cornish, AJ; Broderick, P; Schildkraut, JM; Dobbins, SE; Holroyd, A; Calvocoressi, L; Lu, L; Hansen, HM; Smirnov, I; Walsh, KM; Schramm, J; Hoffmann, P; Nöthen, MM; Jöckel, K-H; Swerdlow, A; Larsen, SB; Johansen, C; Simon, M; Bondy, M; Wrensch, M; Houlston, RS; Wiemels, JL (2018-10)
      Background:Meningiomas are adult brain tumors originating in the meningeal coverings of the brain and spinal cord, with significant heritable basis. Genome-wide association studies (GWAS) have previously identified only a ...
    • Genome-wide association analysis implicates dysregulation of immunity genes in chronic lymphocytic leukaemia. 

      Law, PJ; Berndt, SI; Speedy, HE; Camp, NJ; Sava, GP; Skibola, CF; Holroyd, A; Joseph, V; Sunter, NJ; Nieters, A; Bea, S; Monnereau, A; Martin-Garcia, D; Goldin, LR; Clot, G; Teras, LR; Quintela, I; Birmann, BM; Jayne, S; Cozen, W; Majid, A; Smedby, KE; Lan, Q; Dearden, C; Brooks-Wilson, AR; Hall, AG; Purdue, MP; Mainou-Fowler, T; Vajdic, CM; Jackson, GH; Cocco, P; Marr, H; Zhang, Y; Zheng, T; Giles, GG; Lawrence, C; Call, TG; Liebow, M; Melbye, M; Glimelius, B; Mansouri, L; Glenn, M; Curtin, K; Diver, WR; Link, BK; Conde, L; Bracci, PM; Holly, EA; Jackson, RD; Tinker, LF; Benavente, Y; Boffetta, P; Brennan, P; Maynadie, M; McKay, J; Albanes, D; Weinstein, S; Wang, Z; Caporaso, NE; Morton, LM; Severson, RK; Riboli, E; Vineis, P; Vermeulen, RCH; Southey, MC; Milne, RL; Clavel, J; Topka, S; Spinelli, JJ; Kraft, P; Ennas, MG; Summerfield, G; Ferri, GM; Harris, RJ; Miligi, L; Pettitt, AR; North, KE; Allsup, DJ; Fraumeni, JF; Bailey, JR; Offit, K; Pratt, G; Hjalgrim, H; Pepper, C; Chanock, SJ; Fegan, C; Rosenquist, R; de Sanjose, S; Carracedo, A; Dyer, MJS; Catovsky, D; Campo, E; Cerhan, JR; Allan, JM; Rothman, N; Houlston, R; Slager, S (2017-02-06)
      Several chronic lymphocytic leukaemia (CLL) susceptibility loci have been reported; however, much of the heritable risk remains unidentified. Here we perform a meta-analysis of six genome-wide association studies, imputed ...