Now showing items 1688-1707 of 4352

    • Germline sequencing DNA repair genes in 5,545 men with aggressive and non-aggressive prostate cancer. 

      Darst, BF; Dadaev, T; Saunders, E; Sheng, X; Wan, P; Pooler, L; Xia, LY; Chanock, S; Berndt, SI; Gapstur, SM; Stevens, V; Albanes, D; Weinstein, SJ; Gnanapragasam, V; Giles, GG; Nguyen-Dumont, T; Milne, RL; Pomerantz, M; Schmidt, JA; Mucci, L; Catalona, WJ; Hetrick, KN; Doheny, KF; MacInnis, RJ; Southey, MC; Eeles, RA; Wiklund, F; Kote-Jarai, Z; Conti, DV; Haiman, CA (2020-08-27)
      <h4>Background</h4>There is an urgent need to identify factors specifically associated with aggressive prostate cancer (PCa) risk. We investigated whether rare pathogenic, likely pathogenic, or deleterious (P/LP/D) germline ...
    • Germline variants in IL4, MGMT and AKT1 are associated with prostate cancer-specific mortality: An analysis of 12,082 prostate cancer cases. 

      FitzGerald, LM; Zhao, S; Leonardson, A; Geybels, MS; Kolb, S; Lin, DW; Wright, JL; Eeles, R; Kote-Jarai, Z; Govindasami, K; Giles, GG; Southey, MC; Schleutker, J; Tammela, TL; Sipeky, C; Penney, KL; Stampfer, MJ; Gronberg, H; Wiklund, F; Stattin, P; Hugosson, J; Karyadi, DM; Ostrander, EA; Feng, Z; Stanford, JL (2018-06)
      BACKGROUND:Prostate cancer (PCa) is a leading cause of mortality and genetic factors can influence tumour aggressiveness. Several germline variants have been associated with PCa-specific mortality (PCSM), but further ...
    • Germline variation at 8q24 and prostate cancer risk in men of European ancestry. 

      Matejcic, M; Saunders, EJ; Dadaev, T; Brook, MN; Wang, K; Sheng, X; Olama, AAA; Schumacher, FR; Ingles, SA; Govindasami, K; Benlloch, S; Berndt, SI; Albanes, D; Koutros, S; Muir, K; Stevens, VL; Gapstur, SM; Tangen, CM; Batra, J; Clements, J; Gronberg, H; Pashayan, N; Schleutker, J; Wolk, A; West, C; Mucci, L; Kraft, P; Cancel-Tassin, G; Sorensen, KD; Maehle, L; Grindedal, EM; Strom, SS; Neal, DE; Hamdy, FC; Donovan, JL; Travis, RC; Hamilton, RJ; Rosenstein, B; Lu, Y-J; Giles, GG; Kibel, AS; Vega, A; Bensen, JT; Kogevinas, M; Penney, KL; Park, JY; Stanford, JL; Cybulski, C; Nordestgaard, BG; Brenner, H; Maier, C; Kim, J; Teixeira, MR; Neuhausen, SL; De Ruyck, K; Razack, A; Newcomb, LF; Lessel, D; Kaneva, R; Usmani, N; Claessens, F; Townsend, PA; Gago-Dominguez, M; Roobol, MJ; Menegaux, F; Khaw, K-T; Cannon-Albright, LA; Pandha, H; Thibodeau, SN; Schaid, DJ; PRACTICAL (Prostate Cancer Association Group to Investigate Cancer-Associated Alterations in the Genome) Consortium; Wiklund, F; Chanock, SJ; Easton, DF; Eeles, RA; Kote-Jarai, Z; Conti, DV; Haiman, CA (2018-11-05)
      Chromosome 8q24 is a susceptibility locus for multiple cancers, including prostate cancer. Here we combine genetic data across the 8q24 susceptibility region from 71,535 prostate cancer cases and 52,935 controls of European ...
    • Germline-focussed analysis of tumour-only sequencing: recommendations from the ESMO Precision Medicine Working Group. 

      Mandelker, D; Donoghue, M; Talukdar, S; Bandlamudi, C; Srinivasan, P; Vivek, M; Jezdic, S; Hanson, H; Snape, K; Kulkarni, A; Hawkes, L; Douillard, J-Y; Wallace, SE; Rial-Sebbag, E; Meric-Bersntam, F; George, A; Chubb, D; Loveday, C; Ladanyi, M; Berger, MF; Taylor, BS; Turnbull, C (2019-08)
      It is increasingly common in oncology practice to perform tumour sequencing using large cancer panels. For pathogenic sequence variants in cancer susceptibility genes identified on tumour-only sequencing, it is often unclear ...
    • The Glioma International Case-Control Study: A Report From the Genetic Epidemiology of Glioma International Consortium. 

      Amirian, ES; Armstrong, GN; Zhou, R; Lau, CC; Claus, EB; Barnholtz-Sloan, JS; Il'yasova, D; Schildkraut, J; Ali-Osman, F; Sadetzki, S; Johansen, C; Houlston, RS; Jenkins, RB; Lachance, D; Olson, SH; Bernstein, JL; Merrell, RT; Wrensch, MR; Davis, FG; Lai, R; Shete, S; Amos, CI; Scheurer, ME; Aldape, K; Alafuzoff, I; Brännström, T; Broholm, H; Collins, P; Giannini, C; Rosenblum, M; Tihan, T; Melin, BS; Bondy, ML (2016-01)
      Decades of research have established only a few etiological factors for glioma, which is a rare and highly fatal brain cancer. Common methodological challenges among glioma studies include small sample sizes, heterogeneity ...
    • Glioma risk associated with extent of estimated European genetic ancestry in African Americans and Hispanics. 

      Ostrom, QT; Egan, KM; Nabors, LB; Gerke, T; Thompson, RC; Olson, JJ; LaRocca, R; Chowdhary, S; Eckel-Passow, JE; Armstrong, G; Wiencke, JK; Bernstein, JL; Claus, EB; Il'yasova, D; Johansen, C; Lachance, DH; Lai, RK; Merrell, RT; Olson, SH; Sadetzki, S; Schildkraut, JM; Shete, S; Houlston, RS; Jenkins, RB; Wrensch, MR; Melin, B; Amos, CI; Huse, JT; Barnholtz-Sloan, JS; Bondy, ML (2020-02)
      Glioma incidence is highest in non-Hispanic Whites, and to date, glioma genome-wide association studies (GWAS) to date have only included European ancestry (EA) populations. African Americans and Hispanics in the US have ...
    • Glioma-related seizures in relation to histopathological subtypes: a report from the glioma international case-control study. 

      Berntsson, SG; Merrell, RT; Amirian, ES; Armstrong, GN; Lachance, D; Smits, A; Zhou, R; Jacobs, DI; Wrensch, MR; Olson, SH; Il'yasova, D; Claus, EB; Barnholtz-Sloan, JS; Schildkraut, J; Sadetzki, S; Johansen, C; Houlston, RS; Jenkins, RB; Bernstein, JL; Lai, R; Shete, S; Amos, CI; Bondy, ML; Melin, BS (2018-06)
      BACKGROUND:The purpose of this study was to evaluate the distribution of glioma-related seizures and seizure control at the time of tumor diagnosis with respect to tumor histologic subtypes, tumor treatment and patient ...
    • A Global Covariance Descriptor for Nuclear Atypia Scoring in Breast Histopathology Images 

      Khan, AM; Sirinukunwattana, K; Rajpoot, N (IEEE-INST ELECTRICAL ELECTRONICS ENGINEERS INC, 2015-09)
      Nuclear atypia scoring is a diagnostic measure commonly used to assess tumor grade of various cancers, including breast cancer. It provides a quantitative measure of deviation in visual appearance of cell nuclei from those ...
    • Global geriatric oncology: Achievements and challenges. 

      Soto-Perez-de-Celis, E; de Glas, NA; Hsu, T; Kanesvaran, R; Steer, C; Navarrete-Reyes, AP; Battisti, NML; Chavarri-Guerra, Y; O'Donovan, A; Avila-Funes, JA; Hurria, A (2017-09)
      The aging of the population is a global challenge. The number of older adults is rapidly growing, leading to an increase in the prevalence of noncommunicable diseases associated with aging, such as cancer. Worldwide, older ...
    • Global treatment patterns and outcomes among patients with recurrent and/or metastatic head and neck squamous cell carcinoma: Results of the GLANCE H&N study. 

      Grünwald, V; Chirovsky, D; Cheung, WY; Bertolini, F; Ahn, M-J; Yang, M-H; Castro, G; Berrocal, A; Sjoquist, K; Kuyas, H; Auclair, V; Guillaume, X; Joo, S; Shah, R; Harrington, K; GLANCE H&N STUDY Investigators (2020-03)
      OBJECTIVES:Given a lack of universally-accepted standard-of-care treatment for patients with recurrent/metastatic head and neck squamous cell carcinoma (R/M HNSCC), study objectives were to assess treatment utilization and ...
    • Global, site-specific analysis of neuronal protein S-acylation. 

      Collins, MO; Woodley, KT; Choudhary, JS (2017-07-05)
      Protein S-acylation (palmitoylation) is a reversible lipid modification that is an important regulator of dynamic membrane-protein interactions. Proteomic approaches have uncovered many putative palmitoylated proteins ...
    • Glucocorticoids inhibit apoptosis during fibrosarcoma development by transcriptionally activating Bcl-x(L) 

      Gascoyne, DM; Kypta, RM; Vivanco, MDM (AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 2003-05-16)
      Glucocorticoids influence many physiological processes, and in particular apoptosis, often with opposite effects depending on the cell type examined. We found that during fibrosarcoma development there is a strong increase ...
    • Glutathione Metabolism: An Achilles' Heel of ARID1A-Deficient Tumors. 

      Gorrini, C; Mak, TW (2019-02)
      In this issue of Cancer Cell, Ogiwara et al. describe a novel link between the epigenetic regulator ARID1A and glutathione metabolism in cancer that is mediated by regulation of the cystine/glutamate transporter XCT. This ...
    • Glutathione Primes T Cell Metabolism for Inflammation. 

      Mak, TW; Grusdat, M; Duncan, GS; Dostert, C; Nonnenmacher, Y; Cox, M; Binsfeld, C; Hao, Z; Brüstle, A; Itsumi, M; Jäger, C; Chen, Y; Pinkenburg, O; Camara, B; Ollert, M; Bindslev-Jensen, C; Vasiliou, V; Gorrini, C; Lang, PA; Lohoff, M; Harris, IS; Hiller, K; Brenner, D (2017-04)
      Activated T cells produce reactive oxygen species (ROS), which trigger the antioxidative glutathione (GSH) response necessary to buffer rising ROS and prevent cellular damage. We report that GSH is essential for T cell ...
    • Glycogen synthase kinase 3 controls migration of the neural crest lineage in mouse and Xenopus. 

      Gonzalez Malagon, SG; Lopez Muñoz, AM; Doro, D; Bolger, TG; Poon, E; Tucker, ER; Adel Al-Lami, H; Krause, M; Phiel, CJ; Chesler, L; Liu, KJ (2018-03-19)
      Neural crest migration is critical to its physiological function. Mechanisms controlling mammalian neural crest migration are comparatively unknown, due to difficulties accessing this cell population in vivo. Here we report ...
    • Glycogen synthase kinase-3 and Axin function in a β-catenin-independent pathway that regulates neurite outgrowth in neuroblastoma cells 

      Orme, MH; Giannini, AL; Vivanco, MD; Kypta, RM (2003)
      We have sought to determine the roles of β-catenin and the Wnt signaling pathway in neurite outgrowth using a model cell system, the Neuro-2a neuroblastoma cell line. Activation of the Wnt signaling pathway disrupts a ...
    • Gold nanorod reshaping in vitro and in vivo using a continuous wave laser. 

      Harris-Birtill, D; Singh, M; Zhou, Y; Shah, A; Ruenraroengsak, P; Gallina, ME; Hanna, GB; Cass, AEG; Porter, AE; Bamber, J; Elson, DS (2017-01)
      Gold nanorods (GNRs) are increasingly being investigated for cancer theranostics as they possess features which lend themselves in equal measures as contrast agents and catalysts for photothermal therapy. Their optical ...
    • Granulocyte colony-stimulating factor and autologous CD133-positive stem-cell therapy in liver cirrhosis (REALISTIC): an open-label, randomised, controlled phase 2 trial. 

      Newsome, PN; Fox, R; King, AL; Barton, D; Than, N-N; Moore, J; Corbett, C; Townsend, S; Thomas, J; Guo, K; Hull, D; Beard, HA; Thompson, J; Atkinson, A; Bienek, C; McGowan, N; Guha, N; Campbell, J; Hollyman, D; Stocken, D; Yap, C; Forbes, SJ (2018-01)
      <h4>Background</h4>Results of small-scale studies have suggested that stem-cell therapy is safe and effective in patients with liver cirrhosis, but no adequately powered randomised controlled trials have been done. We ...
    • Granulomatous slack skin disease - disease features and response to pentostatin 

      Osuji, N; Fearfield, L; Matutes, E; Wotherspoon, AC; Bunker, C; Catovsky, D (2003-10)
      Granulomatous slack skin disease (GSSD) is a rare condition characterized clinically by redundant skin folds, which show a predilection towards flexural areas, and histologically by a granulomatous T-cell infiltrate and ...
    • GRASP65 and GRASP55 Sequentially Promote the Transport of C-terminal Valine-bearing Cargos to and through the Golgi Complex 

      Marra, PierFrancesco (AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC, 2009-12)
      The Golgi matrix proteins GRASP65 and GRASP55 have recognized roles in maintaining the architecture of the Golgi complex, in mitotic progression and in unconventional protein secretion whereas, surprisingly, they have been ...