Now showing items 1831-1850 of 3076

    • Mutational signatures of ionizing radiation in second malignancies. 

      Behjati, S; Gundem, G; Wedge, DC; Roberts, ND; Tarpey, PS; Cooke, SL; Van Loo, P; Alexandrov, LB; Ramakrishna, M; Davies, H; Nik-Zainal, S; Hardy, C; Latimer, C; Raine, KM; Stebbings, L; Menzies, A; Jones, D; Shepherd, R; Butler, AP; Teague, JW; Jorgensen, M; Khatri, B; Pillay, N; Shlien, A; Futreal, PA; Badie, C; ICGC Prostate Group; McDermott, U; Bova, GS; Richardson, AL; Flanagan, AM; Stratton, MR; Campbell, PJ (2016-09-12)
      Ionizing radiation is a potent carcinogen, inducing cancer through DNA damage. The signatures of mutations arising in human tissues following in vivo exposure to ionizing radiation have not been documented. Here, we searched ...
    • Mutational spectrum in a worldwide study of 29,700 families with BRCA1 or BRCA2 mutations. 

      Rebbeck, TR; Friebel, TM; Friedman, E; Hamann, U; Huo, D; Kwong, A; Olah, E; Olopade, OI; Solano, AR; Teo, S-H; Thomassen, M; Weitzel, JN; Chan, TL; Couch, FJ; Goldgar, DE; Kruse, TA; Palmero, EI; Park, SK; Torres, D; van Rensburg, EJ; McGuffog, L; Parsons, MT; Leslie, G; Aalfs, CM; Abugattas, J; Adlard, J; Agata, S; Aittomäki, K; Andrews, L; Andrulis, IL; Arason, A; Arnold, N; Arun, BK; Asseryanis, E; Auerbach, L; Azzollini, J; Balmaña, J; Barile, M; Barkardottir, RB; Barrowdale, D; Benitez, J; Berger, A; Berger, R; Blanco, AM; Blazer, KR; Blok, MJ; Bonadona, V; Bonanni, B; Bradbury, AR; Brewer, C; Buecher, B; Buys, SS; Caldes, T; Caliebe, A; Caligo, MA; Campbell, I; Caputo, SM; Chiquette, J; Chung, WK; Claes, KBM; Collée, JM; Cook, J; Davidson, R; de la Hoya, M; De Leeneer, K; de Pauw, A; Delnatte, C; Diez, O; Ding, YC; Ditsch, N; Domchek, SM; Dorfling, CM; Velazquez, C; Dworniczak, B; Eason, J; Easton, DF; Eeles, R; Ehrencrona, H; Ejlertsen, B; EMBRACE; Engel, C; Engert, S; Evans, DG; Faivre, L; Feliubadaló, L; Ferrer, SF; Foretova, L; Fowler, J; Frost, D; Galvão, HCR; Ganz, PA; Garber, J; Gauthier-Villars, M; Gehrig, A; GEMO Study Collaborators; Gerdes, A-M; Gesta, P; Giannini, G; Giraud, S; Glendon, G; Godwin, AK; Greene, MH; Gronwald, J; Gutierrez-Barrera, A; Hahnen, E; Hauke, J; HEBON; Henderson, A; Hentschel, J; Hogervorst, FBL; Honisch, E; Imyanitov, EN; Isaacs, C; Izatt, L; Izquierdo, A; Jakubowska, A; James, P; Janavicius, R; Jensen, UB; John, EM; Vijai, J; Kaczmarek, K; Karlan, BY; Kast, K; Investigators, K; Kim, S-W; Konstantopoulou, I; Korach, J; Laitman, Y; Lasa, A; Lasset, C; Lázaro, C; Lee, A; Lee, MH; Lester, J; Lesueur, F; Liljegren, A; Lindor, NM; Longy, M; Loud, JT; Lu, KH; Lubinski, J; Machackova, E; Manoukian, S; Mari, V; Martínez-Bouzas, C; Matrai, Z; Mebirouk, N; Meijers-Heijboer, HEJ; Meindl, A; Mensenkamp, AR; Mickys, U; Miller, A; Montagna, M; Moysich, KB; Mulligan, AM; Musinsky, J; Neuhausen, SL; Nevanlinna, H; Ngeow, J; Nguyen, HP; Niederacher, D; Nielsen, HR; Nielsen, FC; Nussbaum, RL; Offit, K; Öfverholm, A; Ong, K-R; Osorio, A; Papi, L; Papp, J; Pasini, B; Pedersen, IS; Peixoto, A; Peruga, N; Peterlongo, P; Pohl, E; Pradhan, N; Prajzendanc, K; Prieur, F; Pujol, P; Radice, P; Ramus, SJ; Rantala, J; Rashid, MU; Rhiem, K; Robson, M; Rodriguez, GC; Rogers, MT; Rudaitis, V; Schmidt, AY; Schmutzler, RK; Senter, L; Shah, PD; Sharma, P; Side, LE; Simard, J; Singer, CF; Skytte, A-B; Slavin, TP; Snape, K; Sobol, H; Southey, M; Steele, L; Steinemann, D; Sukiennicki, G; Sutter, C; Szabo, CI; Tan, YY; Teixeira, MR; Terry, MB; Teulé, A; Thomas, A; Thull, DL; Tischkowitz, M; Tognazzo, S; Toland, AE; Topka, S; Trainer, AH; Tung, N; van Asperen, CJ; van der Hout, AH; van der Kolk, LE; van der Luijt, RB; Van Heetvelde, M; Varesco, L; Varon-Mateeva, R; Vega, A; Villarreal-Garza, C; von Wachenfeldt, A; Walker, L; Wang-Gohrke, S; Wappenschmidt, B; Weber, BHF; Yannoukakos, D; Yoon, S-Y; Zanzottera, C; Zidan, J; Zorn, KK; Hutten Selkirk, CG; Hulick, PJ; Chenevix-Trench, G; Spurdle, AB; Antoniou, AC; Nathanson, KL (2018-05)
      The prevalence and spectrum of germline mutations in BRCA1 and BRCA2 have been reported in single populations, with the majority of reports focused on White in Europe and North America. The Consortium of Investigators of ...
    • Mutations in Epigenetic Regulation Genes Are a Major Cause of Overgrowth with Intellectual Disability. 

      Tatton-Brown, K; Loveday, C; Yost, S; Clarke, M; Ramsay, E; Zachariou, A; Elliott, A; Wylie, H; Ardissone, A; Rittinger, O; Stewart, F; Temple, IK; Cole, T; Childhood Overgrowth Collaboration; Mahamdallie, S; Seal, S; Ruark, E; Rahman, N (2017-05-04)
      To explore the genetic architecture of human overgrowth syndromes and human growth control, we performed experimental and bioinformatic analyses of 710 individuals with overgrowth (height and/or head circumference ≥+2 SD) ...
    • Mutations in UPF3B, a member of the nonsense-mediated mRNA decay complex, cause syndromic and nonsyndromic mental retardation 

      Stratton, M (2007-09)
      Nonsense- mediated mRNA decay ( NMD) is of universal biological significance(1-3). It has emerged as an important global RNA, DNA and translation regulatory pathway(4). By systematically sequencing 737 genes ( annotated ...
    • Myb proteins regulate expression of histone variant H2A.Z during thymocyte development 

      Hooper, J; Maurice, D; Argent-Katwala, MJG; Weston, K (BLACKWELL PUBLISHING, 2008-02)
      The c-myb gene encodes a transcription factor required for the normal development of T cells in the thymus, and for subsequent peripheral T-cell activation and survival. However, the profile of genes known to be transcriptionally ...
    • Myb proteins regulate the expression of diverse target genes 

      Lang, G; White, JR; Argent-Katwala, MJG; Allinson, CG; Weston, K (NATURE PUBLISHING GROUP, 2005-02-17)
      Hematopoiesis, the process by which mature blood cells arise, is controlled by multiple transcription factors, which act in stage- and lineage-specific complexes. It is a major goal to elucidate the genes regulated by these ...
    • Myoepithelial Carcinoma of the Paracecal Mesentery: Aggressive Behavior of a Rare Neoplasm at an Unusual Anatomic Site. 

      Thway, K; Noujaim, J; Thomas, DM; Fisher, C; Jones, RL (2017-03-24)
      Myoepithelial tumors of the soft tissues represent a rare group of neoplasms that vary in their clinical behavior, pathologic features and genetics. They are histopathologically typified by a myoepithelial immunohistochemical ...
    • The Myogenic Factor Myf5 Supports Efficient Skeletal Muscle Regeneration by Enabling Transient Myoblast Amplification 

      Ustanina, S; Carvajal, J; Rigby, P; Braun, T (Wiley-Blackwell, 2009-01-02)
      Abstract The myogenic factor Myf5 defines the onset of myogenesis in mammals during development. Mice lacking both Myf5 and MyoD fail to form myoblasts and are characterized by a complete absence of skeletal muscle at ...
    • Myosin and Actin Filaments in Muscle: Structures and Interactions. 

      Squire, JM; Paul, DM; Morris, EP (2017)
      In the last decade, improvements in electron microscopy and image processing have permitted significantly higher resolutions to be achieved (sometimes <1 nm) when studying isolated actin and myosin filaments. In the case ...
    • A N-15 NMR investigation of a series of benzotriazinones and related antitumour heterocycles 

      Vaughan, K; Wilman, DEV; Wheelhouse, RT; Stevens, MFG (2002-04)
      A series of 3-substituted 1,2,3-benzotriazin-4-ones, 1 and 2, were synthesized by standard methods and the N-15 NMR spectra were recorded. All spectra were obtained using the natural abundance of the nitrogen-15 isotope. ...
    • N-acetyltransferase and sulfotransferase activity in human prostate: potential for carcinogen activation 

      Al-Buheissi, SZ; Patel, HR; Meinl, W; Hewer, A; Bryan, RL; Glatt, H; Miller, RA; Phillips, DH (LIPPINCOTT WILLIAMS & WILKINS, 2006-06)
      Background N-Acetyltransferases (NATs) and sulfotransferases (SULTs) are key phase 11 metabolizing enzymes that can be involved both in the detoxification and in the activation of many human promutagens and procarcinogens. ...
    • N-acetyltransferases, sulfotransferases and heterocyclic amine activation in the breast 

      Williams, JA; Stone, EM; Fakis, G; Johnson, N; Cordell, JA; Meinl, W; Glatt, H; Sim, E; Phillips, DH (LIPPINCOTT WILLIAMS & WILKINS, 2001-07)
    • Nanostructures from Synthetic Genetic Polymers. 

      Taylor, AI; Beuron, F; Peak-Chew, SY; Morris, EP; Herdewijn, P; Holliger, P (2016-06)
      Nanoscale objects of increasing complexity can be constructed from DNA or RNA. However, the scope of potential applications could be enhanced by expanding beyond the moderate chemical diversity of natural nucleic acids. ...
    • A narrow deletion of 7q is common to HCL, and SMZL, but not CLL 

      Andersen, CL; Gruszka-Westwood, A; Ostergaard, M; Koch, J; Jacobsen, E; Kjeldsen, E; Nielsen, B (BLACKWELL MUNKSGAARD, 2004-06)
      To further characterise the genetic background of the two closely related B-lymphocytic malignancies hairy cell leukaemia (HCL), and splenic marginal zone lymphoma (SMZL) we have identified characteristic copy number ...
    • The National Cancer Institute Cohort Consortium: An International Pooling Collaboration of 58 Cohorts from 20 Countries. 

      Swerdlow, AJ; Harvey, CE; Milne, RL; Pottinger, CA; Vachon, CM; Wilkens, LR; Gapstur, SM; Johansson, M; Weiderpass, E; Winn, DM (2018-11)
      Cohort studies have been central to the establishment of the known causes of cancer. To dissect cancer etiology in more detail-for instance, for personalized risk prediction and prevention, assessment of risks of subtypes ...
    • National implementation of multi-parametric magnetic resonance imaging for prostate cancer detection - recommendations from a UK consensus meeting. 

      Brizmohun Appayya, M; Adshead, J; Ahmed, HU; Allen, C; Bainbridge, A; Barrett, T; Giganti, F; Graham, J; Haslam, P; Johnston, EW; Kastner, C; Kirkham, APS; Lipton, A; McNeill, A; Moniz, L; Moore, CM; Nabi, G; Padhani, AR; Parker, C; Patel, A; Pursey, J; Richenberg, J; Staffurth, J; van der Meulen, J; Walls, D; Punwani, S (2018-07)
      OBJECTIVES: To identify areas of agreement and disagreement in the implementation of multi-parametric magnetic resonance imaging (mpMRI) of the prostate in the diagnostic pathway. MATERIALS AND METHODS: Fifteen UK experts ...
    • The National Institute for Health and Care Excellence (NICE) Guidance on Bladder Cancer; a Step in the Right Direction? 

      Trainor, S; Choudhury, A; Huddart, R; Kiltie, AE; Kockelbergh, R; Turner, W; Birtle, A; Crabb, SJ (2017-06)
    • The National Lung Matrix Trial: translating the biology of stratification in advanced non-small-cell lung cancer. 

      Middleton, G; Crack, LR; Popat, S; Swanton, C; Hollingsworth, SJ; Buller, R; Walker, I; Carr, TH; Wherton, D; Billingham, LJ (2015-12)
      The management of NSCLC has been transformed by stratified medicine. The National Lung Matrix Trial (NLMT) is a UK-wide study exploring the activity of rationally selected biomarker/targeted therapy combinations.The Cancer ...
    • Nationwide trends in the incidence and outcome of patients with gastrointestinal stromal tumour in the imatinib era. 

      van der Graaf, WTA; Tielen, R; Bonenkamp, JJ; Lemmens, V; Verhoeven, RHA; de Wilt, JHW (2018-07)
      BACKGROUND: The incidence, treatment and outcome of patients with newly diagnosed gastrointestinal stromal tumour (GIST) were studied in an era known for advances in diagnosis and treatment. METHODS: Nationwide population-based ...
    • Natural Selection in Cancer Biology: From Molecular Snowflakes to Trait Hallmarks 

      Maley, Carlo (2017-02)
      Evolution by natural selection is the conceptual foundation for nearly every branch of biology and increasingly also for biomedicine and medical research. In cancer biology, evolution explains how populations of cells in ...