Now showing items 1936-1955 of 3822

    • Landscape of somatic mutations in 560 breast cancer whole-genome sequences. 

      Nik-Zainal, S; Davies, H; Staaf, J; Ramakrishna, M; Glodzik, D; Zou, X; Martincorena, I; Alexandrov, LB; Martin, S; Wedge, DC; Van Loo, P; Ju, YS; Smid, M; Brinkman, AB; Morganella, S; Aure, MR; Lingjærde, OC; Langerød, A; Ringnér, M; Ahn, S-M; Boyault, S; Brock, JE; Broeks, A; Butler, A; Desmedt, C; Dirix, L; Dronov, S; Fatima, A; Foekens, JA; Gerstung, M; Hooijer, GKJ; Jang, SJ; Jones, DR; Kim, H-Y; King, TA; Krishnamurthy, S; Lee, HJ; Lee, J-Y; Li, Y; McLaren, S; Menzies, A; Mustonen, V; O'Meara, S; Pauporté, I; Pivot, X; Purdie, CA; Raine, K; Ramakrishnan, K; Rodríguez-González, FG; Romieu, G; Sieuwerts, AM; Simpson, PT; Shepherd, R; Stebbings, L; Stefansson, OA; Teague, J; Tommasi, S; Treilleux, I; Van den Eynden, GG; Vermeulen, P; Vincent-Salomon, A; Yates, L; Caldas, C; van't Veer, L; Tutt, A; Knappskog, S; Tan, BKT; Jonkers, J; Borg, Å; Ueno, NT; Sotiriou, C; Viari, A; Futreal, PA; Campbell, PJ; Span, PN; Van Laere, S; Lakhani, SR; Eyfjord, JE; Thompson, AM; Birney, E; Stunnenberg, HG; van de Vijver, MJ; Martens, JWM; Børresen-Dale, A-L; Richardson, AL; Kong, G; Thomas, G; Stratton, MR (2016-06)
      We analysed whole-genome sequences of 560 breast cancers to advance understanding of the driver mutations conferring clonal advantage and the mutational processes generating somatic mutations. We found that 93 protein-coding ...
    • Landscape of the Plasmodium Interactome Reveals Both Conserved and Species-Specific Functionality. 

      Hillier, C; Pardo, M; Yu, L; Bushell, E; Sanderson, T; Metcalf, T; Herd, C; Anar, B; Rayner, JC; Billker, O; Choudhary, JS (2019-08)
      Malaria represents a major global health issue, and the identification of new intervention targets remains an urgent priority. This search is hampered by more than one-third of the genes of malaria-causing Plasmodium ...
    • The landscape of tyrosine kinase inhibitors in sarcomas: looking beyond pazopanib. 

      Wilding, CP; Elms, ML; Judson, I; Tan, A-C; Jones, RL; Huang, PH (2019-11-13)
      Introduction: Tyrosine kinases are key mediators of intracellular signaling cascades and aberrations in these proteins have been implicated in driving oncogenesis through the dysregulation of fundamental cellular processes ...
    • Large expert-curated database for benchmarking document similarity detection in biomedical literature search 

      Brown, P; Tan, A-C; El-Esawi, MA; Liehr, T; Blanck, O; Gladue, DP; Almeida, GMF; Cernava, T; Sorzano, CO; Yeung, AWK; Engel, MS; Chandrasekaran, AR; Muth, T; Staege, MS; Daulatabad, SV; Widera, D; Zhang, J; Meule, A; Honjo, K; Pourret, O; Yin, C-C; Zhang, Z; Cascella, M; Flegel, WA; Goodyear, CS; van Raaij, MJ; Bukowy-Bieryllo, Z; Campana, LG; Kurniawan, NA; Lalaouna, D; Huttner, FJ; Ammerman, BA; Ehret, F; Cobine, PA; Tan, E-C; Han, H; Xia, W; McCrum, C; Dings, RPM; Marinello, F; Nilsson, H; Nixon, B; Voskarides, K; Yang, L; Costa, VD; Bengtsson-Palme, J; Bradshaw, W; Grimm, DG; Kumar, N; Martis, E; Prieto, D; Sabnis, SC; Amer, SEDR; Liew, AWC; Perco, P; Rahimi, F; Riva, G; Zhang, C; Devkota, HP; Ogami, K; Basharat, Z; Fierz, W; Siebers, R; Tan, K-H; Boehme, KA; Brenneisen, P; Brown, JAL; Dalrymple, BP; Harvey, DJ; Ng, G; Werten, S; Bleackley, M; Dai, Z; Dhariwal, R; Gelfer, Y; Hartmann, MD; Miotla, P; Tamaian, R; Govender, P; Gurney-Champion, OJ; Kauppila, JH; Zhang, X; Echeverria, N; Subhash, S; Sallmon, H; Tofani, M; Bae, T; Bosch, O; Cuiv, PO; Danchin, A; Diouf, B; Eerola, T; Evangelou, E; Filipp, FV; Klump, H; Kurgan, L; Smith, SS; Terrier, O; Tuttle, N; Ascher, DB; Janga, SC; Schulte, LN; Becker, D; Browngardt, C; Bush, SJ; Gaullier, G; Ide, K; Meseko, C; Werner, GDA; Zaucha, J; Al-Farha, AA; Greenwald, NF; Popoola, SI; Rahman, MS; Xu, J; Yang, SY; Hiroi, N; Alper, OM; Baker, CI; Bitzer, M; Chacko, G; Debrabant, B; Dixon, R; Forano, E; Gilliham, M; Kelly, S; Klempnauer, K-H; Lidbury, BA; Lin, MZ; Lynch, I; Ma, W; Maibach, EW; Mather, DE; Nandakumar, KS; Ohgami, RS; Parchi, P; Tressoldi, P; Xue, Y; Armitage, C; Barraud, P; Chatzitheochari, S; Coelho, LP; Diao, J; Doxey, AC; Gobet, A; Hu, P; Kaiser, S; Mitchell, KM; Salama, MF; Shabalin, IG; Song, H; Stevanovic, D; Yadollahpour, A; Zeng, E; Zinke, K; Alimba, CG; Beyene, TJ; Cao, Z; Chan, SS; Gatchell, M; Kleppe, A; Piotrowski, M; Torga, G; Woldesemayat, AA; Cosacak, MI; Haston, S; Ross, SA; Williams, R; Wong, A; 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Zhao, X; Ziegler, A; Aizat, WM; Atlas, L; Bridges, KM; Chakraborty, S; Deschodt, M; Domingues, HS; Esfahlani, SS; Falk, S; Guisado, JL; Kane, NC; Kueberuwa, G; Lau, CL; Liang, D; Liu, E; Luu, AM; Ma, C; Ma, L; Moyer, R; Norris, AD; Panthee, S; Parsons, JR; Peng, Y; Pinto, IM; Reschke, CR; Sillanpaa, E; Stewart, CJ; Uhle, F; Yang, H; Zhou, K; Zhu, S; Ashry, M; Bergsland, N; Berthold, M; Chen, C-E; Colella, V; Cuypers, M; Eskew, EA; Fan, X; Gajda, M; Gonzalezlez-Prendes, R; Goodin, A; Graham, EB; Groen, EJN; Gutierrez-Sacristan, A; Habes, M; Heffler, E; Higginbottom, DB; Janzen, T; Jayaraman, J; Jibb, LA; Jongen, S; Kinyanjui, T; Koleva-Kolarova, RG; Li, Z; Liu, Y-P; Lund, BA; Lussier, AA; Ma, L; Mier, P; Moore, MD; Nagler, K; Orme, MW; Pearson, JA; Prajapati, AS; Saito, Y; Troder, SE; Uchendu, F; Verloh, N; Voutchkova, DD; Abu-Zaid, A; Bakkach, J; Baumert, P; Dono, M; Hanson, J; Herbelet, S; Hobbs, E; Kulkarni, A; Kumar, N; Liu, S; Loft, ND; Reddan, T; Senghore, T; Vindin, H; Xu, H; Bannon, R; Chen, B; Cheung, JTK; Cooper, J; Esnakul, AK; Feghali, KA; Ghelardi, E; Gnasso, A; Horbar, J; Lai, HM; Li, J; Ma, L; Ma, R; Pan, Z; Peres, MA; Pranata, R; Seow, E; Sydes, M; Testoni, I; Westermair, AL; Yang, Y; Afnan, M; Albiol, J; Albuquerque, LG; Amiya, E; Amorim, RM; An, Q; Andersen, SU; Aplin, JD; Argyropoulos, C; Asmann, YW; Assaeed, AM; Atanasov, AG; Atchison, DA; Avery, SV; Avillach, P; Baade, PD; Backman, L; Badie, C; Baldi, A; Ball, E; Bardot, O; Barnett, AG; Basner, M; Batra, J; Bazanova, OM; Beale, A; Beddoe, T; Bell, ML; Berezikov, E; Berners-Price, S; Bernhardt, P; Berry, E; Bessa, TB; Billington, C; Birch, J; Blakely, RD; Blaskovich, MAT; Blum, R; Boelaert, M; Bogdanos, D; Bosch, C; Bourgoin, T; Bouvard, D; Boykin, LM; Bradley, G; Braun, D; Brownlie, J; Bruhl, A; Burt, A; Butler, LM; Byrareddy, SN; Byrne, HJ; Cabantous, S; Calatayud, S; Candal, E; Carlson, K; Casillas, S; Castelvetro, V; Caswell, PT; Cavalli, G; Cerovsky, V; Chagoyen, M; Chen, C-S; Chen, DF; Chen, H; Chen, H; 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Leem, JW; Leightley, D; Leite, A; Lercher, L; Li, Y; Lim, R; Lima, LRA; Lin, L; Ling, T; Liu, Y; Liu, Z; Lu, Y; Lum, FM; Luo, H; Machhi, J; Macleod, A; Macwan, I; Madala, HR; Madani, N; de Maio, N; Makowiecki, K; Mallinson, DJ; Margelyte, R; Maria, C; Markonis, Y; Marsili, L; Mavoa, S; McWilliams, L; Megersa, M; Mendes, CSM; Menichetti, J; Mercieca-Bebber, R; Miller, JJ; Minde, D-PM; Minges, A; Mishra, E; Mishra, VR; Moores, C; Morrice, N; Moskalensky, AE; Navarin, N; Negera, E; Nolet, P; Nordberg, A; Norden, R; Nowicki, JP; Olova, N; Olszewski, P; Onzima, R; Pan, C-L; Park, C; Park, DI; Park, S; Patil, CD; Pedro, SA; Perry, SR; Peter, J; Peterson, BM; Pezzuolo, A; Pozdnyakov, I; Qian, S; Qin, L; Rafe, A; Raote, I; Raza, A; Rebl, H; Refai, O; Regan, T; Richa, T; Richardson, MF; Robinson, KR; Rossoni, L; Rouet, R; Safaei, S; Schneeberger, PHH; Schwotzer, D; Sebastian, A; Selinski, J; Seltmann, S; Sha, F; Shalev, N; Shang, J-L; Singer, J; Singh, M; Smith, T; Solomon-Moore, E; Song, L; Soraggi, S; Stanley, R; Steckhan, N; Strobl, F; Subissi, L; Supriyanto, I; Surve, CR; Suzuki, T; Syme, C; Sorelius, K; Tang, Y; Tantawy, M; Tennakoon, S; Teseo, S; Toelzer, C; Tomov, N; Tovar, M; Tran, L; Tripathi, S; Tuladhar, AM; Ukubuiwe, AC; Ung, COL; Valgepea, K; Vatanparast, H; Vidal, A; Wang, F; Wang, Q; Watari, R; Webster, R; Webster, R; Wei, J; Wibowo, D; Wingenbach, TSH; Xavier, RM; Xiao, S; Xiong, P; Xu, S; Xu, S; Yao, R; Yao, W; Yin, Q; Yu, Y; Zaitsu, M; Zeineb, Z; Zhan, X-Y; Zhang, J; Zhang, R; Zhang, W; Zhang, X; Zheng, S; Zhou, B; Zhou, X; Ahmad, H; Akinwumi, SA; Albery, GF; Alhowimel, A; Ali, J; Alshehri, M; Alsuhaibani, M; Anikin, A; Azubuike, SO; Bach-Mortensen, A; Baltiansky, L; Bartas, M; Belachew, KY; Bhardwaj, V; Binder, K; Bland, NS; Boah, M; Bullen, B; Calabro, GE; Callahan, TJ; Cao, B; Chalmers, K; Chang, W; Che, Z; Chen, ATY; Chen, H; Chen, H; Chen, Y; Chen, Z; Choi, Y; Chowdhury, MAK; Christensen, MR; Cooke, RSC; Cottini, M; Covington, NV; Cunningham, C; Delarocque, J; Devos, L; Dhar, AR; Ding, K-F; Dong, K; Dong, Z; Dreyer, N; Ekstrand, C; Fardet, T; Feleke, BE; Feurer, T; Freitas, A; Gao, T; Asefa, NG; Giganti, F; Grabowski, P; Guerra-Mora, JR; Guo, C; Guo, X; Gupta, H; He, S; Heijne, M; Heinemann, S; Hogrebe, A; Huang, Z; Iskander-Rizk, S; Iyer, LM; Jahan, Y; James, AS; Joel, E; Joffroy, B; Jegousse, C; Kambondo, G; Karnati, P; Kaya, C; Ke, A; Kelly, D; Kickert, R; Kidibule, PE; Kieselmann, JP; Kim, HJ; Kitazawa, T; Lamberts, A; Li, Y; Liang, H; Linn, SN; Litfin, T; Liusuo, W; Lygirou, V; Mahato, AK; Mai, Z-M; Major, RW; Mali, S; Mallis, P; Mao, W; Mao, W; Marvin-Dowle, K; Marvin-Dowle, K; Mason, LD; Merideth, B; Merino-Plaza, MJ; Merlaen, B; Messina, R; Mishra, AK; Muhammad, J; Musinguzi, C; Nanou, A; Naqash, A; Nguyen, JT; Nguyen, TTH; Ni, D; Nida; Notcovich, S; Ohst, B; Ollivier, QR; Osses, DF; Peng, X; Plantinga, A; Pulia, M; Rafiq, M; Raman, A; Raucher-Chene, D; Rawski, R; Ray, A; Razak, LA; Rudolf, K; Rusch, P; Sadoine, ML; Schmidt, A; Schurr, R; Searles, S; Sharma, S; Sheehan, B; Shi, C; Shohayeb, B; Sommerlad, A; Strehlow, J; Sun, X; Sundar, R; Taherzadeh, G; Tahir, NDM; Tang, J; Testa, J; Tian, Z; Tingting, Q; Verheijen, GP; Vickstrom, C; Wang, T; Wang, X; Wang, Z; Wei, P; Wilson, A; Wyart; Yassine, A-A; Yousefzadeh, A; Zare, A; Zeng, Z; Zhang, C; Zhang, H; Zhang, L; Zhang, T; Zhang, W; Zhang, Z; Zhou, J; Zhu, D; Adamo, V; Adeyemo, AA; Aggelidou, M; Al-Owaifeer, AM; Al-Riyami, AZ; Alzghari, SK; Andersen, V; Angus, K; Asaduzzaman, M; Asady, H; Ato, D; Bai, X; Baines, RL; Ballantyne, M; Ban, B; Beck, J; Ben-Nafa, W; Black, E; Blancher, A; Blankstein, R; Bodagh, N; Borges, PAV; Brooks, A; Brox-Ponce, J; Brunetti, A; Canham, CD; Carninci, P; Carvajal, R; Chang, SC; Chao, J; Chatterjee, P; Chen, H; Chen, Y-C; Chhatriwalla, AK; Chikowe, I; Chuang, T-J; Collevatti, RG; Valera-Cornejo, DA; Cuenda, A; Dao, M; Dauga, D; Deng, Z; Devkota, K; Doan, LV; Elewa, YHA; Fan, D; Faruk, M; Feifei, S; Ferguson, TS; Fleres, F; Foster, EJ; Foster, CS; Furer, T; Gao, Y; Garcia-Rivera, EJ; Gazdar, A; George, RB; Ghosh, S; Gianchecchi, E; Gleason, JM; Hackshaw, A; Hall, A; Hall, R; Harper, P; Hogg, WE; Huang, G; Hunter, KE; IJzerman, AP; Jesus, C; Jian, G; Lewis, JS; Kanj, SS; Kaur, H; Kelly, S; Kheir, F; Kichatova, VS; Kiyani, M; Klein, R; Kovesi, T; Kraschnewski, JL; Kumar, AP; Labutin, D; Lazo-Langner, A; Leclercq, G; Li, M; Li, Q; Li, T; Li, Y; Liao, W-T; Liao, Z-Y; Lin, J; Lizer, J; Lobreglio, G; Lowies, C; Lu, C; Majeed, H; Martin, A; Martinez-Sobrido, L; Meresh, E; Middelveen, M; Mohebbi, A; Mota, J; Mozaheb, Z; Muyaya, L; Nandhakumar, A; Ng, SHX; Obeidat, M; Oh, D-H; Owais, M; Pace-Asciak, P; Panwar, A; Park, C; Patterson, C; Penagos-Tabaree, F; Pianosi, PT; Pinzi, V; Pridans, C; Psaroulaki, A; Pujala, RK; Pulido-Arjona, L; Qi, P-F; Rahman, P; Rai, NK; Rassaf, T; Refardt, J; Ricciardi, W; Riess, O; Rovas, A; Sacks, FM; Saleh, S; Sampson, C; Schmutz, A; Sepanski, R; Sharma, N; Singh, M; Spearman, P; Subramaniapillai, M; Swali, R; Tan, CM; Tellechea, JI; Thomas, L-M; Tong, X; Veys, R; Vitriol, V; Wang, H-D; Wang, J; Wang, J; Waugh, J; Webb, SA; Williams, BA; Workman, AD; Xiang, T; Xie, L-X; Xu, J; Xu, T; Yang, C; Yoon, JG; Yuan, CM; Zaritsky, A; Zhang, Y; Zhao, H; Zuckerman, H; Lyu, R; Pullan, W; Zhou, Y (OXFORD UNIV PRESS, 2019-10-29)
    • Large Interobserver Variation in the International MR-LINAC Oropharyngeal Carcinoma Delineation Study 

      Blinde, S; Mohamed, ASR; Al-Mamgani, A; Newbold, K; Karam, I; Robbins, JR; Thomson, D; Fuller, CD; Raaijmakers, CP; Terhaard, C (ELSEVIER SCIENCE INC, 2017-10-01)
    • Large-scale Analysis Demonstrates Familial Testicular Cancer to have Polygenic Aetiology. 

      Loveday, C; Law, P; Litchfield, K; Levy, M; Holroyd, A; Broderick, P; Kote-Jarai, Z; Dunning, AM; Muir, K; Peto, J; Eeles, R; Easton, DF; Dudakia, D; Orr, N; Pashayan, N; UK Testicular Cancer Collaboration, The PRACTICAL Consortium; Reid, A; Huddart, RA; Houlston, RS; Turnbull, C (2018-09)
      Testicular germ cell tumour (TGCT) is the most common cancer in young men. Multiplex TGCT families have been well reported and analyses of population cancer registries have demonstrated a four- to eightfold risk to male ...
    • Large-scale genotyping identifies 41 new loci associated with breast cancer risk. 

      Michailidou, K; Hall, P; Gonzalez-Neira, A; Ghoussaini, M; Dennis, J; Milne, RL; Schmidt, MK; Chang-Claude, J; Bojesen, SE; Bolla, MK; Wang, Q; Dicks, E; Lee, A; Turnbull, C; Rahman, N; Breast and Ovarian Cancer Susceptibility Collaboration; Fletcher, O; Peto, J; Gibson, L; Dos Santos Silva, I; Nevanlinna, H; Muranen, TA; Aittomäki, K; Blomqvist, C; Czene, K; Irwanto, A; Liu, J; Waisfisz, Q; Meijers-Heijboer, H; Adank, M; Hereditary Breast and Ovarian Cancer Research Group Netherlands (HEBON); van der Luijt, RB; Hein, R; Dahmen, N; Beckman, L; Meindl, A; Schmutzler, RK; Müller-Myhsok, B; Lichtner, P; Hopper, JL; Southey, MC; Makalic, E; Schmidt, DF; Uitterlinden, AG; Hofman, A; Hunter, DJ; Chanock, SJ; Vincent, D; Bacot, F; Tessier, DC; Canisius, S; Wessels, LFA; Haiman, CA; Shah, M; Luben, R; Brown, J; Luccarini, C; Schoof, N; Humphreys, K; Li, J; Nordestgaard, BG; Nielsen, SF; Flyger, H; Couch, FJ; Wang, X; Vachon, C; Stevens, KN; Lambrechts, D; Moisse, M; Paridaens, R; Christiaens, M-R; Rudolph, A; Nickels, S; Flesch-Janys, D; Johnson, N; Aitken, Z; Aaltonen, K; Heikkinen, T; Broeks, A; Veer, LJV; van der Schoot, CE; Guénel, P; Truong, T; Laurent-Puig, P; Menegaux, F; Marme, F; Schneeweiss, A; Sohn, C; Burwinkel, B; Zamora, MP; Perez, JIA; Pita, G; Alonso, MR; Cox, A; Brock, IW; Cross, SS; Reed, MWR; Sawyer, EJ; Tomlinson, I; Kerin, MJ; Miller, N; Henderson, BE; Schumacher, F; Le Marchand, L; Andrulis, IL; Knight, JA; Glendon, G; Mulligan, AM; kConFab Investigators; Australian Ovarian Cancer Study Group; Lindblom, A; Margolin, S; Hooning, MJ; Hollestelle, A; van den Ouweland, AMW; Jager, A; Bui, QM; Stone, J; Dite, GS; Apicella, C; Tsimiklis, H; Giles, GG; Severi, G; Baglietto, L; Fasching, PA; Haeberle, L; Ekici, AB; Beckmann, MW; Brenner, H; Müller, H; Arndt, V; Stegmaier, C; Swerdlow, A; Ashworth, A; Orr, N; Jones, M; Figueroa, J; Lissowska, J; Brinton, L; Goldberg, MS; Labrèche, F; Dumont, M; Winqvist, R; Pylkäs, K; Jukkola-Vuorinen, A; Grip, M; Brauch, H; Hamann, U; Brüning, T; GENICA (Gene Environment Interaction and Breast Cancer in Germany) Network; Radice, P; Peterlongo, P; Manoukian, S; Bonanni, B; Devilee, P; Tollenaar, RAEM; Seynaeve, C; van Asperen, CJ; Jakubowska, A; Lubinski, J; Jaworska, K; Durda, K; Mannermaa, A; Kataja, V; Kosma, V-M; Hartikainen, JM; Bogdanova, NV; Antonenkova, NN; Dörk, T; Kristensen, VN; Anton-Culver, H; Slager, S; Toland, AE; Edge, S; Fostira, F; Kang, D; Yoo, K-Y; Noh, D-Y; Matsuo, K; Ito, H; Iwata, H; Sueta, A; Wu, AH; Tseng, C-C; Van Den Berg, D; Stram, DO; Shu, X-O; Lu, W; Gao, Y-T; Cai, H; Teo, SH; Yip, CH; Phuah, SY; Cornes, BK; Hartman, M; Miao, H; Lim, WY; Sng, J-H; Muir, K; Lophatananon, A; Stewart-Brown, S; Siriwanarangsan, P; Shen, C-Y; Hsiung, C-N; Wu, P-E; Ding, S-L; Sangrajrang, S; Gaborieau, V; Brennan, P; McKay, J; Blot, WJ; Signorello, LB; Cai, Q; Zheng, W; Deming-Halverson, S; Shrubsole, M; Long, J; Simard, J; Garcia-Closas, M; Pharoah, PDP; Chenevix-Trench, G; Dunning, AM; Benitez, J; Easton, DF (2013-04)
      Breast cancer is the most common cancer among women. Common variants at 27 loci have been identified as associated with susceptibility to breast cancer, and these account for ∼9% of the familial risk of the disease. We ...
    • Large-Scale Profiling of Kinase Dependencies in Cancer Cell Lines. 

      Campbell, J; Ryan, CJ; Brough, R; Bajrami, I; Pemberton, HN; Chong, IY; Costa-Cabral, S; Frankum, J; Gulati, A; Holme, H; Miller, R; Postel-Vinay, S; Rafiq, R; Wei, W; Williamson, CT; Quigley, DA; Tym, J; Al-Lazikani, B; Fenton, T; Natrajan, R; Strauss, SJ; Ashworth, A; Lord, CJ (2016-03-03)
      One approach to identifying cancer-specific vulnerabilities and therapeutic targets is to profile genetic dependencies in cancer cell lines. Here, we describe data from a series of siRNA screens that identify the kinase ...
    • Large-scale Sequencing of Testicular Germ Cell Tumour (TGCT) Cases Excludes Major TGCT Predisposition Gene. 

      Litchfield, K; Loveday, C; Levy, M; Dudakia, D; Rapley, E; Nsengimana, J; Bishop, DT; Reid, A; Huddart, R; Broderick, P; Houlston, RS; Turnbull, C (2018-06)
      Testicular germ cell tumour (TGCT), the most common cancer in young men, has a significant heritable basis that has long raised questions as to the existence of underlying major high-penetrance susceptibility gene(s). To ...
    • Large-scale transcriptome-wide association study identifies new prostate cancer risk regions. 

      Mancuso, N; Gayther, S; Gusev, A; Zheng, W; Penney, KL; Kote-Jarai, Z; Eeles, R; Freedman, M; Haiman, C; Pasaniuc, B; PRACTICAL consortium (2018-10-04)
      Although genome-wide association studies (GWAS) for prostate cancer (PrCa) have identified more than 100 risk regions, most of the risk genes at these regions remain largely unknown. Here we integrate the largest PrCa GWAS ...
    • Laryngeal cancer: United Kingdom National Multidisciplinary guidelines. 

      Jones, TM; De, M; Foran, B; Harrington, K; Mortimore, S (2016-05)
      This is the official guideline endorsed by the specialty associations involved in the care of head and neck cancer patients in the UK. Significantly new data have been published on laryngeal cancer management since the ...
    • Laser-free pelvic alignment in an online adaptive radiotherapy environment. 

      Barnes, H; Mohajer, J; Dunlop, A; Adair Smith, G; Herbert, T; Lawes, R; Tree, A; McNair, H (2020-03)
      The MR-Linac (MRL) provides a novel treatment modality that enables online adaptive treatments, but also creates new challenges for patient positioning in a laser-free environment. The accuracy and duration of prostate ...
    • Late normal tissue effects in the arm and shoulder following lymphatic radiotherapy: Results from the UK START (Standardisation of Breast Radiotherapy) trials. 

      Haviland, JS; Mannino, M; Griffin, C; Porta, N; Sydenham, M; Bliss, JM; Yarnold, JR; START Trialists' Group (2018-01)
      Adjuvant lymphatic radiotherapy (LNRT) is recommended for selected axillary node positive women with early breast cancer. We investigated whether hypofractionated LNRT is safe combined with similarly-hypofractionated ...
    • LAUNCH OF THE BREAST SCREENING AFTER RADIOTHERAPY DATASET - AN ENGLAND WIDE INITIATIVE TO IMPROVE SCREENING FOR BREAST CANCER IN 9,000 WOMEN AT HIGH RISK FOLLOWING RADIOTHERAPY TO BREAST TISSUE UNDER AGE 36 

      Radford, J; Howell, S; Vaughan, K; Goode, V; Worthington, D; Yates-Bolton, N; Payne, E; Jenkins, J; Sibbering, M; Swerdlow, A; Cowan, R (FERRATA STORTI FOUNDATION, 2016-10-01)
    • Lead-time in the European Randomised Study of Screening for Prostate Cancer 

      Finne, P; Fallah, M; Hakama, M; Ciatto, S; Hugosson, J; de Koning, H; Moss, S; Nelen, V; Auvinen, A (ELSEVIER SCI LTD, 2010-11)
      Background: Lead-time is defined as the time by which screening advances the diagnosis compared with absence of screening. A sufficiently long lead-time needs to be achieved so that cancer can be detected while still ...
    • Lenalidomide before and after ASCT for transplant-eligible patients of all ages in the randomized, phase III, Myeloma XI trial. 

      Jackson, GH; Davies, FE; Pawlyn, C; Cairns, DA; Striha, A; Collett, C; Waterhouse, A; Jones, JR; Kishore, B; Garg, M; Williams, CD; Karunanithi, K; Lindsay, J; Allotey, D; Shafeek, S; Jenner, MW; Cook, G; Russell, NH; Kaiser, MF; Drayson, MT; Owen, RG; Gregory, WM; Morgan, GJ; UK NCRI Haematological Oncology Clinical Studies Group (2020-06-04)
      The optimal way to use immunomodulatory drugs as components of induction and maintenance therapy for multiple myeloma is unresolved. We addressed this question in a large phase III randomized trial, Myeloma XI. Patients ...
    • Lenalidomide maintenance versus observation for patients with newly diagnosed multiple myeloma (Myeloma XI): a multicentre, open-label, randomised, phase 3 trial. 

      Jackson, GH; Davies, FE; Pawlyn, C; Cairns, DA; Striha, A; Collett, C; Hockaday, A; Jones, JR; Kishore, B; Garg, M; Williams, CD; Karunanithi, K; Lindsay, J; Jenner, MW; Cook, G; Russell, NH; Kaiser, MF; Drayson, MT; Owen, RG; Gregory, WM; Morgan, GJ; UK NCRI Haemato-oncology Clinical Studies Group (2019-01)
      BACKGROUND:Patients with multiple myeloma treated with lenalidomide maintenance therapy have improved progression-free survival, primarily following autologous stem-cell transplantation. A beneficial effect of lenalidomide ...
    • Lenalidomide, dexamethasone and alemtuzumab or ofatumumab in high-risk chronic lymphocytic leukaemia: final results of the NCRI CLL210 trial. 

      Pettitt, AR; Jackson, R; Cicconi, S; Polydoros, F; Yap, C; Dodd, J; Bickerstaff, M; Stackpoole, M; Khan, UT; Carruthers, S; Oates, M; Lin, K; Coupland, SE; Menon, G; Kalakonda, N; McCarthy, H; Bloor, A; Schuh, A; Duncombe, A; Dearden, C; Fegan, C; Kennedy, B; Walewska, R; Marshall, S; Fox, CP; Hillmen, P (2020-02-13)
    • Length of FMR1 repeat alleles within the normal range does not substantially affect the risk of early menopause. 

      Ruth, KS; Bennett, CE; Schoemaker, MJ; Weedon, MN; Swerdlow, AJ; Murray, A (2016-10)
      Is the length of FMR1 repeat alleles within the normal range associated with the risk of early menopause?The length of repeat alleles within the normal range does not substantially affect risk of early menopause.There is ...