Now showing items 2198-2217 of 3129

    • Polygenic hazard score to guide screening for aggressive prostate cancer: development and validation in large scale cohorts. 

      Seibert, TM; Fan, CC; Wang, Y; Zuber, V; Karunamuni, R; Parsons, JK; Eeles, RA; Easton, DF; Kote-Jarai, Z; Al Olama, AA; Garcia, SB; Muir, K; Grönberg, H; Wiklund, F; Aly, M; Schleutker, J; Sipeky, C; Tammela, TL; Nordestgaard, BG; Nielsen, SF; Weischer, M; Bisbjerg, R; Røder, MA; Iversen, P; Key, TJ; Travis, RC; Neal, DE; Donovan, JL; Hamdy, FC; Pharoah, P; Pashayan, N; Khaw, K-T; Maier, C; Vogel, W; Luedeke, M; Herkommer, K; Kibel, AS; Cybulski, C; Wokolorczyk, D; Kluzniak, W; Cannon-Albright, L; Brenner, H; Cuk, K; Saum, K-U; Park, JY; Sellers, TA; Slavov, C; Kaneva, R; Mitev, V; Batra, J; Clements, JA; Spurdle, A; Teixeira, MR; Paulo, P; Maia, S; Pandha, H; Michael, A; Kierzek, A; Karow, DS; Mills, IG; Andreassen, OA; Dale, AM; PRACTICAL Consortium* (2018-01-10)
      OBJECTIVES: To develop and validate a genetic tool to predict age of onset of aggressive prostate cancer (PCa) and to guide decisions of who to screen and at what age. DESIGN: Analysis of genotype, PCa status, and age to ...
    • Polygenic Risk Scores for Prediction of Breast Cancer and Breast Cancer Subtypes. 

      Mavaddat, N; Michailidou, K; Dennis, J; Lush, M; Fachal, L; Lee, A; Tyrer, JP; Chen, T-H; Wang, Q; Bolla, MK; Yang, X; Adank, MA; Ahearn, T; Aittomäki, K; Allen, J; Andrulis, IL; Anton-Culver, H; Antonenkova, NN; Arndt, V; Aronson, KJ; Auer, PL; Auvinen, P; Barrdahl, M; Beane Freeman, LE; Beckmann, MW; Behrens, S; Benitez, J; Bermisheva, M; Bernstein, L; Blomqvist, C; Bogdanova, NV; Bojesen, SE; Bonanni, B; Børresen-Dale, A-L; Brauch, H; Bremer, M; Brenner, H; Brentnall, A; Brock, IW; Brooks-Wilson, A; Brucker, SY; Brüning, T; Burwinkel, B; Campa, D; Carter, BD; Castelao, JE; Chanock, SJ; Chlebowski, R; Christiansen, H; Clarke, CL; Collée, JM; Cordina-Duverger, E; Cornelissen, S; Couch, FJ; Cox, A; Cross, SS; Czene, K; Daly, MB; Devilee, P; Dörk, T; Dos-Santos-Silva, I; Dumont, M; Durcan, L; Dwek, M; Eccles, DM; Ekici, AB; Eliassen, AH; Ellberg, C; Engel, C; Eriksson, M; Evans, DG; Fasching, PA; Figueroa, J; Fletcher, O; Flyger, H; Försti, A; Fritschi, L; Gabrielson, M; Gago-Dominguez, M; Gapstur, SM; García-Sáenz, JA; Gaudet, MM; Georgoulias, V; Giles, GG; Gilyazova, IR; Glendon, G; Goldberg, MS; Goldgar, DE; González-Neira, A; Grenaker Alnæs, GI; Grip, M; Gronwald, J; Grundy, A; Guénel, P; Haeberle, L; Hahnen, E; Haiman, CA; Håkansson, N; Hamann, U; Hankinson, SE; Harkness, EF; Hart, SN; He, W; Hein, A; Heyworth, J; Hillemanns, P; Hollestelle, A; Hooning, MJ; Hoover, RN; Hopper, JL; Howell, A; Huang, G; Humphreys, K; Hunter, DJ; Jakimovska, M; Jakubowska, A; Janni, W; John, EM; Johnson, N; Jones, ME; Jukkola-Vuorinen, A; Jung, A; Kaaks, R; Kaczmarek, K; Kataja, V; Keeman, R; Kerin, MJ; Khusnutdinova, E; Kiiski, JI; Knight, JA; Ko, Y-D; Kosma, V-M; Koutros, S; Kristensen, VN; Krüger, U; Kühl, T; Lambrechts, D; Le Marchand, L; Lee, E; Lejbkowicz, F; Lilyquist, J; Lindblom, A; Lindström, S; Lissowska, J; Lo, W-Y; Loibl, S; Long, J; Lubiński, J; Lux, MP; MacInnis, RJ; Maishman, T; Makalic, E; Maleva Kostovska, I; Mannermaa, A; Manoukian, S; Margolin, S; Martens, JWM; Martinez, ME; Mavroudis, D; McLean, C; Meindl, A; Menon, U; Middha, P; Miller, N; Moreno, F; Mulligan, AM; Mulot, C; Muñoz-Garzon, VM; Neuhausen, SL; Nevanlinna, H; Neven, P; Newman, WG; Nielsen, SF; Nordestgaard, BG; Norman, A; Offit, K; Olson, JE; Olsson, H; Orr, N; Pankratz, VS; Park-Simon, T-W; Perez, JIA; Pérez-Barrios, C; Peterlongo, P; Peto, J; Pinchev, M; Plaseska-Karanfilska, D; Polley, EC; Prentice, R; Presneau, N; Prokofyeva, D; Purrington, K; Pylkäs, K; Rack, B; Radice, P; Rau-Murthy, R; Rennert, G; Rennert, HS; Rhenius, V; Robson, M; Romero, A; Ruddy, KJ; Ruebner, M; Saloustros, E; Sandler, DP; Sawyer, EJ; Schmidt, DF; Schmutzler, RK; Schneeweiss, A; Schoemaker, MJ; Schumacher, F; Schürmann, P; Schwentner, L; Scott, C; Scott, RJ; Seynaeve, C; Shah, M; Sherman, ME; Shrubsole, MJ; Shu, X-O; Slager, S; Smeets, A; Sohn, C; Soucy, P; Southey, MC; Spinelli, JJ; Stegmaier, C; Stone, J; Swerdlow, AJ; Tamimi, RM; Tapper, WJ; Taylor, JA; Terry, MB; Thöne, K; Tollenaar, RAEM; Tomlinson, I; Truong, T; Tzardi, M; Ulmer, H-U; Untch, M; Vachon, CM; van Veen, EM; Vijai, J; Weinberg, CR; Wendt, C; Whittemore, AS; Wildiers, H; Willett, W; Winqvist, R; Wolk, A; Yang, XR; Yannoukakos, D; Zhang, Y; Zheng, W; Ziogas, A; ABCTB Investigators; kConFab/AOCS Investigators; NBCS Collaborators; Dunning, AM; Thompson, DJ; Chenevix-Trench, G; Chang-Claude, J; Schmidt, MK; Hall, P; Milne, RL; Pharoah, PDP; Antoniou, AC; Chatterjee, N; Kraft, P; García-Closas, M; Simard, J; Easton, DF (2019-01-03)
      Stratification of women according to their risk of breast cancer based on polygenic risk scores (PRSs) could improve screening and prevention strategies. Our aim was to develop PRSs, optimized for prediction of estrogen ...
    • Polymer-assisted solution-phase library synthesis of 4-alkoxy-2-hydroxy-3,5,6-trifluorobenzoic acids 

      Hardcastle, IR; Barber, AM; Marriott, JH; Jarman, M (2001)
      The efficient synthesis of a small library of 4-alkoxy-2-hydroxy-3,5,6-trifluorobenzoic acids is described via the fluoride mediated alkylation of 5,6,8-trifluoro-7-hydroxy-2-methyl-benzo[1,3]dioxin-4-one with a collection ...
    • Polymorphisms of DNA repair genes and risk of non-small cell lung cancer 

      Zienolddiny, S; Campa, D; Lind, H; Ryberg, D; Skaug, V; Stangeland, L; Phillips, DH; Canzian, F; Haugen, A (OXFORD UNIV PRESS, 2006-03)
      Lung cancer is a leading cause of cancer mortality with an inter-individual difference in susceptibility to the disease. The inheritance of low-efficiency genotypes involved in DNA repair and replication may contribute to ...
    • Polypharmacology in Precision Oncology: Current Applications and Future Prospects. 

      Antolin, AA; Workman, P; Mestres, J; Al-Lazikani, B (2016-09-23)
      Over the past decade, a more comprehensive, large-scale approach to studying cancer genetics and biology has revealed the challenges of tumor heterogeneity, adaption, evolution and drug resistance, while systems-based ...
    • Polyunsaturated fatty acids and prostate cancer risk: a Mendelian randomisation analysis from the PRACTICAL consortium. 

      Khankari, NK; Murff, HJ; Zeng, C; Wen, W; Eeles, RA; Easton, DF; Kote-Jarai, Z; Al Olama, AA; Benlloch, S; Muir, K; Giles, GG; Wiklund, F; Gronberg, H; Haiman, CA; Schleutker, J; Nordestgaard, BG; Travis, RC; Donovan, JL; Pashayan, N; Khaw, KT; Stanford, JL; Blot, WJ; Thibodeau, SN; Maier, C; Kibel, AS; Cybulski, C; Cannon-Albright, L; Brenner, H; Park, J; Kaneva, R; Batra, J; Teixeira, MR; Pandha, H; Zheng, W (2016-08-04)
      Prostate cancer is a common cancer worldwide with no established modifiable lifestyle factors to guide prevention. The associations between polyunsaturated fatty acids (PUFAs) and prostate cancer risk have been inconsistent. ...
    • Pooled Systemic Efficacy and Safety Data from the Pivotal Phase II Studies (NP28673 and NP28761) of Alectinib in ALK-positive Non-Small Cell Lung Cancer. 

      Yang, JC-H; Ou, S-HI; De Petris, L; Gadgeel, S; Gandhi, L; Kim, D-W; Barlesi, F; Govindan, R; Dingemans, A-MC; Crino, L; Lena, H; Popat, S; Ahn, JS; Dansin, E; Golding, S; Bordogna, W; Balas, B; Morcos, PN; Zeaiter, A; Shaw, AT (2017-10)
      INTRODUCTION: Alectinib demonstrated clinical efficacy and an acceptable safety profile in two phase II studies (NP28761 and NP28673). Here we report the pooled efficacy and safety data after 15 and 18 months more follow-up ...
    • A pooling project of studies participating in the National Cancer Institute Cohort Consortium. 

      Swerdlow, A; schoemaker, M; wright, LB; brook, MN; jones, ME
    • Poor treatment outcomes with palliative gemcitabine and docetaxel chemotherapy in advanced and metastatic synovial sarcoma. 

      Pender, A; Davis, EJ; Chauhan, D; Messiou, C; Al-Muderis, O; Thway, K; Fisher, C; Zaidi, S; Miah, A; Judson, I; van der Graaf, W; Keedy, VL; Benson, C; Jones, RL (2018-08-20)
      The outcome for patients with unresectable or metastatic soft tissue sarcoma remains poor with few treatment options. Synovial sarcoma is a rare type of sarcoma, predominantly affecting adolescents and young adults. Following ...
    • Population screening for colorectal cancer: the implications of an ageing population 

      Macafee, DAL; Waller, M; Whynes, DK; Moss, S; Scholefield, JH (NATURE PUBLISHING GROUP, 2008-12-09)
      Population screening for colorectal cancer (CRC) has recently commenced in the United Kingdom supported by the evidence of a number of randomised trials and pilot studies. Certain factors are known to influence screening ...
    • The positive experience of screening quality among users of a cervical cancer detection center 

      Lazcano-Ponce, EC; Moss, S; Cruz-Valdez, A; de Ruiz, PA; Martinez-Leon, CJ; Casares-Queralt, S; Hernandez-Avila, M
      Background. Our objective was to determine the main factors associated with increased utilization of a cervical cancer screening program (CCSP) in a population with a high mortality rate due to cervical cancer. Methods. A ...
    • Positive selection of a gene family during the emergence of humans and African apes 

      Johnson, ME; Viggiano, L; Bailey, JA; Abdul-Rauf, M; Goodwin, G; Rocchi, M; Eichler, EE (NATURE PUBLISHING GROUP, 2001-10-04)
      Gene duplication followed by adaptive evolution is one of the primary forces for the emergence of new gene function(1). Here we describe the recent proliferation, transposition and selection of a 20-kilobase (kb) duplicated ...
    • Positive Selection of Tyrosine Loss in Metazoan Evolution 

      Tan, CSH; Pasculescu, A; Lim, WA; Pawson, T; Bader, GD; Linding, R (AMER ASSOC ADVANCEMENT SCIENCE, 2009-09-25)
      John Nash showed that within a complex system, individuals are best off if they make the best decision that they can, taking into account the decisions of the other individuals. Here, we investigate whether similar principles ...
    • Positron Emission Tomography/Computed Tomography Assessment After Immunochemotherapy and Irradiation Using the Lugano Classification Criteria in the IELSG-26 Study of Primary Mediastinal B-Cell Lymphoma. 

      Ceriani, L; Martelli, M; Gospodarowicz, MK; Ricardi, U; Ferreri, AJM; Chiappella, A; Stelitano, C; Balzarotti, M; Cabrera, ME; Cunningham, D; Guarini, A; Zinzani, PL; Giovanella, L; Johnson, PWM; Zucca, E (2017-01-01)
      PURPOSE: To assess the predictive value of 18F-fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) for disease recurrence after immunochemotherapy (R-CHT) and mediastinal irradiation (RT), using ...
    • Positron Emission Tomography/Computed Tomography with 89Zr-girentuximab Can Aid in Diagnostic Dilemmas of Clear Cell Renal Cell Carcinoma Suspicion. 

      Hekman, MCH; Rijpkema, M; Aarntzen, EH; Mulder, SF; Langenhuijsen, JF; Oosterwijk, E; Boerman, OC; Oyen, WJG; Mulders, PFA (2018-09)
      Based on the high expression of carbonic anhydrase IX (CAIX) in 95% of clear cell renal cell carcinoma (ccRCC), the anti-CAIX monoclonal antibody girentuximab can be used for the detection of ccRCC. This clinical study ...
    • Possible role of pandemic AH1N1 swine flu virus in a childhood leukemia cluster 

      Cazzaniga, G; Bisanti, L; Randi, G; Deandrea, S; Bungaro, S; Pregliasco, F; Perotti, D; Spreafico, F; Masera, G; Valsecchi, MG; Biondi, A; Greaves, M (Springer Science and Business Media LLC, 2017-08)
    • Post hoc Analysis for Detecting Individual Rare Variant Risk Associations Using Probit Regression Bayesian Variable Selection Methods in Case-Control Sequencing Studies. 

      Larson, NB; McDonnell, S; Albright, LC; Teerlink, C; Stanford, J; Ostrander, EA; Isaacs, WB; Xu, J; Cooney, KA; Lange, E; Schleutker, J; Carpten, JD; Powell, I; Bailey-Wilson, J; Cussenot, O; Cancel-Tassin, G; Giles, G; MacInnis, R; Maier, C; Whittemore, AS; Hsieh, CL; Wiklund, F; Catolona, WJ; Foulkes, W; Mandal, D; Eeles, R; Kote-Jarai, Z; Ackerman, MJ; Olson, TM; Klein, CJ; Thibodeau, SN; Schaid, DJ (2016-09)
      Rare variants (RVs) have been shown to be significant contributors to complex disease risk. By definition, these variants have very low minor allele frequencies and traditional single-marker methods for statistical analysis ...
    • Post-herpetic neuralgia – a review of current management and future directions 

      Schutzer-Weissmann, J; Farquhar-Smith, P (Informa UK Limited, 2017-11-02)
    • Post-relapse outcomes after primary extended resection of retroperitoneal sarcoma: A report from the Trans-Atlantic RPS Working Group. 

      MacNeill, AJ; Miceli, R; Strauss, DC; Bonvalot, S; Hohenberger, P; Van Coevorden, F; Rutkowski, P; Callegaro, D; Hayes, AJ; Honoré, C; Fairweather, M; Cannell, A; Jakob, J; Haas, RL; Szacht, M; Fiore, M; Casali, PG; Pollock, RE; Raut, CP; Gronchi, A; Swallow, CJ (2017-06-01)
      BACKGROUND: Despite a radical surgical approach to primary retroperitoneal sarcoma (RPS), many patients experience locoregional and/or distant recurrence. The objective of this study was to analyze post-relapse outcomes ...
    • Post-Transplantation Cyclophosphamide-Based Haploidentical Transplantation as Alternative to Matched Sibling or Unrelated Donor Transplantation for Hodgkin Lymphoma: A Registry Study of the Lymphoma Working Party of the European Society for Blood and Marrow Transplantation. 

      Martínez, C; Gayoso, J; Canals, C; Finel, H; Peggs, K; Dominietto, A; Castagna, L; Afanasyev, B; Robinson, S; Blaise, D; Corradini, P; Itälä-Remes, M; Bermúdez, A; Forcade, E; Russo, D; Potter, M; McQuaker, G; Yakoub-Agha, I; Scheid, C; Bloor, A; Montoto, S; Dreger, P; Sureda, A; Lymphoma Working Party of the European Group for Blood and Marrow Transplantation (2017-10-20)
      Purpose To compare the outcome of patients with Hodgkin lymphoma who received post-transplantation cyclophosphamide-based haploidentical (HAPLO) allogeneic hematopoietic cell transplantation with the outcome of patients ...