Now showing items 2560-2579 of 3378

    • Quality of treatment plans and accuracy of in vivo portal dosimetry in hybrid intensity-modulated radiation therapy and volumetric modulated arc therapy for prostate cancer. 

      Bedford, JL; Smyth, G; Hanson, IM; Tree, AC; Dearnaley, DP; Hansen, VN (2016-08)
      Delivering selected parts of volumetric modulated arc therapy (VMAT) plans using step-and-shoot intensity modulated radiotherapy (IMRT) beams has the potential to increase plan quality by allowing specific aperture ...
    • The Quality Sequencing Minimum (QSM): providing comprehensive, consistent, transparent next generation sequencing  data quality assurance. 

      Mahamdallie, S; Ruark, E; Yost, S; Münz, M; Renwick, A; Poyastro-Pearson, E; Strydom, A; Seal, S; Rahman, N (2018-01)
      Next generation sequencing (NGS) is routinely used in clinical genetic testing. Quality management of NGS testing is essential to ensure performance is consistently and rigorously evaluated. Three primary metrics are used ...
    • Quantifiable mRNA transcripts for tamoxifen-metabolising enzymes in human endometrium 

      Singh, MN; Stringfellow, HF; Walsh, MJ; Ashton, KM; Paraskevaidis, E; Abdo, KR; Martin-Hirsch, PL; Phillips, DH; Martin, FL (ELSEVIER IRELAND LTD, 2008-07-10)
      Tamoxifen has been used in the management of receptor-positive breast cancer for >20 years. Usage confers an elevated risk of developing endometrial carcinoma. Its mechanism of carcinogenicity remains unresolved with ...
    • Quantification of subclonal selection in cancer from bulk sequencing data. 

      Williams, MJ; Werner, B; Heide, T; Curtis, C; Barnes, CP; Sottoriva, A; Graham, TA (2018-06)
      Subclonal architectures are prevalent across cancer types. However, the temporal evolutionary dynamics that produce tumor subclones remain unknown. Here we measure clone dynamics in human cancers by using computational ...
    • Quantifying effects of lead shielding in electron beams: a Monte Carlo study 

      Verhaegen, F; Buffa, FM; Deehan, C (IOP PUBLISHING LTD, 2001-03)
      Lead shielding in contact with the patient’s skin is often encountered in radiotherapy with electron beams. The influence of the lead shielding on dose distributions in the patient cannot fully be assessed using modern ...
    • Quantifying sclerotic bone metastases with 2D ultra short TE MRI: a feasibility study. 

      Messiou, C; Collins, DJ; Morgan, VA; Robson, MD; deBono, JS; Bydder, GM; deSouza, NM (2010-01)
      INTRODUCTION: Ultra Short TE MRI allows signal to be detected from tissues with a very short T2.The aims of this study were to optimize a 2D UTE MRI sequence for imaging and quantification of sclerotic bone metastases, ...
    • Quantifying the Genetic Correlation between Multiple Cancer Types. 

      Lindström, S; Finucane, H; Bulik-Sullivan, B; Schumacher, FR; Amos, CI; Hung, RJ; Rand, K; Gruber, SB; Conti, D; Permuth, JB; Lin, H-Y; Goode, EL; Sellers, TA; Amundadottir, LT; Stolzenberg-Solomon, R; Klein, A; Petersen, G; Risch, H; Wolpin, B; Hsu, L; Huyghe, JR; Chang-Claude, J; Chan, A; Berndt, S; Eeles, R; Easton, D; Haiman, CA; Hunter, DJ; Neale, B; Price, AL; Kraft, P; PanScan, GECCO and the GAME-ON Network: CORECT, DRIVE, ELLIPSE, FOCI, and TRICL-ILCCO (2017-09)
      Background: Many cancers share specific genetic risk factors, including both rare high-penetrance mutations and common SNPs identified through genome-wide association studies (GWAS). However, little is known about the ...
    • Quantitative actin folding reactions using yeast CCT purified via an internal tag in the CCT3/gamma subunit 

      Pappenberger, G; McCormack, EA; Willison, KR (ACADEMIC PRESS LTD ELSEVIER SCIENCE LTD, 2006-07-07)
      The eukaryotic cytosolic chaperonin CCT is an essential ATP-dependent protein folding machine whose action is required for folding the cytoskeletal proteins actin and tubulin, and a small number of other substrates, including ...
    • Quantitative Brain MRI in Congenital Adrenal Hyperplasia: In Vivo Assessment of the Cognitive and Structural Impact of Steroid Hormones. 

      Webb, EA; Elliott, L; Carlin, D; Wilson, M; Hall, K; Netherton, J; Reed, J; Barrett, TG; Salwani, V; Clayden, JD; Arlt, W; Krone, N; Peet, AC; Wood, AG (2018-04)
      Context:Brain white matter hyperintensities are seen on routine clinical imaging in 46% of adults with congenital adrenal hyperplasia (CAH). The extent and functional relevance of these abnormalities have not been studied ...
    • Quantitative evaluation of contrast agent uptake in standard fat-suppressed dynamic contrast-enhanced MRI examinations of the breast. 

      Kousi, E; Smith, J; Ledger, AE; Scurr, E; Allen, S; Wilson, RM; O'Flynn, E; Pope, RJE; Leach, MO; Schmidt, MA (2018-01)
      To propose a method to quantify T1 and contrast agent uptake in breast dynamic contrast-enhanced (DCE) examinations undertaken with standard clinical fat-suppressed MRI sequences and to demonstrate the proposed approach ...
    • Quantitative phosphoproteomic analysis of acquired cancer drug resistance to pazopanib and dasatinib. 

      Vyse, S; McCarthy, F; Broncel, M; Paul, A; Wong, JP; Bhamra, A; Huang, PH (2018-01)
      Acquired drug resistance impacts the majority of patients being treated with tyrosine kinase inhibitors (TKIs) and remains a key challenge in modern anti-cancer therapy. The lack of clinically effective therapies to overcome ...
    • Quantitative photoacoustic imaging study of tumours in vivo: Baseline variations in quantitative measurements. 

      Martinho Costa, M; Shah, A; Rivens, I; Box, C; O'Shea, T; Papaevangelou, E; Bamber, J; Ter Haar, G (2019-03)
      Photoacoustic imaging (PAI) provides information on haemoglobin levels and blood oxygenation (sO2). To facilitate assessment of the variability in sO2 and haemoglobin in tumours, for example in response to therapies, the ...
    • R-IDEAL: A Framework for Systematic Clinical Evaluation of Technical Innovations in Radiation Oncology. 

      Verkooijen, HM; Kerkmeijer, LGW; Fuller, CD; Huddart, R; Faivre-Finn, C; Verheij, M; Mook, S; Sahgal, A; Hall, E; Schultz, C (2017-01)
      The pace of innovation in radiation oncology is high and the window of opportunity for evaluation narrow. Financial incentives, industry pressure, and patients' demand for high-tech treatments have led to widespread ...
    • Rabbit endogenous retrovirus-H encodes a functional protease 

      Voisset, C; Myers, RE; Carne, A; Kellam, P; Griffiths, DJ (2003-01)
      Recent studies have revealed that ‘human retrovirus-5’ sequences found in human samples belong to a rabbit endogenous retrovirus family named RERV-H. A part of the gag-pro region of the RERV-H genome was amplified by PCR ...
    • RAD51B in Familial Breast Cancer. 

      Pelttari, LM; Khan, S; Vuorela, M; Kiiski, JI; Vilske, S; Nevanlinna, V; Ranta, S; Schleutker, J; Winqvist, R; Kallioniemi, A; Dörk, T; Bogdanova, NV; Figueroa, J; Pharoah, PDP; Schmidt, MK; Dunning, AM; García-Closas, M; Bolla, MK; Dennis, J; Michailidou, K; Wang, Q; Hopper, JL; Southey, MC; Rosenberg, EH; Fasching, PA; Beckmann, MW; Peto, J; Dos-Santos-Silva, I; Sawyer, EJ; Tomlinson, I; Burwinkel, B; Surowy, H; Guénel, P; Truong, T; Bojesen, SE; Nordestgaard, BG; Benitez, J; González-Neira, A; Neuhausen, SL; Anton-Culver, H; Brenner, H; Arndt, V; Meindl, A; Schmutzler, RK; Brauch, H; Brüning, T; Lindblom, A; Margolin, S; Mannermaa, A; Hartikainen, JM; Chenevix-Trench, G; kConFab/AOCS Investigators; Van Dyck, L; Janssen, H; Chang-Claude, J; Rudolph, A; Radice, P; Peterlongo, P; Hallberg, E; Olson, JE; Giles, GG; Milne, RL; Haiman, CA; Schumacher, F; Simard, J; Dumont, M; Kristensen, V; Borresen-Dale, A-L; Zheng, W; Beeghly-Fadiel, A; Grip, M; Andrulis, IL; Glendon, G; Devilee, P; Seynaeve, C; Hooning, MJ; Collée, M; Cox, A; Cross, SS; Shah, M; Luben, RN; Hamann, U; Torres, D; Jakubowska, A; Lubinski, J; Couch, FJ; Yannoukakos, D; Orr, N; Swerdlow, A; Darabi, H; Li, J; Czene, K; Hall, P; Easton, DF; Mattson, J; Blomqvist, C; Aittomäki, K; Nevanlinna, H (2016-01)
      Common variation on 14q24.1, close to RAD51B, has been associated with breast cancer: rs999737 and rs2588809 with the risk of female breast cancer and rs1314913 with the risk of male breast cancer. The aim of this study ...
    • Radiation induced angiosarcoma of the breast: outcomes from a retrospective case series. 

      Cohen-Hallaleh, RB; Smith, HG; Smith, RC; Stamp, GF; Al-Muderis, O; Thway, K; Miah, A; Khabra, K; Judson, I; Jones, R; Benson, C; Hayes, AJ (2017-01)
      Radiation induced angiosarcoma (RIAS) of the breast is a rare and aggressive complication of radiotherapy. Due to the rarity of this disease, much of the evidence for its management is based on case reports or small ...
    • Radiation response and cure rate of human colon adenocarcinoma spheroids of different size: the significance of hypoxia on tumor control modelling 

      Buffa, FM; West, C; Byrne, K; Moore, JV; Nahum, AE (2001)
      Purpose: To evaluate the adequacy of a Poisson tumor control probability (tcp) model and the impact of hypoxia on tumor cure. Methods and Materials: A human colon adenocarcinoma cell line, WiDr, was grown as multicellular ...
    • Radiation Safety Culture in the UK Medical Sector: A Top to Bottom Strategy. 

      Chapple, C-L; Bradley, A; Murray, M; Orr, P; Reay, J; Riley, P; Rogers, A; Sandhu, N; Thurston, J (2017-04)
      UK professional bodies have established a number of sectorial working parties to provide guidance on the improvement of radiation safety (RS) culture in the workplace. The medical sector provides unique challenges in this ...
    • Radiation-induced hypopituitarism 

      Fernandez, A; Brada, M; Zabuliene, L; Karavitaki, N; Wass, JAH (BIOSCIENTIFICA LTD, 2009-09)
      The hypothalamic-pituitary unit is a particularly radiosensitive region in the central nervous system. As a consequence, hypopituitarism commonly develops after radiation treatments for sellar and parasellar neoplasms, ...
    • A radiobiological model of metastatic burden reduction for molecular radiotherapy: application to patients with bone metastases. 

      Denis-Bacelar, AM; Chittenden, SJ; Murray, I; Divoli, A; Ralph McCready, V; Dearnaley, DP; O'Sullivan, JM; Johnson, B; Flux, GD (2017-04)
      Skeletal tumour burden is a biomarker of prognosis and survival in cancer patients. This study proposes a novel method based on the linear quadratic model to predict the reduction in metastatic tumour burden as a function ...