Now showing items 2860-2879 of 3035

    • Towards ultrasound-guided adaptive radiotherapy for cervical cancer: Evaluation of Elekta's semiautomated uterine segmentation method on 3D ultrasound images. 

      Mason, SA; O'Shea, TP; White, IM; Lalondrelle, S; Downey, K; Baker, M; Behrens, CF; Bamber, JC; Harris, EJ (2017-07)
      PURPOSE: 3D ultrasound (US) images of the uterus may be used to adapt radiotherapy (RT) for cervical cancer patients based on changes in daily anatomy. This requires accurate on-line segmentation of the uterus. The aim of ...
    • Toxicity and Efficacy of >= 4th Line Palbociclib with Endocrine Therapy of Physician's Choice: a Single Centre Experience 

      Kingston, B; Charbouni, N; Doody, C; Irfan, T; Okines, A; Johnston, S (2017-06)
    • Toxicity and Patient-Reported Outcomes of a Phase 2 Randomized Trial of Prostate and Pelvic Lymph Node Versus Prostate only Radiotherapy in Advanced Localised Prostate Cancer (PIVOTAL). 

      Dearnaley, D; Griffin, CL; Lewis, R; Mayles, P; Mayles, H; Naismith, OF; Harris, V; Scrase, CD; Staffurth, J; Syndikus, I; Zarkar, A; Ford, DR; Rimmer, YL; Horan, G; Khoo, V; Frew, J; Venkitaraman, R; Hall, E (2019-03-01)
      PURPOSE: To establish the toxicity profile of high-dose pelvic lymph node intensity-modulated radiation therapy (IMRT) and to assess whether it is safely deliverable at multiple centers. METHODS AND MATERIALS: In this phase ...
    • Toxicity and Survival Outcomes of a Randomized Phase 2 Trial of Hypofractionated Bladder Radiation Therapy in an Elderly Population With or Without Image Guided Adaptive Plan Selection (HYBRID - CRUK/12/055) 

      Huddart, RA; Henry, A; Khoo, V; Staffurth, J; Syndikus, I; Hansen, V; McNair, H; Hafeez, S; Lewis, R; Parsons, E; Baker, A; Vassallo-Bonner, C; Moinuddin, S; Illambas, J; Birtle, A; Horan, G; Rimmer, Y; Venkitaraman, R; Mitra, A; Hall, E (2017-10-01)
    • TP53 Mutational Status Is a Potential Marker for Risk Stratification in Wilms Tumour with Diffuse Anaplasia 

      Popov, Sergey (2014-10)
      Purpose: The presence of diffuse anaplasia in Wilms tumours (DAWT) is associated with TP53 mutations and poor outcome. As patients receive intensified treatment, we sought to identify whether TP53 mutational status confers ...
    • TPL-2-Mediated Activation of MAPK Downstream of TLR4 Signaling Is Coupled to Arginine Availability 

      Mieulet, V; Yan, L; Choisy, C; Sully, K; Procter, J; Kouroumalis, A; Krywawych, S; Pende, M; Ley, SC; Moinard, C; Lamb, RF (AMER ASSOC ADVANCEMENT SCIENCE, 2010-08-17)
      The innate immune response is influenced by the nutrient status of the host. Mitogen-activated protein kinases (MAPKs), such as extracellular signal-regulated kinase 1 (ERK1) and ERK2, are activated after the stimulation ...
    • TPOAb and Thyroid Function Are Not Associated with Breast Cancer Outcome: Evidence from a Large-Scale Study Using Data from the Taxotere as Adjuvant Chemotherapy Trial (TACT, CRUK01/001). 

      Muller, I; Kilburn, LS; Taylor, PN; Barrett-Lee, PJ; Bliss, JM; Ellis, P; Ludgate, ME; Dayan, CM (2017-07)
      BACKGROUND: Small-scale studies correlated the presence of thyroid autoimmunity with both improved or worsened breast cancer outcome. OBJECTIVES: We aimed to clarify this association in a large cohort using the phase III, ...
    • Tracking Cancer Evolution Reveals Constrained Routes to Metastases: TRACERx Renal. 

      Turajlic, S; Xu, H; Litchfield, K; Rowan, A; Chambers, T; Lopez, JI; Nicol, D; O'Brien, T; Larkin, J; Horswell, S; Stares, M; Au, L; Jamal-Hanjani, M; Challacombe, B; Chandra, A; Hazell, S; Eichler-Jonsson, C; Soultati, A; Chowdhury, S; Rudman, S; Lynch, J; Fernando, A; Stamp, G; Nye, E; Jabbar, F; Spain, L; Lall, S; Guarch, R; Falzon, M; Proctor, I; Pickering, L; Gore, M; Watkins, TBK; Ward, S; Stewart, A; DiNatale, R; Becerra, MF; Reznik, E; Hsieh, JJ; Richmond, TA; Mayhew, GF; Hill, SM; McNally, CD; Jones, C; Rosenbaum, H; Stanislaw, S; Burgess, DL; Alexander, NR; Swanton, C; PEACE; TRACERx Renal Consortium (2018-04-19)
      Clear-cell renal cell carcinoma (ccRCC) exhibits a broad range of metastatic phenotypes that have not been systematically studied to date. Here, we analyzed 575 primary and 335 metastatic biopsies across 100 patients with ...
    • Tracking evolution of aromatase inhibitor resistance with circulating tumour DNA analysis in metastatic breast cancer. 

      Fribbens, C; Garcia Murillas, I; Beaney, M; Hrebien, S; O'Leary, B; Kilburn, L; Howarth, K; Epstein, M; Green, E; Rosenfeld, N; Ring, A; Johnston, S; Turner, N (2018-01-01)
      Background: Selection of resistance mutations may play a major role in the development of endocrine resistance. ESR1 mutations are rare in primary breast cancer but have high prevalence in patients treated with aromatase ...
    • Tracking the Evolution of Non-Small-Cell Lung Cancer. 

      Jamal-Hanjani, M; Wilson, GA; McGranahan, N; Birkbak, NJ; Watkins, TBK; Veeriah, S; Shafi, S; Johnson, DH; Mitter, R; Rosenthal, R; Salm, M; Horswell, S; Escudero, M; Matthews, N; Rowan, A; Chambers, T; Moore, DA; Turajlic, S; Xu, H; Lee, S-M; Forster, MD; Ahmad, T; Hiley, CT; Abbosh, C; Falzon, M; Borg, E; Marafioti, T; Lawrence, D; Hayward, M; Kolvekar, S; Panagiotopoulos, N; Janes, SM; Thakrar, R; Ahmed, A; Blackhall, F; Summers, Y; Shah, R; Joseph, L; Quinn, AM; Crosbie, PA; Naidu, B; Middleton, G; Langman, G; Trotter, S; Nicolson, M; Remmen, H; Kerr, K; Chetty, M; Gomersall, L; Fennell, DA; Nakas, A; Rathinam, S; Anand, G; Khan, S; Russell, P; Ezhil, V; Ismail, B; Irvin-Sellers, M; Prakash, V; Lester, JF; Kornaszewska, M; Attanoos, R; Adams, H; Davies, H; Dentro, S; Taniere, P; O'Sullivan, B; Lowe, HL; Hartley, JA; Iles, N; Bell, H; Ngai, Y; Shaw, JA; Herrero, J; Szallasi, Z; Schwarz, RF; Stewart, A; Quezada, SA; Le Quesne, J; Van Loo, P; Dive, C; Hackshaw, A; Swanton, C; TRACERx Consortium (2017-06-01)
      BACKGROUND: Among patients with non-small-cell lung cancer (NSCLC), data on intratumor heterogeneity and cancer genome evolution have been limited to small retrospective cohorts. We wanted to prospectively investigate ...
    • Trans-abdominal in vivo placental vessel occlusion using High Intensity Focused Ultrasound. 

      Shaw, CJ; Rivens, I; Civale, J; Botting, KJ; Ter Haar, G; Giussani, DA; Lees, CC (2018-09-11)
      Pre-clinically, High Intensity Focused Ultrasound (HIFU) has been shown to safely and effectively occlude placental blood vessels in the acute setting, when applied through the uterus. However, further development of the ...
    • Transanal Total Mesorectal Excision 

      Penna, M; Hompes, R; Arnold, S; Wynn, G; Austin, R; Warusavitarne, J; Moran, B; Hanna, GB; Mortensen, NJ; Tekkis, PP (Ovid Technologies (Wolters Kluwer Health), 2017-07)
    • Transcription factor-mediated lineage switching reveals plasticity in primary committed progenitor cells 

      Heyworth, C; Pearson, S; May, G; Enver, T (2002-07-15)
      The developmental plasticity of transplanted adult stem cells challenges the notion that tissue-restricted stem cells have stringently limited lineage potential and prompts a re-evaluation of the stability of lineage ...
    • Transcription factors link mouse WAP-T mammary tumors with human breast cancer 

      Gevensleben, Heidrun (2013-03)
      Mouse models are important tools to decipher the molecular mechanisms of mammary carcinogenesis and to mimic the respective human disease. Despite sharing common phenotypic and genetic features, the proper translation of ...
    • Transcriptional silencing of Polo-like kinase 2 (SNK/PLK2) is a frequent event in B-cell malignancies 

      Syed, N; Smith, P; Sullivan, A; Spender, LC; Dyer, M; Karran, L; O Nions, J; Allday, M; Hoffmann, I; Crawford, D; Griffin, B; Farrell, PJ; Crook, T (AMER SOC HEMATOLOGY, 2006-01-01)
      The Polo-like kinases (Plks) are a highly conserved family of protein kinases that function in regulation of cell cycle and DNA damage-induced checkpoints. Evidence of a tumor suppressor function for the Plks in human ...
    • Transcriptional targeting of acute hypoxia in the tumour stroma is a novel and viable strategy for cancer gene therapy 

      Ingram, N; Porter, CD (2005-07)
      Deregulated tumour growth and neovascularization result in an inadequate tumour blood supply, leading to areas of chronic hypoxia and necrosis. Irregular vascular structure and abnormal tumour physiology also cause erratic ...
    • A Transcriptome-Wide Association Study Among 97,898 Women to Identify Candidate Susceptibility Genes for Epithelial Ovarian Cancer Risk. 

      Lu, Y; Beeghly-Fadiel, A; Wu, L; Guo, X; Li, B; Schildkraut, JM; Im, HK; Chen, YA; Permuth, JB; Reid, BM; Teer, JK; Moysich, KB; Andrulis, IL; Anton-Culver, H; Arun, BK; Bandera, EV; Barkardottir, RB; Barnes, DR; Benitez, J; Bjorge, L; Brenton, J; Butzow, R; Caldes, T; Caligo, MA; Campbell, I; Chang-Claude, J; Claes, KBM; Couch, FJ; Cramer, DW; Daly, MB; deFazio, A; Dennis, J; Diez, O; Domchek, SM; Dörk, T; Easton, DF; Eccles, DM; Fasching, PA; Fortner, RT; Fountzilas, G; Friedman, E; Ganz, PA; Garber, J; Giles, GG; Godwin, AK; Goldgar, DE; Goodman, MT; Greene, MH; Gronwald, J; Hamann, U; Heitz, F; Hildebrandt, MAT; Høgdall, CK; Hollestelle, A; Hulick, PJ; Huntsman, DG; Imyanitov, EN; Isaacs, C; Jakubowska, A; James, P; Karlan, BY; Kelemen, LE; Kiemeney, LA; Kjaer, SK; Kwong, A; Le, ND; Leslie, G; Lesueur, F; Levine, DA; Mattiello, A; May, T; McGuffog, L; McNeish, IA; Merritt, MA; Modugno, F; Montagna, M; Neuhausen, SL; Nevanlinna, H; Nielsen, FC; Nikitina-Zake, L; Nussbaum, RL; Offit, K; Olah, E; Olopade, OI; Olson, SH; Olsson, H; Osorio, A; Park, SK; Parsons, MT; Peeters, PHM; Pejovic, T; Peterlongo, P; Phelan, CM; Pujana, MA; Ramus, SJ; Rennert, G; Risch, H; Rodriguez, GC; Rodríguez-Antona, C; Romieu, I; Rookus, MA; Rossing, MA; Rzepecka, IK; Sandler, DP; Schmutzler, RK; Setiawan, VW; Sharma, P; Sieh, W; Simard, J; Singer, CF; Song, H; Southey, MC; Spurdle, AB; Sutphen, R; Swerdlow, AJ; Teixeira, MR; Teo, SH; Thomassen, M; Tischkowitz, M; Toland, AE; Trichopoulou, A; Tung, N; Tworoger, SS; van Rensburg, EJ; Vanderstichele, A; Vega, A; Edwards, DV; Webb, PM; Weitzel, JN; Wentzensen, N; White, E; Wolk, A; Wu, AH; Yannoukakos, D; Zorn, KK; Gayther, SA; Antoniou, AC; Berchuck, A; Goode, EL; Chenevix-Trench, G; Sellers, TA; Pharoah, PDP; Zheng, W; Long, J (2018-09-15)
      Large-scale genome-wide association studies (GWAS) have identified approximately 35 loci associated with epithelial ovarian cancer (EOC) risk. The majority of GWAS-identified disease susceptibility variants are located in ...
    • Transcriptome-wide association study identifies new candidate susceptibility genes for glioma. 

      Atkins, I; Kinnersley, B; Ostrom, QT; Labreche, K; Il'yasova, D; Armstrong, GN; Eckel-Passow, JE; Schoemaker, MJ; Nöthen, MM; Barnholtz-Sloan, JS; Swerdlow, AJ; Simon, M; Rajaraman, P; Chanock, SJ; Shildkraut, J; Bernstein, JL; Hoffmann, P; Jöckel, K-H; Lai, RK; Claus, EB; Olson, SH; Johansen, C; Wrensch, MR; Melin, B; Jenkins, RB; Sanson, M; Bondy, ML; Houlston, RS (2019-02-01)
      Genome-wide association studies (GWAS) have so far identified 25 loci associated with glioma risk, with most showing specificity for either glioblastoma (GBM) or non-GBM tumors. The majority of these GWAS susceptibility ...
    • A transcriptome-wide association study of 229,000 women identifies new candidate susceptibility genes for breast cancer. 

      Wu, L; Shi, W; Long, J; Guo, X; Michailidou, K; Beesley, J; Bolla, MK; Shu, X-O; Lu, Y; Cai, Q; Al-Ejeh, F; Rozali, E; Wang, Q; Dennis, J; Li, B; Zeng, C; Feng, H; Gusev, A; Barfield, RT; Andrulis, IL; Anton-Culver, H; Arndt, V; Aronson, KJ; Auer, PL; Barrdahl, M; Baynes, C; Beckmann, MW; Benitez, J; Bermisheva, M; Blomqvist, C; Bogdanova, NV; Bojesen, SE; Brauch, H; Brenner, H; Brinton, L; Broberg, P; Brucker, SY; Burwinkel, B; Caldés, T; Canzian, F; Carter, BD; Castelao, JE; Chang-Claude, J; Chen, X; Cheng, T-YD; Christiansen, H; Clarke, CL; NBCS Collaborators; Collée, M; Cornelissen, S; Couch, FJ; Cox, D; Cox, A; Cross, SS; Cunningham, JM; Czene, K; Daly, MB; Devilee, P; Doheny, KF; Dörk, T; Dos-Santos-Silva, I; Dumont, M; Dwek, M; Eccles, DM; Eilber, U; Eliassen, AH; Engel, C; Eriksson, M; Fachal, L; Fasching, PA; Figueroa, J; Flesch-Janys, D; Fletcher, O; Flyger, H; Fritschi, L; Gabrielson, M; Gago-Dominguez, M; Gapstur, SM; García-Closas, M; Gaudet, MM; Ghoussaini, M; Giles, GG; Goldberg, MS; Goldgar, DE; González-Neira, A; Guénel, P; Hahnen, E; Haiman, CA; Håkansson, N; Hall, P; Hallberg, E; Hamann, U; Harrington, P; Hein, A; Hicks, B; Hillemanns, P; Hollestelle, A; Hoover, RN; Hopper, JL; Huang, G; Humphreys, K; Hunter, DJ; Jakubowska, A; Janni, W; John, EM; Johnson, N; Jones, K; Jones, ME; Jung, A; Kaaks, R; Kerin, MJ; Khusnutdinova, E; Kosma, V-M; Kristensen, VN; Lambrechts, D; Le Marchand, L; Li, J; Lindström, S; Lissowska, J; Lo, W-Y; Loibl, S; Lubinski, J; Luccarini, C; Lux, MP; MacInnis, RJ; Maishman, T; Kostovska, IM; Mannermaa, A; Manson, JE; Margolin, S; Mavroudis, D; Meijers-Heijboer, H; Meindl, A; Menon, U; Meyer, J; Mulligan, AM; Neuhausen, SL; Nevanlinna, H; Neven, P; Nielsen, SF; Nordestgaard, BG; Olopade, OI; Olson, JE; Olsson, H; Peterlongo, P; Peto, J; Plaseska-Karanfilska, D; Prentice, R; Presneau, N; Pylkäs, K; Rack, B; Radice, P; Rahman, N; Rennert, G; Rennert, HS; Rhenius, V; Romero, A; Romm, J; Rudolph, A; Saloustros, E; Sandler, DP; Sawyer, EJ; Schmidt, MK; Schmutzler, RK; Schneeweiss, A; Scott, RJ; Scott, CG; Seal, S; Shah, M; Shrubsole, MJ; Smeets, A; Southey, MC; Spinelli, JJ; Stone, J; Surowy, H; Swerdlow, AJ; Tamimi, RM; Tapper, W; Taylor, JA; Terry, MB; Tessier, DC; Thomas, A; Thöne, K; Tollenaar, RAEM; Torres, D; Truong, T; Untch, M; Vachon, C; Van Den Berg, D; Vincent, D; Waisfisz, Q; Weinberg, CR; Wendt, C; Whittemore, AS; Wildiers, H; Willett, WC; Winqvist, R; Wolk, A; Xia, L; Yang, XR; Ziogas, A; Ziv, E; kConFab/AOCS Investigators; Dunning, AM; Pharoah, PDP; Simard, J; Milne, RL; Edwards, SL; Kraft, P; Easton, DF; Chenevix-Trench, G; Zheng, W (2018-07)
      The breast cancer risk variants identified in genome-wide association studies explain only a small fraction of the familial relative risk, and the genes responsible for these associations remain largely unknown. To identify ...