Now showing items 21-31 of 31

    • Genomic Determinants of Protein Abundance Variation in Colorectal Cancer Cells. 

      Roumeliotis, TI; Williams, SP; Gonçalves, E; Alsinet, C; Del Castillo Velasco-Herrera, M; Aben, N; Ghavidel, FZ; Michaut, M; Schubert, M; Price, S; Wright, JC; Yu, L; Yang, M; Dienstmann, R; Guinney, J; Beltrao, P; Brazma, A; Pardo, M; Stegle, O; Adams, DJ; Wessels, L; Saez-Rodriguez, J; McDermott, U; Choudhary, JS (2017-08)
      Assessing the impact of genomic alterations on protein networks is fundamental in identifying the mechanisms that shape cancer heterogeneity. We have used isobaric labeling to characterize the proteomic landscapes of 50 ...
    • Identification of independent association signals and putative functional variants for breast cancer risk through fine-scale mapping of the 12p11 locus. 

      Zeng, C; Guo, X; Long, J; Kuchenbaecker, KB; Droit, A; Michailidou, K; Ghoussaini, M; Kar, S; Freeman, A; Hopper, JL; Milne, RL; Bolla, MK; Wang, Q; Dennis, J; Agata, S; Ahmed, S; Aittomäki, K; Andrulis, IL; Anton-Culver, H; Antonenkova, NN; Arason, A; Arndt, V; Arun, BK; Arver, B; Bacot, F; Barrowdale, D; Baynes, C; Beeghly-Fadiel, A; Benitez, J; Bermisheva, M; Blomqvist, C; Blot, WJ; Bogdanova, NV; Bojesen, SE; Bonanni, B; Borresen-Dale, A-L; Brand, JS; Brauch, H; Brennan, P; Brenner, H; Broeks, A; Brüning, T; Burwinkel, B; Buys, SS; Cai, Q; Caldes, T; Campbell, I; Carpenter, J; Chang-Claude, J; Choi, J-Y; Claes, KBM; Clarke, C; Cox, A; Cross, SS; Czene, K; Daly, MB; de la Hoya, M; De Leeneer, K; Devilee, P; Diez, O; Domchek, SM; Doody, M; Dorfling, CM; Dörk, T; Dos-Santos-Silva, I; Dumont, M; Dwek, M; Dworniczak, B; Egan, K; Eilber, U; Einbeigi, Z; Ejlertsen, B; Ellis, S; Frost, D; Lalloo, F; EMBRACE; Fasching, PA; Figueroa, J; Flyger, H; Friedlander, M; Friedman, E; Gambino, G; Gao, Y-T; Garber, J; García-Closas, M; Gehrig, A; Damiola, F; Lesueur, F; Mazoyer, S; Stoppa-Lyonnet, D; behalf of GEMO Study Collaborators; Giles, GG; Godwin, AK; Goldgar, DE; González-Neira, A; Greene, MH; Guénel, P; Haeberle, L; Haiman, CA; Hallberg, E; Hamann, U; Hansen, TVO; Hart, S; Hartikainen, JM; Hartman, M; Hassan, N; Healey, S; Hogervorst, FBL; Verhoef, S; HEBON; Hendricks, CB; Hillemanns, P; Hollestelle, A; Hulick, PJ; Hunter, DJ; Imyanitov, EN; Isaacs, C; Ito, H; Jakubowska, A; Janavicius, R; Jaworska-Bieniek, K; Jensen, UB; John, EM; Joly Beauparlant, C; Jones, M; Kabisch, M; Kang, D; Karlan, BY; Kauppila, S; Kerin, MJ; Khan, S; Khusnutdinova, E; Knight, JA; Konstantopoulou, I; Kraft, P; Kwong, A; Laitman, Y; Lambrechts, D; Lazaro, C; Le Marchand, L; Lee, CN; Lee, MH; Lester, J; Li, J; Liljegren, A; Lindblom, A; Lophatananon, A; Lubinski, J; Mai, PL; Mannermaa, A; Manoukian, S; Margolin, S; Marme, F; Matsuo, K; McGuffog, L; Meindl, A; Menegaux, F; Montagna, M; Muir, K; Mulligan, AM; Nathanson, KL; Neuhausen, SL; Nevanlinna, H; Newcomb, PA; Nord, S; Nussbaum, RL; Offit, K; Olah, E; Olopade, OI; Olswold, C; Osorio, A; Papi, L; Park-Simon, T-W; Paulsson-Karlsson, Y; Peeters, S; Peissel, B; Peterlongo, P; Peto, J; Pfeiler, G; Phelan, CM; Presneau, N; Radice, P; Rahman, N; Ramus, SJ; Rashid, MU; Rennert, G; Rhiem, K; Rudolph, A; Salani, R; Sangrajrang, S; Sawyer, EJ; Schmidt, MK; Schmutzler, RK; Schoemaker, MJ; Schürmann, P; Seynaeve, C; Shen, C-Y; Shrubsole, MJ; Shu, X-O; Sigurdson, A; Singer, CF; Slager, S; Soucy, P; Southey, M; Steinemann, D; Swerdlow, A; Szabo, CI; Tchatchou, S; Teixeira, MR; Teo, SH; Terry, MB; Tessier, DC; Teulé, A; Thomassen, M; Tihomirova, L; Tischkowitz, M; Toland, AE; Tung, N; Turnbull, C; van den Ouweland, AMW; van Rensburg, EJ; Ven den Berg, D; Vijai, J; Wang-Gohrke, S; Weitzel, JN; Whittemore, AS; Winqvist, R; Wong, TY; Wu, AH; Yannoukakos, D; Yu, J-C; Pharoah, PDP; Hall, P; Chenevix-Trench, G; KConFab; AOCS Investigators; Dunning, AM; Simard, J; Couch, FJ; Antoniou, AC; Easton, DF; Zheng, W (2016-06-21)
      Background Multiple recent genome-wide association studies (GWAS) have identified a single nucleotide polymorphism (SNP), rs10771399, at 12p11 that is associated with breast cancer risk.Method We performed a fine-scale ...
    • Identification of multiple risk loci and regulatory mechanisms influencing susceptibility to multiple myeloma. 

      Went, M; Sud, A; Försti, A; Halvarsson, B-M; Weinhold, N; Kimber, S; van Duin, M; Thorleifsson, G; Holroyd, A; Johnson, DC; Li, N; Orlando, G; Law, PJ; Ali, M; Chen, B; Mitchell, JS; Gudbjartsson, DF; Kuiper, R; Stephens, OW; Bertsch, U; Broderick, P; Campo, C; Bandapalli, OR; Einsele, H; Gregory, WA; Gullberg, U; Hillengass, J; Hoffmann, P; Jackson, GH; Jöckel, K-H; Johnsson, E; Kristinsson, SY; Mellqvist, U-H; Nahi, H; Easton, D; Pharoah, P; Dunning, A; Peto, J; Canzian, F; Swerdlow, A; Eeles, RA; Kote-Jarai, Z; Muir, K; Pashayan, N; Nickel, J; Nöthen, MM; Rafnar, T; Ross, FM; da Silva Filho, MI; Thomsen, H; Turesson, I; Vangsted, A; Andersen, NF; Waage, A; Walker, BA; Wihlborg, A-K; Broyl, A; Davies, FE; Thorsteinsdottir, U; Langer, C; Hansson, M; Goldschmidt, H; Kaiser, M; Sonneveld, P; Stefansson, K; Morgan, GJ; Hemminki, K; Nilsson, B; Houlston, RS; PRACTICAL consortium (2018-09-13)
      Genome-wide association studies (GWAS) have transformed our understanding of susceptibility to multiple myeloma (MM), but much of the heritability remains unexplained. We report a new GWAS, a meta-analysis with previous ...
    • Identification of nine new susceptibility loci for endometrial cancer. 

      O'Mara, TA; Glubb, DM; Amant, F; Annibali, D; Ashton, K; Attia, J; Auer, PL; Beckmann, MW; Black, A; Bolla, MK; Brauch, H; Brenner, H; Brinton, L; Buchanan, DD; Burwinkel, B; Chang-Claude, J; Chanock, SJ; Chen, C; Chen, MM; Cheng, THT; Clarke, CL; Clendenning, M; Cook, LS; Couch, FJ; Cox, A; Crous-Bous, M; Czene, K; Day, F; Dennis, J; Depreeuw, J; Doherty, JA; Dörk, T; Dowdy, SC; Dürst, M; Ekici, AB; Fasching, PA; Fridley, BL; Friedenreich, CM; Fritschi, L; Fung, J; García-Closas, M; Gaudet, MM; Giles, GG; Goode, EL; Gorman, M; Haiman, CA; Hall, P; Hankison, SE; Healey, CS; Hein, A; Hillemanns, P; Hodgson, S; Hoivik, EA; Holliday, EG; Hopper, JL; Hunter, DJ; Jones, A; Krakstad, C; Kristensen, VN; Lambrechts, D; Marchand, LL; Liang, X; Lindblom, A; Lissowska, J; Long, J; Lu, L; Magliocco, AM; Martin, L; McEvoy, M; Meindl, A; Michailidou, K; Milne, RL; Mints, M; Montgomery, GW; Nassir, R; Olsson, H; Orlow, I; Otton, G; Palles, C; Perry, JRB; Peto, J; Pooler, L; Prescott, J; Proietto, T; Rebbeck, TR; Risch, HA; Rogers, PAW; Rübner, M; Runnebaum, I; Sacerdote, C; Sarto, GE; Schumacher, F; Scott, RJ; Setiawan, VW; Shah, M; Sheng, X; Shu, X-O; Southey, MC; Swerdlow, AJ; Tham, E; Trovik, J; Turman, C; Tyrer, JP; Vachon, C; VanDen Berg, D; Vanderstichele, A; Wang, Z; Webb, PM; Wentzensen, N; Werner, HMJ; Winham, SJ; Wolk, A; Xia, L; Xiang, Y-B; Yang, HP; Yu, H; Zheng, W; Pharoah, PDP; Dunning, AM; Kraft, P; De Vivo, I; Tomlinson, I; Easton, DF; Spurdle, AB; Thompson, DJ (2018-08-09)
      Endometrial cancer is the most commonly diagnosed cancer of the female reproductive tract in developed countries. Through genome-wide association studies (GWAS), we have previously identified eight risk loci for endometrial ...
    • Identification of Novel Susceptibility Loci and Genes for Prostate Cancer Risk: A Transcriptome-Wide Association Study in Over 140,000 European Descendants. 

      Wu, L; Wang, J; Cai, Q; Cavazos, TB; Emami, NC; Long, J; Shu, X-O; Lu, Y; Guo, X; Bauer, JA; Pasaniuc, B; Penney, KL; Freedman, ML; Kote-Jarai, Z; Witte, JS; Haiman, CA; Eeles, RA; Zheng, W; PRACTICAL, CRUK, BPC3, CAPS, PEGASUS Consortia (2019-07)
      Genome-wide association study-identified prostate cancer risk variants explain only a relatively small fraction of its familial relative risk, and the genes responsible for many of these identified associations remain ...
    • Identification of susceptibility pathways for the role of chromosome 15q25.1 in modifying lung cancer risk. 

      Ji, X; Bossé, Y; Landi, MT; Gui, J; Xiao, X; Qian, D; Joubert, P; Lamontagne, M; Li, Y; Gorlov, I; de Biasi, M; Han, Y; Gorlova, O; Hung, RJ; Wu, X; McKay, J; Zong, X; Carreras-Torres, R; Christiani, DC; Caporaso, N; Johansson, M; Liu, G; Bojesen, SE; Le Marchand, L; Albanes, D; Bickeböller, H; Aldrich, MC; Bush, WS; Tardon, A; Rennert, G; Chen, C; Teare, MD; Field, JK; Kiemeney, LA; Lazarus, P; Haugen, A; Lam, S; Schabath, MB; Andrew, AS; Shen, H; Hong, Y-C; Yuan, J-M; Bertazzi, PA; Pesatori, AC; Ye, Y; Diao, N; Su, L; Zhang, R; Brhane, Y; Leighl, N; Johansen, JS; Mellemgaard, A; Saliba, W; Haiman, C; Wilkens, L; Fernandez-Somoano, A; Fernandez-Tardon, G; van der Heijden, EHFM; Kim, JH; Dai, J; Hu, Z; Davies, MPA; Marcus, MW; Brunnström, H; Manjer, J; Melander, O; Muller, DC; Overvad, K; Trichopoulou, A; Tumino, R; Doherty, J; Goodman, GE; Cox, A; Taylor, F; Woll, P; Brüske, I; Manz, J; Muley, T; Risch, A; Rosenberger, A; Grankvist, K; Johansson, M; Shepherd, F; Tsao, M-S; Arnold, SM; Haura, EB; Bolca, C; Holcatova, I; Janout, V; Kontic, M; Lissowska, J; Mukeria, A; Ognjanovic, S; Orlowski, TM; Scelo, G; Swiatkowska, B; Zaridze, D; Bakke, P; Skaug, V; Zienolddiny, S; Duell, EJ; Butler, LM; Koh, W-P; Gao, Y-T; Houlston, R; McLaughlin, J; Stevens, V; Nickle, DC; Obeidat, M; Timens, W; Zhu, B; Song, L; Artigas, MS; Tobin, MD; Wain, LV; Gu, F; Byun, J; Kamal, A; Zhu, D; Tyndale, RF; Wei, W-Q; Chanock, S; Brennan, P; Amos, CI (2018-08-13)
      Genome-wide association studies (GWAS) identified the chromosome 15q25.1 locus as a leading susceptibility region for lung cancer. However, the pathogenic pathways, through which susceptibility SNPs within chromosome 15q25.1 ...
    • Multiple myeloma risk variant at 7p15.3 creates an IRF4-binding site and interferes with CDCA7L expression. 

      Li, N; Johnson, DC; Weinhold, N; Studd, JB; Orlando, G; Mirabella, F; Mitchell, JS; Meissner, T; Kaiser, M; Goldschmidt, H; Hemminki, K; Morgan, GJ; Houlston, RS (2016-11-24)
      Genome-wide association studies have identified several risk loci for multiple myeloma (MM); however, the mechanisms by which they influence MM are unknown. Here by using genetic association data and functional characterization, ...
    • Prostate cancer risk regions at 8q24 and 17q24 are differentially associated with somatic TMPRSS2:ERG fusion status. 

      Luedeke, M; Rinckleb, AE; FitzGerald, LM; Geybels, MS; Schleutker, J; Eeles, RA; Teixeira, MR; Cannon-Albright, L; Ostrander, EA; Weikert, S; Herkommer, K; Wahlfors, T; Visakorpi, T; Leinonen, KA; Tammela, TLJ; Cooper, CS; Kote-Jarai, Z; Edwards, S; Goh, CL; McCarthy, F; Parker, C; Flohr, P; Paulo, P; Jerónimo, C; Henrique, R; Krause, H; Wach, S; Lieb, V; Rau, TT; Vogel, W; Kuefer, R; Hofer, MD; Perner, S; Rubin, MA; Agarwal, AM; Easton, DF; Al Olama, AA; Benlloch, S; PRACTICAL consortium; Hoegel, J; Stanford, JL; Maier, C (2016-12)
      Molecular and epidemiological differences have been described between TMPRSS2:ERG fusion-positive and fusion-negative prostate cancer (PrCa). Assuming two molecularly distinct subtypes, we have examined 27 common PrCa risk ...
    • Susceptibility loci of CNOT6 in the general mRNA degradation pathway and lung cancer risk-A re-analysis of eight GWASs. 

      Zhou, F; Wang, Y; Liu, H; Ready, N; Han, Y; Hung, RJ; Brhane, Y; McLaughlin, J; Brennan, P; Bickeböller, H; Rosenberger, A; Houlston, RS; Caporaso, N; Landi, MT; Brüske, I; Risch, A; Ye, Y; Wu, X; Christiani, DC; Goodman, G; Chen, C; Transdisciplinary Research in Cancer of the Lung (TRICL) Research Team; Amos, CI; Wei, Q (2017-04)
      Purpose mRNA degradation is an important regulatory step for controlling gene expression and cell functions. Genetic abnormalities involved in mRNA degradation genes were found to be associated with cancer risks. Therefore, ...
    • Transcriptome-Wide Association Study Identifies New Candidate Susceptibility Genes for Glioma. 

      Atkins, I; Kinnersley, B; Ostrom, QT; Labreche, K; Il'yasova, D; Armstrong, GN; Eckel-Passow, JE; Schoemaker, MJ; Nöthen, MM; Barnholtz-Sloan, JS; Swerdlow, AJ; Simon, M; Rajaraman, P; Chanock, SJ; Shildkraut, J; Bernstein, JL; Hoffmann, P; Jöckel, K-H; Lai, RK; Claus, EB; Olson, SH; Johansen, C; Wrensch, MR; Melin, B; Jenkins, RB; Sanson, M; Bondy, ML; Houlston, RS (2019-04)
      Genome-wide association studies (GWAS) have so far identified 25 loci associated with glioma risk, with most showing specificity for either glioblastoma (GBM) or non-GBM tumors. The majority of these GWAS susceptibility ...
    • Transcriptome-wide association study of multiple myeloma identifies candidate susceptibility genes. 

      Went, M; Kinnersley, B; Sud, A; Johnson, DC; Weinhold, N; Försti, A; van Duin, M; Orlando, G; Mitchell, JS; Kuiper, R; Walker, BA; Gregory, WM; Hoffmann, P; Jackson, GH; Nöthen, MM; da Silva Filho, MI; Thomsen, H; Broyl, A; Davies, FE; Thorsteinsdottir, U; Hansson, M; Kaiser, M; Sonneveld, P; Goldschmidt, H; Stefansson, K; Hemminki, K; Nilsson, B; Morgan, GJ; Houlston, RS (2019-08-20)
      Background While genome-wide association studies (GWAS) of multiple myeloma (MM) have identified variants at 23 regions influencing risk, the genes underlying these associations are largely unknown. To identify candidate ...