Browsing by author "Nill, Simeon"
Now showing items 41-60 of 61
-
Motion monitoring during a course of lung radiotherapy with anchored electromagnetic transponders : Quantification of inter- and intrafraction motion and variability of relative transponder positions.
Schmitt, D; Nill, S; Roeder, F; Gompelmann, D; Herth, F; et al. (SPRINGER HEIDELBERG, 2017-10-01)PURPOSE: Anchored electromagnetic transponders for tumor motion monitoring during lung radiotherapy were clinically evaluated. First, intrafractional motion patterns were analyzed as well as their interfractional variations. ... -
MRI-guided adaptive radiotherapy for prostate cancer: When do we need to account for intra-fraction motion?
Lawes, R; Barnes, H; Herbert, T; Mitchell, A; Nill, S; et al. (ELSEVIER IRELAND LTD, 2022-11-01)A shift of the daily plan can mitigate target position changes that occur between daily MR acquisition and treatment for MR-linac radiotherapy, but increases the session time. We demonstrated that our workflow strategy and ... -
New target volume delineation and PTV strategies to further personalise radiotherapy.
Bernstein, D; Taylor, A; Nill, S; Oelfke, U (IOP PUBLISHING LTD, 2021-02-25)Target volume delineation uncertainty (DU) is arguably one of the largest geometric uncertainties in radiotherapy that are accounted for using planning target volume (PTV) margins. Geometrical uncertainties are typically ... -
Novel adaptive beam-dependent margins for additional OAR sparing.
Tsang, HS; Kamerling, CP; Ziegenhein, P; Nill, S; Oelfke, U (IOP PUBLISHING LTD, 2018-10-29)Margins are employed in radiotherapy treatment planning to mitigate the dosimetric effects of geometric uncertainties for the clinical target volume (CTV). Unfortunately, whilst the use of margins can increase the probability ... -
Online adaptive radiotherapy for head and neck cancers on the MR linear Accelerator: Introducing a novel modified Adapt-to-Shape approach.
Gupta, A; Dunlop, A; Mitchell, A; McQuaid, D; Nill, S; et al. (ELSEVIER IRELAND LTD, 2021-11-19)INTRODUCTION: The Elekta Unity MR-Linac (MRL) has enabled adaptive radiotherapy (ART) for patients with head and neck cancers (HNC). Adapt-To-Shape-Lite (ATS-Lite) is a novel Adapt-to-Shape strategy that provides ART without ... -
Online dose reconstruction for tracked volumetric arc therapy: Real-time implementation and offline quality assurance for prostate SBRT.
Kamerling, CP; Fast, MF; Ziegenhein, P; Menten, MJ; Nill, S; et al. (WILEY, 2017-08-20)PURPOSE: Firstly, this study provides a real-time implementation of online dose reconstruction for tracked volumetric arc therapy (VMAT). Secondly, this study describes a novel offline quality assurance tool, based on ... -
Rapid 4D-MRI reconstruction using a deep radial convolutional neural network: Dracula.
Freedman, JN; Gurney-Champion, OJ; Nill, S; Shiarli, A-M; Bainbridge, HE; et al. (ELSEVIER IRELAND LTD, 2021-06-01)BACKGROUND AND PURPOSE: 4D and midposition MRI could inform plan adaptation in lung and abdominal MR-guided radiotherapy. We present deep learning-based solutions to overcome long 4D-MRI reconstruction times while maintaining ... -
Real-time 4D dose reconstruction for tracked dynamic MLC deliveries for lung SBRT.
Kamerling, CP; Fast, MF; Ziegenhein, P; Menten, MJ; Nill, S; et al. (WILEY, 2016-11-01)PURPOSE: This study provides a proof of concept for real-time 4D dose reconstruction for lung stereotactic body radiation therapy (SBRT) with multileaf collimator (MLC) tracking and assesses the impact of tumor tracking ... -
Real-time auto-adaptive margin generation for MLC-tracked radiotherapy.
Glitzner, M; Fast, MF; de Senneville, BD; Nill, S; Oelfke, U; et al. (IOP PUBLISHING LTD, 2017-01-07)In radiotherapy, abdominal and thoracic sites are candidates for performing motion tracking. With real-time control it is possible to adjust the multileaf collimator (MLC) position to the target position. However, positions ... -
Realizing the potential of magnetic resonance image guided radiotherapy in gynaecological and rectal cancer.
White, IM; Scurr, E; Wetscherek, A; Brown, G; Sohaib, A; et al. (BRITISH INST RADIOLOGY, 2019-05-14)CT-based radiotherapy workflow is limited by poor soft tissue definition in the pelvis and reliance on rigid registration methods. Current image-guided radiotherapy and adaptive radiotherapy models therefore have limited ... -
Respiratory motion modelling for MR-guided lung cancer radiotherapy: model development and geometric accuracy evaluation.
Eiben, B; Bertholet, J; Tran, EH; Wetscherek, A; Shiarli, A-M; et al. (IOP Publishing Ltd, 2024-02-19)Objective.Respiratory motion of lung tumours and adjacent structures is challenging for radiotherapy. Online MR-imaging cannot currently provide real-time volumetric information of the moving patient anatomy, therefore ... -
Response to comment by G. Borasi.
Brüningk, SC; Rivens, I; Nill, S; Ter Haar, G; Oelfke, U (TAYLOR & FRANCIS LTD, 2017-08-16) -
Super-resolution T2-weighted 4D MRI for image guided radiotherapy.
Freedman, JN; Collins, DJ; Gurney-Champion, OJ; McClelland, JR; Nill, S; et al. (ELSEVIER IRELAND LTD, 2018-12-01)BACKGROUND AND PURPOSE: The superior soft-tissue contrast of 4D-T2w MRI motivates its use for delineation in radiotherapy treatment planning. We address current limitations of slice-selective implementations, including ... -
Synthetic 4D-CT of the thorax for treatment plan adaptation on MR-guided radiotherapy systems.
Freedman, JN; Bainbridge, HE; Nill, S; Collins, DJ; Kachelrieß, M; et al. (IOP PUBLISHING LTD, 2019-05-23)MR-guided radiotherapy treatment planning utilises the high soft-tissue contrast of MRI to reduce uncertainty in delineation of the target and organs at risk. Replacing 4D-CT with MRI-derived synthetic 4D-CT would support ... -
T2-Weighted 4D Magnetic Resonance Imaging for Application in Magnetic Resonance-Guided Radiotherapy Treatment Planning.
Freedman, JN; Collins, DJ; Bainbridge, H; Rank, CM; Nill, S; et al. (LIPPINCOTT WILLIAMS & WILKINS, 2017-10-01)OBJECTIVES: The aim of this study was to develop and verify a method to obtain good temporal resolution T2-weighted 4-dimensional (4D-T2w) magnetic resonance imaging (MRI) by using motion information from T1-weighted 4D ... -
The impact of 2D cine MR imaging parameters on automated tumor and organ localization for MR-guided real-time adaptive radiotherapy.
Menten, MJ; Fast, MF; Wetscherek, A; Rank, CM; Kachelrieß, M; et al. (IOP PUBLISHING LTD, 2018-11-22)2D cine MR imaging may be utilized to monitor rapidly moving tumors and organs-at-risk for real-time adaptive radiotherapy. This study systematically investigates the impact of geometric imaging parameters on the ability ... -
Treating locally advanced lung cancer with a 1.5T MR-Linac - Effects of the magnetic field and irradiation geometry on conventionally fractionated and isotoxic dose-escalated radiotherapy.
Bainbridge, HE; Menten, MJ; Fast, MF; Nill, S; Oelfke, U; et al. (ELSEVIER IRELAND LTD, 2017-11-01)PURPOSE: This study investigates the feasibility and potential benefits of radiotherapy with a 1.5T MR-Linac for locally advanced non-small cell lung cancer (LA NSCLC) patients. MATERIAL AND METHODS: Ten patients with LA ... -
Treatment planning optimization with beam motion modeling for dynamic arc delivery of SBRT using Cyberknife with multileaf collimation.
Bedford, JL; Tsang, HS; Nill, S; Oelfke, U (WILEY, 2019-12-01)PURPOSE: The use of dynamic arcs for delivery of stereotactic body radiation therapy (SBRT) on Cyberknife is investigated, with a view to improving treatment times. This study investigates the required modeling of robot ... -
A treatment planning study of combined carbon ion-beam plus photon intensity-modulated radiotherapy.
Schuppert, C; Paul, A; Nill, S; Schwahofer, A; Debus, J; et al. (ELSEVIER, 2020-07-01)BACKGROUND AND PURPOSE: Combined photon intensity-modulated radiotherapy (IMRT) and sequential dose-escalated carbon ion beam therapy (IBT) is a technically advanced treatment option for head and neck malignancies. We ... -
Understanding the Benefit of Magnetic Resonance-guided Adaptive Radiotherapy in Rectal Cancer Patients: a Single-centre Study.
Ingle, M; White, I; Chick, J; Stankiewicz, H; Mitchell, A; et al. (ELSEVIER SCIENCE LONDON, 2022-11-03)AIMS: Neoadjuvant chemoradiotherapy followed by surgery is the mainstay of treatment for patients with rectal cancer. Standard clinical target volume (CTV) to planning target volume (PTV) margins of 10 mm are used to ...