Browsing by title
Now showing items 46-65 of 5300
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A common variant at the TERT-CLPTM1L locus is associated with estrogen receptor-negative breast cancer
(2011-12)Estrogen receptor (ER)-negative breast cancer shows a higher incidence in women of African ancestry compared to women of European ancestry. In search of common risk alleles for ER-negative breast cancer, we combined ... -
A comparative study of short-term outcomes of colorectal cancer surgery in the elderly population
(Informa UK Limited, 2017-09-03) -
A comparison between cobalt and linear accelerator-based treatment plans for conformal and intensity-modulated radiotherapy
(BRITISH INST RADIOLOGY, 2008-04)The simplicity of cobalt units gives them the advantage ofreduced maintenance, running costs and downtime when compared with linear accelerators. However, treatments carried out on such units are typically limited to simple ... -
A comparison of flow cytometry, bone marrow biopsy, and bone marrow aspirates in the detection of lymphoid infiltration in B cell disorders
(2003-02)Aims: To evaluate the diagnostic value of bone marrow aspirates, trephine biopsies (BMB), and flow cytometry (FC) in the assessment of bone marrow infiltration in chronic lymphoid disorders. Methods: Investigations were ... -
A comparison of HPV DNA testing and liquid based cytology over three rounds of primary cervical screening: Extended follow up in the ARTISTIC trial
(ELSEVIER SCI LTD, 2011-04)Background: The additional sensitivity of HPV testing compared with cytology could permit extended cervical screening intervals. We wished to determine, through a further (third) round of screening in the ARTISTIC trial, ... -
A comparison of operative outcomes between standard and robotic laparoscopic surgery for endometrial cancer: A systematic review and meta-analysis.
(2017-12)Background Evidence has been systematically assessed comparing robotic with standard laparoscopy for treatment of endometrial cancer.Methods A search of Medline, Embase and Cochrane databases was performed until 30th October ... -
A comparison of the diagnostic value of MRI and 18 F-FDG-PET/CT in suspected spondylodiscitis.
(2017-02)Purpose The purpose of this study was to evaluate the diagnostic value of 18 F-fluorodeoxyglucose (FDG) positron emission tomography and computed tomography (PET/CT scan) and magnetic resonance imaging (MRI) in diagnosing ... -
A comparison of the left thoracoabdominal and Ivor–Lewis esophagectomy
(Oxford University Press (OUP), 2018-03-01)SUMMARY The purpose of this study was to assess the oncological outcomes of a large multicenter series of left thoracoabdominal esophagectomies, and compare these to the more widely utilized Ivor–Lewis esophagectomy. With ... -
A Compendium of Co-regulated Protein Complexes in Breast Cancer Reveals Collateral Loss Events.
(2017-10-11)Protein complexes are responsible for the bulk of activities within the cell, but how their behavior and abundance varies across tumors remains poorly understood. By combining proteomic profiles of breast tumors with a ... -
A comprehensive catalogue of somatic mutations from a human cancer genome
(NATURE PUBLISHING GROUP, 2010-01)All cancers carry somatic mutations. A subset of these somatic alterations, termed driver mutations, confer selective growth advantage and are implicated in cancer development, whereas the remainder are passengers. Here ... -
A comprehensive map of molecular drug targets.
(2017-01)The success of mechanism-based drug discovery depends on the definition of the drug target. This definition becomes even more important as we try to link drug response to genetic variation, understand stratified clinical ... -
A comprehensive model for heat-induced radio-sensitisation.
(2018-06)Combined radiotherapy (RT) and hyperthermia (HT) treatments may improve treatment outcome by heat induced radio-sensitisation. We propose an empirical cell survival model (AlphaR model) to describe this multimodality ... -
A comprehensive model for the proliferation-quiescence decision in response to endogenous DNA damage in human cells.
(2018-03)Human cells that suffer mild DNA damage can enter a reversible state of growth arrest known as quiescence. This decision to temporarily exit the cell cycle is essential to prevent the propagation of mutations, and most ... -
A comprehensive nomenclature for serine proteases with homology to tissue kallikreins
(WALTER DE GRUYTER & CO, 2006-06)The human kallikrein locus on chromosome 19q13.3-13.4 contains kallikrein 1 - the tissue kallikrein - and 14 related serine proteases. Recent investigations into their function and evolution have indicated that the present ... -
A computerized volumetric segmentation method applicable to multi-centre MRI data to support computer-aided breast tissue analysis, density assessment and lesion localization.
(2017-01)Density assessment and lesion localization in breast MRI require accurate segmentation of breast tissues. A fast, computerized algorithm for volumetric breast segmentation, suitable for multi-centre data, has been developed, ... -
A convolutional neural network for contouring metastatic lymph nodes on diffusion-weighted magnetic resonance images for assessment of radiotherapy response.
(2020-07)Background and purpose Retrieving quantitative parameters from magnetic resonance imaging (MRI), e.g. for early assessment of radiotherapy treatment response, necessitates contouring regions of interest, which is time-consuming ... -
A Cost-Effectiveness Evaluation of Germline BRCA1 and BRCA2 Testing in UK Women with Ovarian Cancer.
(2017-04)Objectives To evaluate the long-term cost-effectiveness of germline BRCA1 and BRCA2 (collectively termed "BRCA") testing in women with epithelial ovarian cancer, and testing for the relevant mutation in first- and second-degree ... -
A critical evaluation of the approaches to targeted protein degradation for drug discovery.
(2019-04)There is a great deal of excitement around the concept of targeting proteins for degradation as an alternative to conventional inhibitory small molecules and antibodies. Protein degradation can be undertaken by bifunctional ... -
A Cross-Cancer Genetic Association Analysis of the DNA Repair and DNA Damage Signaling Pathways for Lung, Ovary, Prostate, Breast, and Colorectal Cancer.
(2016-01)Background DNA damage is an established mediator of carcinogenesis, although genome-wide association studies (GWAS) have identified few significant loci. This cross-cancer site, pooled analysis was performed to increase ...
