Now showing items 1225-1244 of 4652

    • Development of biomarker assays to dissect subtype-specific heterogeneity and anti-EGFR treatment response in colorectal cancer 

      Fontana, E (2020-08-31)
      Colorectal cancer (CRC) is the third most frequently diagnosed type of cancer and the second leading cause of cancer deaths worldwide. Although extensive biological heterogeneity at multiple "-omics" levels has been ...
    • Development of Clinical Criteria for Functional Assessment to Predict Primary Nonfunction of High-Risk Livers Using Normothermic Machine Perfusion. 

      Mergental, H; Stephenson, BTF; Laing, RW; Kirkham, AJ; Neil, DAH; Wallace, LL; Boteon, YL; Widmer, J; Bhogal, RH; Perera, MTPR; Smith, A; Reynolds, GM; Yap, C; Hübscher, SG; Mirza, DF; Afford, SC (2018-10)
      Increased use of high-risk allografts is critical to meet the demand for liver transplantation. We aimed to identify criteria predicting viability of organs, currently declined for clinical transplantation, using functional ...
    • Development of combination therapies to maximize the impact of KRAS-G12C inhibitors in lung cancer. 

      Molina-Arcas, M; Moore, C; Rana, S; van Maldegem, F; Mugarza, E; Romero-Clavijo, P; Herbert, E; Horswell, S; Li, L-S; Janes, MR; Hancock, DC; Downward, J (2019-09)
      KRAS represents an excellent therapeutic target in lung cancer, the most commonly mutated form of which can now be blocked using KRAS-G12C mutant-specific inhibitory trial drugs. Lung adenocarcinoma cells harboring KRAS ...
    • Development of free-energy-based models for chaperonin containing TCP-1 mediated folding of actin 

      Altschuler, GM; Willison, KR (ROYAL SOC, 2008-12-06)
      A free-energy-based approach is used to describe the mechanism through which chaperonin-containing TCP-1 (CCT) folds the. lament-forming cytoskeletal protein actin, which is one of its primary substrates. The experimental ...
    • Development of methods to assess the predictive power of pre-therapy imaging for selective internal radiation therapy 

      Craig, A (2020-12-31)
      Pre-therapy Technetium-99m (99mTc)-MAA SPECT may be used to predict the 90Y absorbed dose in selective internal radiation therapy (SIRT), while post-therapy 90Y bremsstrahlung SPECT may be used to measure the delivered ...
    • Development of Molecularly Targeted Agents and Immunotherapies in Glioblastoma: A Personalized Approach. 

      Coleman, N; Ameratunga, M; Lopez, J (2018-01)
      Over the past decade, precision cancer medicine has driven major advances in the management of advanced solid tumours with the identification and targeting of putative driver aberrations transforming the clinical outcomes ...
    • Development of molecularly targeted agents and immunotherapies in small cell lung cancer. 

      Sharp, A; Bhosle, J; Abdelraouf, F; Popat, S; O'Brien, M; Yap, TA (2016-06)
      Small cell lung cancer (SCLC) is a smoking-induced malignancy with multiple toxin-associated mutations, which accounts for 15% of all lung cancers. It remains a clinical challenge with a rapid doubling time, early dissemination ...
    • Development of patient-specific molecular imaging phantoms using a 3D printer. 

      Gear, JI; Long, C; Rushforth, D; Chittenden, SJ; Cummings, C; Flux, GD (2014-08)
      Purpose The aim of the study was to investigate rapid prototyping technology for the production of patient-specific, cost-effective liquid fillable phantoms directly from patient CT data.Methods Liver, spleen, and kidney ...
    • Development of PDT/PET Theranostics: Synthesis and Biological Evaluation of an F-18-Radiolabeled Water-Soluble Porphyrin 

      Entract, GM; Bryden, F; Domarkas, J; Savoie, H; Allott, L; Archibald, SJ; Cawthorne, C; Boyle, RW (AMER CHEMICAL SOC, 2015-12)
      Synthesis of the first water-soluble porphyrin radiolabeled with fluorine-18 is described: a new molecular theranostic agent which integrates the therapeutic selectivity of photodynamic therapy (PDT) with the imaging ...
    • Development of research priorities in paediatric pain and palliative care 

      Liossi, C; Anderson, A-K; Howard, RF (SAGE Publications, 2017-02)
      <jats:p> Priority setting for healthcare research is as important as conducting the research itself because rigorous and systematic processes of priority setting can make an important contribution to the quality of research. ...
    • Development of synchronous VHL syndrome tumors reveals contingencies and constraints to tumor evolution. 

      Fisher, R; Horswell, S; Rowan, A; Salm, MP; de Bruin, EC; Gulati, S; McGranahan, N; Stares, M; Gerlinger, M; Varela, I; Crockford, A; Favero, F; Quidville, V; André, F; Navas, C; Grönroos, E; Nicol, D; Hazell, S; Hrouda, D; O'Brien, T; Matthews, N; Phillimore, B; Begum, S; Rabinowitz, A; Biggs, J; Bates, PA; McDonald, NQ; Stamp, G; Spencer-Dene, B; Hsieh, JJ; Xu, J; Pickering, L; Gore, M; Larkin, J; Swanton, C (2014-08-27)
      Background Genomic analysis of multi-focal renal cell carcinomas from an individual with a germline VHL mutation offers a unique opportunity to study tumor evolution.Results We perform whole exome sequencing on four clear ...
    • Development of the SIOPE DIPG network, registry and imaging repository: a collaborative effort to optimize research into a rare and lethal disease. 

      Veldhuijzen van Zanten, SEM; Baugh, J; Chaney, B; De Jongh, D; Sanchez Aliaga, E; Barkhof, F; Noltes, J; De Wolf, R; Van Dijk, J; Cannarozzo, A; Damen-Korbijn, CM; Lieverst, JA; Colditz, N; Hoffmann, M; Warmuth-Metz, M; Bison, B; Jones, DTW; Sturm, D; Gielen, GH; Jones, C; Hulleman, E; Calmon, R; Castel, D; Varlet, P; Giraud, G; Slavc, I; Van Gool, S; Jacobs, S; Jadrijevic-Cvrlje, F; Sumerauer, D; Nysom, K; Pentikainen, V; Kivivuori, S-M; Leblond, P; Entz-Werle, N; von Bueren, AO; Kattamis, A; Hargrave, DR; Hauser, P; Garami, M; Thorarinsdottir, HK; Pears, J; Gandola, L; Rutkauskiene, G; Janssens, GO; Torsvik, IK; Perek-Polnik, M; Gil-da-Costa, MJ; Zheludkova, O; Shats, L; Deak, L; Kitanovski, L; Cruz, O; Morales La Madrid, A; Holm, S; Gerber, N; Kebudi, R; Grundy, R; Lopez-Aguilar, E; Zapata-Tarres, M; Emmerik, J; Hayden, T; Bailey, S; Biassoni, V; Massimino, M; Grill, J; Vandertop, WP; Kaspers, GJL; Fouladi, M; Kramm, CM; van Vuurden, DG; members of the SIOPE DIPG Network (2017-04)
      Diffuse intrinsic pontine glioma (DIPG) is a rare and deadly childhood malignancy. After 40 years of mostly single-center, often non-randomized trials with variable patient inclusions, there has been no improvement in ...
    • Development Refractoriness of MLL-Rearranged Human B Cell Acute Leukemias to Reprogramming into Pluripotency. 

      Muñoz-López, A; Romero-Moya, D; Prieto, C; Ramos-Mejía, V; Agraz-Doblas, A; Varela, I; Buschbeck, M; Palau, A; Carvajal-Vergara, X; Giorgetti, A; Ford, A; Lako, M; Granada, I; Ruiz-Xivillé, N; Rodríguez-Perales, S; Torres-Ruíz, R; Stam, RW; Fuster, JL; Fraga, MF; Nakanishi, M; Cazzaniga, G; Bardini, M; Cobo, I; Bayon, GF; Fernandez, AF; Bueno, C; Menendez, P (2016-10)
      Induced pluripotent stem cells (iPSCs) are a powerful tool for disease modeling. They are routinely generated from healthy donors and patients from multiple cell types at different developmental stages. However, reprogramming ...
    • Developmental markers of B cells are superior to those of T cells for identification of stages with distinct gene expression profiles 

      Hoffmann, R; Seidl, T; Bruno, L; Dugas, M (FEDERATION AMER SOC EXP BIOL, 2003-10)
      B and T lymphocytes develop through a series of cellular stages, which are defined by recombination status of the immunoglobulin and T cell receptor loci and can be separated by analysis of cell-surface markers. We evaluated ...
    • Diagnosis and Diagnostic Imaging of Anal Canal Cancer. 

      Ciombor, KK; Ernst, RD; Brown, G (2017-01)
      Anal canal cancer is an uncommon malignancy but one that is often curable with optimal therapy. Owing to its unique location, histology, risk factors, and usual presentation, a careful diagnostic approach is warranted. ...
    • Diagnosis and management of tropomyosin receptor kinase (TRK) fusion sarcomas: expert recommendations from the World Sarcoma Network. 

      Demetri, GD; Antonescu, CR; Bjerkehagen, B; Bovée, JVMG; Boye, K; Chacón, M; Dei Tos, AP; Desai, J; Fletcher, JA; Gelderblom, H; George, S; Gronchi, A; Haas, RL; Hindi, N; Hohenberger, P; Joensuu, H; Jones, RL; Judson, I; Kang, Y-K; Kawai, A; Lazar, AJ; Le Cesne, A; Maestro, R; Maki, RG; Martín, J; Patel, S; Penault-Llorca, F; Premanand Raut, C; Rutkowski, P; Safwat, A; Sbaraglia, M; Schaefer, I-M; Shen, L; Serrano, C; Schöffski, P; Stacchiotti, S; Sundby Hall, K; Tap, WD; Thomas, DM; Trent, J; Valverde, C; van der Graaf, WTA; von Mehren, M; Wagner, A; Wardelmann, E; Naito, Y; Zalcberg, J; Blay, J-Y (2020-11)
      Sarcomas are a heterogeneous group of malignancies with mesenchymal lineage differentiation. The discovery of neurotrophic tyrosine receptor kinase (NTRK) gene fusions as tissue-agnostic oncogenic drivers has led to new ...
    • Diagnosis of digestive system tumours. 

      Washington, MK; Goldberg, RM; Chang, GJ; Limburg, P; Lam, AK; Salto-Tellez, M; Arends, MJ; Nagtegaal, ID; Klimstra, DS; Rugge, M; Schirmacher, P; Lazar, AJ; Odze, RD; Carneiro, F; Fukayama, M; Cree, IA; WHO Classification of Tumours Editorial Board (2021-03)
      The WHO Classification of Tumours provides the international standards for the classification and diagnosis of tumours. It enables direct comparisons to be made between different countries. In the new fifth edition, the ...
    • Diagnostic Accuracy and Safety of Coaxial System in Oncology Patients Treated in a Specialist Cancer Center With Prospective Validation Within Clinical Trial Data. 

      Khan, K; Gonzalez-Exposito, R; Cunningham, D; Koh, D-M; Woolston, A; Barber, L; Griffiths, B; Kouvelakis, K; Calamai, V; Bali, M; Khan, N; Bryant, A; Saffery, C; Dearman, C; Begum, R; Rao, S; Starling, N; Watkins, D; Chau, I; Braconi, C; Valeri, N; Gerlinger, M; Fotiadis, N (2020-01)
      Background Image-guided tissue biopsies are critically important in the diagnosis and management of cancer patients. High-yield samples are also vital for biomarker and resistance mechanism discovery through molecular/genomic ...
    • Diagnostic accuracy of deep learning in medical imaging: a systematic review and meta-analysis. 

      Aggarwal, R; Sounderajah, V; Martin, G; Ting, DSW; Karthikesalingam, A; King, D; Ashrafian, H; Darzi, A (2021-04-07)
      Deep learning (DL) has the potential to transform medical diagnostics. However, the diagnostic accuracy of DL is uncertain. Our aim was to evaluate the diagnostic accuracy of DL algorithms to identify pathology in medical ...
    • Diagnostic accuracy of high-resolution MRI as a method to predict potentially safe endoscopic and surgical planes in patients with early rectal cancer. 

      Balyasnikova, S; Read, J; Wotherspoon, A; Rasheed, S; Tekkis, P; Tait, D; Cunningham, D; Brown, G (2017-01)
      Early rectal cancer (ERC) assessment should include prediction of the potential excision plane to safely remove lesions with clear deep margins and feasibility of organ preservation.MRI accuracy for differentiating ≤T1sm2 ...