Now showing items 1974-1993 of 4640

    • Homeobox B13 G84E Mutation and Prostate Cancer Risk. 

      Nyberg, T; Govindasami, K; Leslie, G; Dadaev, T; Bancroft, E; Ni Raghallaigh, H; Brook, MN; Hussain, N; Keating, D; Lee, A; McMahon, R; Morgan, A; Mullen, A; Osborne, A; Rageevakumar, R; UK Genetic Prostate Cancer Study Collaborators; Kote-Jarai, Z; Eeles, R; Antoniou, AC (2019-05)
      Background The homeobox B13 (HOXB13) G84E mutation has been recommended for use in genetic counselling for prostate cancer (PCa), but the magnitude of PCa risk conferred by this mutation is uncertain.Objective To obtain ...
    • Homologous recombination DNA repair deficiency and PARP inhibition activity in primary triple negative breast cancer. 

      Chopra, N; Tovey, H; Pearson, A; Cutts, R; Toms, C; Proszek, P; Hubank, M; Dowsett, M; Dodson, A; Daley, F; Kriplani, D; Gevensleben, H; Davies, HR; Degasperi, A; Roylance, R; Chan, S; Tutt, A; Skene, A; Evans, A; Bliss, JM; Nik-Zainal, S; Turner, NC (2020-05-29)
      Triple negative breast cancer (TNBC) encompasses molecularly different subgroups, with a subgroup harboring evidence of defective homologous recombination (HR) DNA repair. Here, within a phase 2 window clinical trial, RIO ...
    • Horizon scanning for novel therapeutics for the treatment of prostate cancer. 

      Bianchini, D; Zivi, A; Sandhu, S; de Bono, JS (2010-10)
      Treatment options for patients with advanced prostate cancer (PCa) remain limited. Improved understanding of the underlying molecular drivers of PCa pathogenesis, progression and resistance development has provided the ...
    • Hotspot SF3B1 mutations induce metabolic reprogramming and vulnerability to serine deprivation. 

      Dalton, WB; Helmenstine, E; Walsh, N; Gondek, LP; Kelkar, DS; Read, A; Natrajan, R; Christenson, ES; Roman, B; Das, S; Zhao, L; Leone, RD; Shinn, D; Groginski, T; Madugundu, AK; Patil, A; Zabransky, DJ; Medford, A; Lee, J; Cole, AJ; Rosen, M; Thakar, M; Ambinder, A; Donaldson, J; DeZern, AE; Cravero, K; Chu, D; Madero-Marroquin, R; Pandey, A; Hurley, PJ; Lauring, J; Park, BH (2019-08-08)
      Cancer-associated mutations in the spliceosome gene SF3B1 create a neomorphic protein that produces aberrant mRNA splicing in hundreds of genes, but the ensuing biologic and therapeutic consequences of this missplicing are ...
    • How clinical imaging can assess cancer biology. 

      García-Figueiras, R; Baleato-González, S; Padhani, AR; Luna-Alcalá, A; Vallejo-Casas, JA; Sala, E; Vilanova, JC; Koh, D-M; Herranz-Carnero, M; Vargas, HA (2019-03-04)
      Human cancers represent complex structures, which display substantial inter- and intratumor heterogeneity in their genetic expression and phenotypic features. However, cancers usually exhibit characteristic structural, ...
    • How clinical practice is changing the rules: the sunitinib 2/1 schedule in metastatic renal cell carcinoma. 

      Bracarda, S; Negrier, S; Casper, J; Porta, C; Schmidinger, M; Larkin, J; Gross Goupil, M; Escudier, B (2017-03)
      Introduction Currently, sunitinib is a standard of care in first-line treatment for metastatic renal cell carcinoma (mRCC). However, with the standard 4/2 schedule (sunitinib 50 mg/day; 4 consecutive weeks on treatment; ...
    • How I treat prolymphocytic leukemia 

      Dearden, Claire (2012-07)
      T- and B-cell subtypes of prolymphocytic leukemia (PLL) are rare, aggressive lymphoid malignancies with characteristic morphologic, immunophenotypic, cytogenetic, and molecular features. Recent studies have highlighted the ...
    • How informed is declared altruism in clinical trials? A qualitative interview study of patient decision-making about the QUEST trials (Quality of Life after Mastectomy and Breast Reconstruction). 

      Bidad, N; MacDonald, L; Winters, ZE; Edwards, SJL; Emson, M; Griffin, CL; Bliss, J; Horne, R (2016-09-02)
      Background Randomised controlled trials (RCTs) often fail to recruit sufficient participants, despite altruism being cited as their motivation. Previous investigations of factors influencing participation decisions have ...
    • How RhoGEFs drive triple negative breast cancer cell invasion through the activation of YAP and TAZ 

      Pascual Vargas, P (2020-03-31)
      Dynamical remodelling of the cytoskeleton is essential for triple negative breast cancer metastasis (TNBC). Cell shape is regulated by RhoGEFs which activate Rho GTPases resulting in changes in actin polymerisation, ...
    • How Should Imaging Direct/Orient Management of Rectal Cancer? 

      Bhoday, J; Balyasnikova, S; Wale, A; Brown, G (2017-11-27)
      Modern rectal cancer management is dependent on preoperative staging, and radiological assessment is a crucial part of this process. Imaging must provide sufficient information to guide preoperative decision-making that ...
    • How to build an effective research network: lessons from two decades of the GARNet plant science community. 

      Parry, G; Benitez-Alfonso, Y; Gibbs, DJ; Grant, M; Harper, A; Harrison, CJ; Kaiserli, E; Leonelli, S; May, S; McKim, S; Spoel, S; Turnbull, C; van der Hoorn, RAL; Murray, J
      Successful collaborative research is dependent on excellent ideas and innovative experimental approaches, as well as the provision of appropriate support networks. Collaboration requires venues, infrastructures, training ...
    • How to design a dose-finding study using the continual reassessment method. 

      Wheeler, GM; Mander, AP; Bedding, A; Brock, K; Cornelius, V; Grieve, AP; Jaki, T; Love, SB; Odondi, L; Weir, CJ; Yap, C; Bond, SJ (2019-01-18)
      Introduction The continual reassessment method (CRM) is a model-based design for phase I trials, which aims to find the maximum tolerated dose (MTD) of a new therapy. The CRM has been shown to be more accurate in targeting ...
    • How to develop a meaningful radiomic signature for clinical use in oncologic patients. 

      Papanikolaou, N; Matos, C; Koh, DM (2020-05)
      During the last decade, there is an increasing usage of quantitative methods in Radiology in an effort to reduce the diagnostic variability associated with a subjective manner of radiological interpretation. Combined ...
    • HOX genes promote cell proliferation and are potential therapeutic targets in adrenocortical tumours. 

      Francis, JC; Gardiner, JR; Renaud, Y; Chauhan, R; Weinstein, Y; Gomez-Sanchez, C; Lefrançois-Martinez, A-M; Bertherat, J; Val, P; Swain, A (2020-11-20)
      Background Understanding the pathways that drive adrenocortical carcinoma (ACC) is essential to the development of more effective therapies. This study investigates the role of the transcription factor HOXB9 and other HOX ...
    • HPV testing as a triage for borderline or mild dyskaryosis on cervical cytology: results from the Sentinel Sites study 

      Kelly, RS; Patnick, J; Kitchener, HC; Moss, SM; Grp, NHSCSPHPVSI (NATURE PUBLISHING GROUP, 2011-09-27)
      BACKGROUND: Earlier pilot studies of human papillomavirus (HPV) triage concluded that HPV triage was feasible and cost-effective. The aim of the present study was to study the impact of wider rollout of HPV triage for women ...
    • HPV testing in combination with liquid-based cytology in primary cervical screening (ARTISTIC): a randomised controlled trial 

      Kitchener, HC; Almonte, M; Thomson, C; Wheeler, P; Sargent, A; Stoykova, B; Gilham, C; Baysson, H; Roberts, C; Dowie, R; Desai, M; Mather, J; Bailey, A; Turner, A; Moss, S; Peto, J (ELSEVIER SCIENCE INC, 2009-07)
      Background Testing for human papillomavirus (HPV) DNA is reportedly more sensitive than cytology for the detection of high-grade cervical intraepithelial neoplasia (CIN). The effectiveness of HPV testing in primary cervical ...
    • HPV testing in routine cervical screening: cross sectional data from the ARTISTIC trial 

      Kitchener, HC; Almonte, M; Wheeler, P; Desai, M; Gilham, C; Bailey, A; Sargent, A; Peto, J; Grp, ATS (NATURE PUBLISHING GROUP, 2006-07-03)
      To evaluate the effectiveness of human papillomavirus (HPV) testing in primary cervical screening. This was a cross-sectional study from the recruitment phase of a prospective randomised trial. Women were screened for HPV ...
    • HPV-Related Oropharynx Cancer in the United Kingdom: An Evolution in the Understanding of Disease Etiology. 

      Schache, AG; Powell, NG; Cuschieri, KS; Robinson, M; Leary, S; Mehanna, H; Rapozo, D; Long, A; Cubie, H; Junor, E; Monaghan, H; Harrington, KJ; Nutting, CM; Schick, U; Lau, AS; Upile, N; Sheard, J; Brougham, K; West, CML; Oguejiofor, K; Thomas, S; Ness, AR; Pring, M; Thomas, GJ; King, EV; McCance, DJ; James, JA; Moran, M; Sloan, P; Shaw, RJ; Evans, M; Jones, TM (2016-11)
      A rising incidence of oropharyngeal squamous cell carcinoma (OPSCC) incidence has occurred throughout the developed world, where it has been attributed to an increasing impact of human papillomavirus (HPV) on disease ...
    • HRDetect is a predictor of BRCA1 and BRCA2 deficiency based on mutational signatures. 

      Davies, H; Glodzik, D; Morganella, S; Yates, LR; Staaf, J; Zou, X; Ramakrishna, M; Martin, S; Boyault, S; Sieuwerts, AM; Simpson, PT; King, TA; Raine, K; Eyfjord, JE; Kong, G; Borg, Å; Birney, E; Stunnenberg, HG; van de Vijver, MJ; Børresen-Dale, A-L; Martens, JWM; Span, PN; Lakhani, SR; Vincent-Salomon, A; Sotiriou, C; Tutt, A; Thompson, AM; Van Laere, S; Richardson, AL; Viari, A; Campbell, PJ; Stratton, MR; Nik-Zainal, S (2017-04)
      Approximately 1-5% of breast cancers are attributed to inherited mutations in BRCA1 or BRCA2 and are selectively sensitive to poly(ADP-ribose) polymerase (PARP) inhibitors. In other cancer types, germline and/or somatic ...
    • HSF1 Is Essential for Myeloma Cell Survival and A Promising Therapeutic Target. 

      Fok, JHL; Hedayat, S; Zhang, L; Aronson, LI; Mirabella, F; Pawlyn, C; Bright, MD; Wardell, CP; Keats, JJ; De Billy, E; Rye, CS; Chessum, NEA; Jones, K; Morgan, GJ; Eccles, SA; Workman, P; Davies, FE (2018-05)
      Purpose: Myeloma is a plasma cell malignancy characterized by the overproduction of immunoglobulin, and is therefore susceptible to therapies targeting protein homeostasis. We hypothesized that heat shock factor 1 (HSF1) ...