Now showing items 4209-4228 of 4652

    • The influence of life stage on supportive care and information needs in cancer patients: does older age matter? 

      Watson, M; Davolls, S; Mohammed, K; Shepherd, S (SPRINGER, 2015-10)
      The purpose of this study is to clarify the effect of older age, on supportive care needs, information satisfaction and service needs in the year following a cancer diagnosis. Primary or recurrent prostate, breast, lung ...
    • The influence of obesity-related factors in the etiology of renal cell carcinoma-A mendelian randomization study. 

      Johansson, M; Carreras-Torres, R; Scelo, G; Purdue, MP; Mariosa, D; Muller, DC; Timpson, NJ; Haycock, PC; Brown, KM; Wang, Z; Ye, Y; Hofmann, JN; Foll, M; Gaborieau, V; Machiela, MJ; Colli, LM; Li, P; Garnier, J-G; Blanche, H; Boland, A; Burdette, L; Prokhortchouk, E; Skryabin, KG; Yeager, M; Radojevic-Skodric, S; Ognjanovic, S; Foretova, L; Holcatova, I; Janout, V; Mates, D; Mukeriya, A; Rascu, S; Zaridze, D; Bencko, V; Cybulski, C; Fabianova, E; Jinga, V; Lissowska, J; Lubinski, J; Navratilova, M; Rudnai, P; Benhamou, S; Cancel-Tassin, G; Cussenot, O; Weiderpass, E; Ljungberg, B; Tumkur Sitaram, R; Häggström, C; Bruinsma, F; Jordan, SJ; Severi, G; Winship, I; Hveem, K; Vatten, LJ; Fletcher, T; Larsson, SC; Wolk, A; Banks, RE; Selby, PJ; Easton, DF; Andreotti, G; Beane Freeman, LE; Koutros, S; Männistö, S; Weinstein, S; Clark, PE; Edwards, TL; Lipworth, L; Gapstur, SM; Stevens, VL; Carol, H; Freedman, ML; Pomerantz, MM; Cho, E; Wilson, KM; Gaziano, JM; Sesso, HD; Freedman, ND; Parker, AS; Eckel-Passow, JE; Huang, W-Y; Kahnoski, RJ; Lane, BR; Noyes, SL; Petillo, D; Teh, BT; Peters, U; White, E; Anderson, GL; Johnson, L; Luo, J; Buring, J; Lee, I-M; Chow, W-H; Moore, LE; Eisen, T; Henrion, M; Larkin, J; Barman, P; Leibovich, BC; Choueiri, TK; Lathrop, GM; Deleuze, J-F; Gunter, M; McKay, JD; Wu, X; Houlston, RS; Chanock, SJ; Relton, C; Richards, JB; Martin, RM; Davey Smith, G; Brennan, P (2019-01-03)
      Background Several obesity-related factors have been associated with renal cell carcinoma (RCC), but it is unclear which individual factors directly influence risk. We addressed this question using genetic markers as proxies ...
    • The initiation of breast and prostate cancer 

      Grover, PL; Martin, FL (2002-07)
      The agents responsible for the initiation of human mammary and prostatic cancers remain unidentified. Population migration studies on breast and prostate cancer risk have revealed that incidence rates in migrants from ...
    • The integration of BRCA testing into oncology clinics. 

      Percival, N; George, A; Gyertson, J; Hamill, M; Fernandes, A; Davies, E; Rahman, N; Banerjee, S (2016-06)
      Purpose The PARP inhibitor, Olaparib, is approved for women with BRCA-mutated ovarian cancer. Therefore there is an urgent need to test patients and obtain results in time to influence treatment. Models of BRCA testing, ...
    • The integration of docetaxel into first-line chemotherapy for ovarian cancer. 

      Kaye, SB; Scottish Gynaecological Cancer Trials Group (2001-01)
      Docetaxel is being explored as an alternative to paclitaxel in the treatment of ovarian cancer for several reasons: a) evidence of superiority in preclinical models; b) at least comparable activity in platinum-refractory ...
    • The Intensity-Modulated Pelvic Node and Bladder Radiotherapy (IMPART) Trial: A Phase II Single-Centre Prospective Study. 

      Tan, MP; Harris, V; Warren-Oseni, K; McDonald, F; McNair, H; Taylor, H; Hansen, V; Sharabiani, M; Thomas, K; Jones, K; Dearnaley, D; Hafeez, S; Huddart, RA (2020-02)
      Aims Node-positive bladder cancer (NPBC) carries a poor prognosis and has traditionally been treated palliatively. However, surgical series suggest that a subset of NPBC patients can achieve long-term control after cystectomy ...
    • The inter-ring arrangement of the cytosolic chaperonin CCT 

      Martín-Benito, J; Grantham, J; Boskovic, J; Brackley, KI; Carrascosa, JL; Willison, KR; Valpuesta, JM (2007-03)
      The eukaryotic cytosolic chaperonin CCT (chaperonin containing TCP-1) is the most complex of all chaperonins—an oligomeric structure built from two identical rings, each composed of single copies of eight different subunits. ...
    • The Interacting Head Motif Structure Does Not Explain the X-Ray Diffraction Patterns in Relaxed Vertebrate (Bony Fish) Skeletal Muscle and Insect (<i>Lethocerus</i>) Flight Muscle. 

      Knupp, C; Morris, E; Squire, JM (2019-09-14)
      Unlike electron microscopy, which can achieve very high resolution but to date can only be used to study static structures, time-resolved X-ray diffraction from contracting muscles can, in principle, be used to follow the ...
    • The interaction network of the chaperonin CCT 

      Dekker, C; Stirling, PC; McCormack, EA; Filmore, H; Paul, A; Brost, RL; Costanzo, M; Boone, C; Leroux, MR; Willison, KR (NATURE PUBLISHING GROUP, 2008-07-09)
      The eukaryotic cytosolic chaperonin containing TCP-1 (CCT) has an important function in maintaining cellular homoeostasis by assisting the folding of many proteins, including the cytoskeletal components actin and tubulin. ...
    • The intermediate-activity (L597V)BRAF mutant acts as an epistatic modifier of oncogenic RAS by enhancing signaling through the RAF/MEK/ERK pathway 

      Andreadi, C; Cheung, L-K; Giblett, S; Patel, B; Jin, H; Mercer, K; Kamata, T; Lee, P; Williams, A; McMahon, M; Marais, R; Pritchard, C (COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT, 2012-09-01)
      (L597V)BRAF mutations are acquired somatically in human cancer samples and are frequently coincident with RAS mutations. Germline (L597V)BRAF mutations are also found in several autosomal dominant developmental conditions ...
    • The International Penile Advanced Cancer Trial (InPACT): Rationale and Current Status 

      Canter, DJ; Nicholson, S; Watkin, N; Hall, E; Pettaway, C (Elsevier BV, 2019-06)
    • The Intracranial Distribution of Gliomas in Relation to Exposure From Mobile Phones: Analyses From the INTERPHONE Study. 

      Grell, K; Frederiksen, K; Schüz, J; Cardis, E; Armstrong, B; Siemiatycki, J; Krewski, DR; McBride, ML; Johansen, C; Auvinen, A; Hours, M; Blettner, M; Sadetzki, S; Lagorio, S; Yamaguchi, N; Woodward, A; Tynes, T; Feychting, M; Fleming, SJ; Swerdlow, AJ; Andersen, PK (2016-12)
      When investigating the association between brain tumors and use of mobile telephones, accurate data on tumor position are essential, due to the highly localized absorption of energy in the human brain from the radio-frequency ...
    • The kinase polypharmacology landscape of clinical PARP inhibitors. 

      Antolin, AA; Ameratunga, M; Banerji, U; Clarke, PA; Workman, P; Al-Lazikani, B (2020-02-17)
      Polypharmacology plays an important role in defining response and adverse effects of drugs. For some mechanisms, experimentally mapping polypharmacology is commonplace, although this is typically done within the same protein ...
    • The Ku-binding motif is a conserved module for recruitment and stimulation of non-homologous end-joining proteins. 

      Grundy, GJ; Rulten, SL; Arribas-Bosacoma, R; Davidson, K; Kozik, Z; Oliver, AW; Pearl, LH; Caldecott, KW (2016-04-11)
      The Ku-binding motif (KBM) is a short peptide module first identified in APLF that we now show is also present in Werner syndrome protein (WRN) and in Modulator of retrovirus infection homologue (MRI). We also identify a ...
    • The landscape of RNA polymerase II-associated chromatin interactions in prostate cancer. 

      Ramanand, SG; Chen, Y; Yuan, J; Daescu, K; Lambros, MB; Houlahan, KE; Carreira, S; Yuan, W; Baek, G; Sharp, A; Paschalis, A; Kanchwala, M; Gao, Y; Aslam, A; Safdar, N; Zhan, X; Raj, GV; Xing, C; Boutros, PC; de Bono, J; Zhang, MQ; Mani, RS (2020-08)
      Transcriptional dysregulation is a hallmark of prostate cancer (PCa). We mapped the RNA polymerase II-associated (RNA Pol II-associated) chromatin interactions in normal prostate cells and PCa cells. We discovered thousands ...
    • The landscape of tyrosine kinase inhibitors in sarcomas: looking beyond pazopanib. 

      Wilding, CP; Elms, ML; Judson, I; Tan, A-C; Jones, RL; Huang, PH (2019-11-13)
      Introduction: Tyrosine kinases are key mediators of intracellular signaling cascades and aberrations in these proteins have been implicated in driving oncogenesis through the dysregulation of fundamental cellular processes ...
    • The Lineage Determining Factor GRHL2 Collaborates with FOXA1 to Establish a Targetable Pathway in Endocrine Therapy-Resistant Breast Cancer. 

      Cocce, KJ; Jasper, JS; Desautels, TK; Everett, L; Wardell, S; Westerling, T; Baldi, R; Wright, TM; Tavares, K; Yllanes, A; Bae, Y; Blitzer, JT; Logsdon, C; Rakiec, DP; Ruddy, DA; Jiang, T; Broadwater, G; Hyslop, T; Hall, A; Laine, M; Phung, L; Greene, GL; Martin, L-A; Pancholi, S; Dowsett, M; Detre, S; Marks, JR; Crawford, GE; Brown, M; Norris, JD; Chang, C-Y; McDonnell, DP (2019-10)
      Notwithstanding the positive clinical impact of endocrine therapies in estrogen receptor-alpha (ERα)-positive breast cancer, de novo and acquired resistance limits the therapeutic lifespan of existing drugs. Taking the ...
    • The long non-coding RNA <i>HOTAIR</i> is transcriptionally activated by HOXA9 and is an independent prognostic marker in patients with malignant glioma. 

      Xavier-Magalhães, A; Gonçalves, CS; Fogli, A; Lourenço, T; Pojo, M; Pereira, B; Rocha, M; Lopes, MC; Crespo, I; Rebelo, O; Tão, H; Lima, J; Moreira, R; Pinto, AA; Jones, C; Reis, RM; Costello, JF; Arnaud, P; Sousa, N; Costa, BM (2018-03)
      The lncRNA <i>HOTAIR</i> has been implicated in several human cancers. Here, we evaluated the molecular alterations and upstream regulatory mechanisms of <i>HOTAIR</i> in glioma, the most common primary brain tumors, and ...
    • The long non-coding RNA MYCNOS-01 regulates MYCN protein levels and affects growth of MYCN-amplified rhabdomyosarcoma and neuroblastoma cells. 

      O'Brien, EM; Selfe, JL; Martins, AS; Walters, ZS; Shipley, JM (2018-02-21)
      MYCN is amplified in small cell lung cancers and several pediatric tumors, including alveolar rhabdomyosarcomas and neuroblastomas. MYCN protein is known to play a key oncogenic role in both alveolar rhabdomyosarcomas and ...