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Now showing items 1-20 of 5449
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Rheo-optics of concentrated kaolinite suspensions
(ELSEVIER SCIENCE BV, 1996-06-14) -
Self-assessment of morbidity following radical hysterectomy for cervical cancer.
(1999-03)The aim of this study was to assess the magnitude of the morbidity following radical surgery for early stage cervical cancer. We performed a retrospective survey of all women who had undergone a radical hysterectomy and ... -
Cyclin D1 by flow cytometry as a useful tool in the diagnosis of B-cell malignancies
(2001)The translocation (11;14)(q13;q32) and its molecular counterpart the BCL-1 rearrangement are features observed in mantle cell lymphoma (MCL) and less commonly in other B-cell disorders. This rearrangement leads to cyclin ... -
The case against apoptosis
(INFORMA HEALTHCARE, 2001)Apoptosis is not as dominant a process in cell loss from normal tissues and tumours as has sometimes been claimed. The term ‘programmed cell death’, which many authors regard as synonymous with apoptosis, is an unsatisfactory ... -
6p abnormalities and TNF-α over-expression in retinoblastoma cell line
(2001)Retinoblastoma is the most common primary intra-ocular tumor in childhood. It has been established that recurrent cytogenetic abnormalities are the hallmark of mostly all malignant tumors. Recurrent atypical cytogenetic ... -
Mutational Screen Identifies Critical Amino Acid Residues of β-Actin Mediating Interaction between Its Folding Intermediates and Eukaryotic Cytosolic Chaperonin CCT
(2001)Thethree-dimensional reconstruction of apo-CCT-α-actin by cryoelectron microscopy shows that actin binds either the CCTβ–CCTδ or the CCTϵ–CCTδ subunit pairs of the chaperonin in an open and apparently quasi-native conformation. ... -
Morphological transformation of C3H/M2 mouse fibroblasts by, and genotoxicity of, extracts of human milk
(2001)Breast cancer may be initiated by environmental/dietary agents and human milk may act as an ex vivo indicator of in vivo exposure of mammary epithelial cells to genotoxins. Extracts of human milk from UK-resident women ... -
GTI-2040 lorus therapeutics
(2001) -
DNA minor-groove recognition by small molecules
(ROYAL SOC CHEMISTRY, 2001) -
PAX3-FKHR Induces Morphological Change and Enhances Cellular Proliferation and Invasion in Rhabdomyosarcoma
(2001)Alveolar rhabdomyosarcoma (ARMS) is consistently associated with the characteristic translocations t(2;13)(q35;q14) and t(1;13)(p36;q14), which encode for the PAX3-FKHR and PAX7-FKHR fusion oncoproteins respectively. We ... -
Radiotherapy for brain metastases
(SPRINGER-VERLAG LONDON LTD, 2001) -
The BAH domain, polybromo and the RSC chromatin remodelling complex
(2001)The BAH (Bromo-adjacent homology) domain is a domain first identified in the vertebrate polybromo protein, a protein present in a large nuclear complex. Polybromo has two BAH domains, six bromodomains and an HMG-box. The ... -
Treatment strategies for metastatic Ewing’s sarcoma
(2001)Therapy in metastatic Ewing’s sarcoma is reviewed using the methodology recommended by the guidelines project of the Federation of French Cancer Centres (FNCLCC) Standards, Options and Recommendation (SOR) Group. Twelve ... -
Incorporating biologic measurements (SF2, CFE) into a tumor control probability model increases their prognostic significance: a study in cervical carcinoma treated with radiation therapy
(2001)Purpose: To assess whether incorporation of measurements of surviving fraction at 2 Gy (SF2) and colony-forming efficiency (CFE) into a tumor control probability (tcp) model increases their prognostic significance. Methods ... -
Polymer-assisted solution-phase library synthesis of 4-alkoxy-2-hydroxy-3,5,6-trifluorobenzoic acids
(2001)The efficient synthesis of a small library of 4-alkoxy-2-hydroxy-3,5,6-trifluorobenzoic acids is described via the fluoride mediated alkylation of 5,6,8-trifluoro-7-hydroxy-2-methyl-benzo[1,3]dioxin-4-one with a collection ... -
Point Mutations in a Hinge Linking the Small and Large Domains of β-Actin Result in Trapped Folding Intermediates Bound to Cytosolic Chaperonin CCT
(2001)The30-Å cryo-EM-derived structure of apo-CCT–α-actin shows actin opened up across its nucleotide-binding cleft and binding to either of two CCT subunit pairs, CCTβ–CCTδ or CCTϵ–CCTδ, in a similar 1:4 arrangement. The two ... -
Radiation response and cure rate of human colon adenocarcinoma spheroids of different size: the significance of hypoxia on tumor control modelling
(2001)Purpose: To evaluate the adequacy of a Poisson tumor control probability (tcp) model and the impact of hypoxia on tumor cure. Methods and Materials: A human colon adenocarcinoma cell line, WiDr, was grown as multicellular ... -
Analysis of the Interaction between the Eukaryotic Chaperonin CCT and Its Substrates Actin and Tubulin
(2001)Twomechanisms have thus far been characterized for the assistance by chaperonins of the folding of other proteins. The first and best described is that of the prokaryotic chaperonin GroEL, which interacts with a large ...
