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Now showing items 21-40 of 5859
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G-quadruplexes as therapeutic targets
(WILEY-BLACKWELL, 2001)The ends of chromosomes (telomeres) consist of tandem repeats of guanine-rich sequences. In eukaryotics, telomeric DNA is single stranded for the final few hundred bases. These single-stranded sequences can fold into a ... -
The integration of docetaxel into first-line chemotherapy for ovarian cancer.
(2001-01)Docetaxel is being explored as an alternative to paclitaxel in the treatment of ovarian cancer for several reasons: a) evidence of superiority in preclinical models; b) at least comparable activity in platinum-refractory ... -
Minimal residual disease at the time of peripheral blood stem cell harvest in patients with advanced neuroblastoma
(2001-01)Background. Despite treatment with high-dose myeloblative chemotherapy and peripheral blood stem cell (PBSC) rescue, a high proportion of children with neuroblastoma relapse and die. Re-infusion of PBSC contaminated with ... -
Molecular cytogenetic analysis consistently identifies translocations involving chromosomes 1, 2 and 15 in five embryonal rhabdomyosarcoma cell lines and a PAX-FOXO1A fusion gene negative alveolar rhabdomyosarcoma cell line.
(KARGER, 2001-01-01)Rhabdomyosarcoma in children is a "small round blue cell tumour" that displays skeletal muscle differentiation. Two main histological variants are recognised, alveolar (ARMS) and embryonal (ERMS) rhabdomyosarcoma. Whereas ... -
A paradox: urgent BRCA genetic testing.
(Springer Science and Business Media LLC, 2001-01-01)Diagnostic or predictive testing for germline mutations in cancer predisposition genes is inherently slow as result of both genetic counselling and mutation analysis. The overall time taken for mutation testing is not ... -
Morphological transformation of C3H/M2 mouse fibroblasts by, and genotoxicity of, extracts of human milk
(2001-01-01)Breast cancer may be initiated by environmental/dietary agents and human milk may act as an ex vivo indicator of in vivo exposure of mammary epithelial cells to genotoxins. Extracts of human milk from UK-resident women ... -
Differences between blood and liver aromatic DNA adduct formation
(PERGAMON-ELSEVIER SCIENCE LTD, 2001-01-01)Aromatic DNA adducts in the livers and blood of grey mullet (Mugil sp.) have been monitored between 1993 and 1996 by the isolation of DNA and the postlabeling of the DNA adducts with P-32. Th, grey mullet were sampled from ... -
Randomized trial of porcarbazine, lomustine, and vincristine in the adjuvant treatment of high-grade astrocytoma: A medical research council trial
(2001-01-15)Purpose: Meta-analyses of the published literature suggest ct survival benefit to adjuvant chemotherapy for high-grade astrocytoma, which individual sma trials have been unable to demonstrate reliably. The Medical Research ... -
Synthesis and antitumour activity of platinum(II) and platinum(IV) complexes containing ethylenediamine-derived ligands having alcohol, carboxylic acid and acetate substituents - Crystal and molecular structure of [(PtLCl2)-Cl-4]center dot H2O where L-4 is ethylenediamine-N,N ‘-diacetate
(2001-01-15)Several cisplatin analogues of ethylenediamine-derived ligands containing alcohol, carboxylic acid and acetate substituents have been prepared and characterised, Oxidation of some of these square planar platinum(II) complexes ... -
A new class of symmetric bisbenzimidazole-based DNA minor groove-binding agents showing antitumor activity
(2001-01-18)The synthesis and evaluation of the novel head-to-head bisbenzimidazole compound 2,2-bis[4’-(3 “ -dimethylamino- 1 “ -propyloxy)phenyl]-5,5-bi-1H-benzimidazole is described. An X-ray crystallographic study of a complex ... -
PRH represses transcription in hematopoietic cells by at least two independent mechanisms
(2001-01-26)PRH (proline-rich homeodomain protein) is strongly expressed in the hematopoietic compartment, Here we show that PRH is a repressor of transcription in hematopoietic cells. A fragment of PRH that includes the homeodomain ... -
Incorporating dynamic collimator motion in Monte Carlo simulations: an application in modelling a dynamic wedge
(IOP PUBLISHING LTD, 2001-02)In radiation therapy, new treatment modalities employing dynamic collimation and intensity modulation increase the complexity of dose calculation because a new dimension, time, has to be incorporated into the traditional ... -
Single nucleotide polymorphisms, metabolic activation and environmental carcinogenesis: why molecular epidemiologists should think about enzyme expression
(2001-02)This commentary was written to stimulate thoughts on, and consideration of, enzyme expression data in target organs when investigating possible associations between polymorphisms in carcinogen activation enzymes, ... -
Cancer and genomics
(2001-02)Cancer and genomics. Identification of the genes that cause oncogenesis is a central aim of cancer research. We searched the proteins predicted from the draft human genome sequence for paralogues of known tumour suppressor ... -
An ntcp formula for the series model with a Yaes-type functional subunit mechanism
(IOP PUBLISHING LTD, 2001-02)Yaes and Kalend have noted that if functional subunit size is determined by factors such as cell migration lengths or biochemical diffusion lengths, rather than by fixed anatomical boundaries, then the conventional series ... -
Genetic mechanisms in squamous cell carcinoma of the head and neck.
(2001-02)Genetic mechanisms in squamous cell carcinoma of the head and neck. This review aims to explore the genetic mechanisms involved in the development of squamous cell carcinoma of the head and neck (SCCHN). The epidemiology ... -
Nested allosteric interactions in the cytoplasmic chaperonin containing TCP-1
(2001-02)Initial rates of ATP hydrolysis by the chaperonin containing TCP-1 (CCT) from bovine testis were measured as a function of ATP concentration. Two allosteric transitions are observed: one at relatively low concentrations ... -
Congenital alveolar rhabdomyosarcoma - Clinical and molecular distinction from alveolar rhabdomyosarcoma in older children
(2001-02-01)BACKGROUND, Congenital alveolar rhabdomyosarcoma (RMS) is extremely rare and invariably fatal with current therapy. Its clinical presentation is unusual and is distinct from RMS in older children, with > 50% of patients ... -
Multicenter phase II trial of temozolomide in patients with glioblastoma multiforme at first relapse
(KLUWER ACADEMIC PUBL, 2001-02-01)Background: Recurrent glioblastoma multiforme (GBM) is resistant to most therapeutic endeavors, with low response rates and survival rarely exceeding six months. There are no clearly established chemotherapeutic regimens ... -
Design and performance of a data acquisition system for VUB-PET
(Institute of Electrical and Electronics Engineers (IEEE), 2001-02-01)A flexible and high-speed VME-based data acquisition system (DAQ) has been designed to process data from the University of Brussels (VUB) small-animal positron emission tomography (PET) system. The core tasks of the system ...
