Now showing items 1-4 of 4

    • Activation of either ERK1/2 or ERK5 MAP kinase pathways can lead to disruption of the actin cytoskeleton. 

      Barros, JC; Marshall, CJ (2005-04)
      Oncogenic transformation often leads to the disruption of the actin cytoskeleton. Activation of the classical Ras-Raf-MEK1/2-ERK1/2 signalling cascade has been implicated in the effects of oncogenes such as Ras and Src on ...
    • Cyclin B1 is essential for mitosis in mouse embryos, and its nuclear export sets the time for mitosis. 

      Strauss, B; Harrison, A; Coelho, PA; Yata, K; Zernicka-Goetz, M; Pines, J (2018-01)
      There is remarkable redundancy between the Cyclin-Cdk complexes that comprise the cell cycle machinery. None of the mammalian A-, D-, or E-type cyclins are required in development until implantation, and only Cdk1 is ...
    • EGFR feedback-inhibition by Ran-binding protein 6 is disrupted in cancer. 

      Oldrini, B; Hsieh, W-Y; Erdjument-Bromage, H; Codega, P; Carro, MS; Curiel-García, A; Campos, C; Pourmaleki, M; Grommes, C; Vivanco, I; Rohle, D; Bielski, CM; Taylor, BS; Hollmann, TJ; Rosenblum, M; Tempst, P; Blenis, J; Squatrito, M; Mellinghoff, IK (2017-12-11)
      Transport of macromolecules through the nuclear pore by importins and exportins plays a critical role in the spatial regulation of protein activity. How cancer cells co-opt this process to promote tumorigenesis remains ...
    • Systematic Discovery of Short Linear Motifs Decodes Calcineurin Phosphatase Signaling. 

      Wigington, CP; Roy, J; Damle, NP; Yadav, VK; Blikstad, C; Resch, E; Wong, CJ; Mackay, DR; Wang, JT; Krystkowiak, I; Bradburn, DA; Tsekitsidou, E; Hong, SH; Kaderali, MA; Xu, S-L; Stearns, T; Gingras, A-C; Ullman, KS; Ivarsson, Y; Davey, NE; Cyert, MS (2020-07-08)
      Short linear motifs (SLiMs) drive dynamic protein-protein interactions essential for signaling, but sequence degeneracy and low binding affinities make them difficult to identify. We harnessed unbiased systematic approaches ...