Now showing items 1-2 of 2

    • A closed conformation of the Caenorhabditis elegans separase-securin complex. 

      Bachmann, G; Richards, MW; Winter, A; Beuron, F; Morris, E; Bayliss, R (2016-04-13)
      The protease separase plays a key role in sister chromatid disjunction and centriole disengagement. To maintain genomic stability, separase activity is strictly regulated by binding of an inhibitory protein, securin. Despite ...
    • Decreased function of survival motor neuron protein impairs endocytic pathways. 

      Dimitriadi, M; Derdowski, A; Kalloo, G; Maginnis, MS; O'Hern, P; Bliska, B; Sorkaç, A; Nguyen, KCQ; Cook, SJ; Poulogiannis, G; Atwood, WJ; Hall, DH; Hart, AC (2016-07-11)
      Spinal muscular atrophy (SMA) is caused by depletion of the ubiquitously expressed survival motor neuron (SMN) protein, with 1 in 40 Caucasians being heterozygous for a disease allele. SMN is critical for the assembly of ...