Now showing items 1-4 of 4

    • Comprehensive genetic analysis of seven large families with mismatch repair proficient colorectal cancer. 

      Middeldorp, A; Jagmohan-Changur, SC; van der Klift, HM; van Puijenbroek, M; Houwing-Duistermaat, JJ; Webb, E; Houlston, R; Tops, C; Vasen, HFA; Devilee, P; Morreau, H; van Wezel, T; Wijnen, J (2010-06)
      Approximately 40% of colorectal cancer (CRC) families with a diagnosis of hereditary nonpolyposis CRC on the basis of clinical criteria are not a consequence of mismatch repair (MMR) deficiency. Such families provide ...
    • Germline mutations in the PAF1 complex gene CTR9 predispose to Wilms tumour. 

      Hanks, S; Perdeaux, ER; Seal, S; Ruark, E; Mahamdallie, SS; Murray, A; Ramsay, E; Del Vecchio Duarte, S; Zachariou, A; de Souza, B; Warren-Perry, M; Elliott, A; Davidson, A; Price, H; Stiller, C; Pritchard-Jones, K; Rahman, N (2014-08-07)
      Wilms tumour is a childhood kidney cancer. Here we identify inactivating CTR9 mutations in 3 of 35 Wilms tumour families, through exome and Sanger sequencing. By contrast, no similar mutations are present in 1,000 population ...
    • Meta-analysis of five genome-wide association studies identifies multiple new loci associated with testicular germ cell tumor. 

      Wang, Z; McGlynn, KA; Rajpert-De Meyts, E; Bishop, DT; Chung, CC; Dalgaard, MD; Greene, MH; Gupta, R; Grotmol, T; Haugen, TB; Karlsson, R; Litchfield, K; Mitra, N; Nielsen, K; Pyle, LC; Schwartz, SM; Thorsson, V; Vardhanabhuti, S; Wiklund, F; Turnbull, C; Chanock, SJ; Kanetsky, PA; Nathanson, KL; Testicular Cancer Consortium (2017-07)
      The international Testicular Cancer Consortium (TECAC) combined five published genome-wide association studies of testicular germ cell tumor (TGCT; 3,558 cases and 13,970 controls) to identify new susceptibility loci. We ...
    • Second primary cancers in non-Hodgkin lymphoma: Family history and survival. 

      Chattopadhyay, S; Zheng, G; Sud, A; Sundquist, K; Sundquist, J; Försti, A; Houlston, R; Hemminki, A; Hemminki, K (2020-02)
      Second primary cancers (SPCs) account for an increasing proportion of all cancer diagnoses and family history of cancer may be a risk factor for SPCs. Using the Swedish Family-Cancer Database on non-Hodgkin lymphoma (NHL), ...