Now showing items 1-2 of 2

    • A paradox: urgent BRCA genetic testing. 

      Mitchell, G; Ardern-Jones, A; Kissin Mchir, M; Taylor, R; Eeles, RA (2001-01)
      Diagnostic or predictive testing for germline mutations in cancer predisposition genes is inherently slow as result of both genetic counselling and mutation analysis. The overall time taken for mutation testing is not ...
    • Protein-altering germline mutations implicate novel genes related to lung cancer development. 

      Ji, X; Mukherjee, S; Landi, MT; Bosse, Y; Joubert, P; Zhu, D; Gorlov, I; Xiao, X; Han, Y; Gorlova, O; Hung, RJ; Brhane, Y; Carreras-Torres, R; Christiani, DC; Caporaso, N; Johansson, M; Liu, G; Bojesen, SE; Le Marchand, L; Albanes, D; Bickeböller, H; Aldrich, MC; Bush, WS; Tardon, A; Rennert, G; Chen, C; Byun, J; Dragnev, KH; Field, JK; Kiemeney, LF; Lazarus, P; Zienolddiny, S; Lam, S; Schabath, MB; Andrew, AS; Bertazzi, PA; Pesatori, AC; Diao, N; Su, L; Song, L; Zhang, R; Leighl, N; Johansen, JS; Mellemgaard, A; Saliba, W; Haiman, C; Wilkens, L; Fernandez-Somoano, A; Fernandez-Tardon, G; Heijden, EHFMVD; Kim, JH; Davies, MPA; Marcus, MW; Brunnström, H; Manjer, J; Melander, O; Muller, DC; Overvad, K; Trichopoulou, A; Tumino, R; Goodman, GE; Cox, A; Taylor, F; Woll, P; Wichmann, E; Muley, T; Risch, A; Rosenberger, A; Grankvist, K; Johansson, M; Shepherd, F; Tsao, M-S; Arnold, SM; Haura, EB; Bolca, C; Holcatova, I; Janout, V; Kontic, M; Lissowska, J; Mukeria, A; Ognjanovic, S; Orlowski, TM; Scelo, G; Swiatkowska, B; Zaridze, D; Bakke, P; Skaug, V; Butler, LM; Offit, K; Srinivasan, P; Bandlamudi, C; Hellmann, MD; Solit, DB; Robson, ME; Rudin, CM; Stadler, ZK; Taylor, BS; Berger, MF; Houlston, R; McLaughlin, J; Stevens, V; Nickle, DC; Obeidat, M; Timens, W; Artigas, MS; Shete, S; Brenner, H; Chanock, S; Brennan, P; McKay, JD; Amos, CI (2020-05-11)
      Few germline mutations are known to affect lung cancer risk. We performed analyses of rare variants from 39,146 individuals of European ancestry and investigated gene expression levels in 7,773 samples. We find a large-effect ...