Browsing by subject "Magnetic Resonance Imaging"
Now showing items 1-20 of 143
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4D-MRI for thoracic radiotherapy treatment planning and guidance on an MR-linac
Lung cancer currently has a poor prognosis in England and Wales with only 10% of adults surviving five years or more after diagnosis. The poor survival rate demonstrates the need to improve contemporary treatment approaches ... -
Accuracy of classification of invasive lobular carcinoma on needle core biopsy of the breast.
(2016-12)Although the UK National Institute for Health and Care Excellence guidelines recommend that in patients with biopsy-proven invasive lobular carcinoma (ILC), preoperative MRI scan is considered, the accuracy of diagnosis ... -
Accuracy of screening women at familial risk of breast cancer without a known gene mutation: Individual patient data meta-analysis.
(2017-11)<h4>Introduction</h4>Women with a strong family history of breast cancer (BC) and without a known gene mutation have an increased risk of developing BC. We aimed to investigate the accuracy of screening using annual ... -
Acute tumour response to a bispecific Ang-2-VEGF-A antibody: insights from multiparametric MRI and gene expression profiling.
(2016-09)<h4>Background</h4>To assess antivascular effects, and evaluate clinically translatable magnetic resonance imaging (MRI) biomarkers of tumour response in vivo, following treatment with vanucizumab, a bispecific human ... -
Adaptive Radiotherapy Enabled by MRI Guidance.
(2018-11)Adaptive radiotherapy (ART) strategies systematically monitor variations in target and neighbouring structures to inform treatment-plan modification during radiotherapy. This is necessary because a single plan designed ... -
Adjuvant chemotherapy may improve disease-free survival in patients with rectal cancer positive for MRI-detected extramural venous invasion following chemoradiation.
(2017-06)<h4>Aim</h4>MRI-detected extramural venous invasion (mrEMVI) is a poor prognostic factor in rectal cancer. Preoperative chemoradiotherapy (CRT) can cause regression in the severity of EMVI and subsequently improve survival ... -
Alanine dosimetry in strong magnetic fields: use as a transfer standard in MRI-guided radiotherapy.
(2020-06-03)Reference dosimetry in the presence of a strong magnetic field is challenging. Ionisation chambers have shown to be strongly affected by magnetic fields. There is a need for robust and stable detectors in MRI-guided ... -
Antivascular cancer treatments: functional assessments by dynamic contrast-enhanced magnetic resonance imaging.
(2005-05)New anticancer therapeutics that target tumor blood vessels promise improved efficacy and tolerability in humans. Early phase 1 drug trials have shown that the maximum tolerated dose may be inappropriate for more advanced ... -
Assessing response to treatment in breast cancer using magnetic resonance.
(2002-09)Magnetic resonance imaging provides a range of powerful techniques for assessing breast cancer. Contrast enhanced MRI has been shown to provide a sensitive method for assessing primary breast cancer, with increasing emphasis ... -
An audit comparing the reporting of staging MRI scans for rectal cancer with the London Cancer Alliance (LCA) guidelines.
(2017-11)This article focuses on the audit and assessment of clinical practice before and after introduction of MRI reporting guidelines. Standardised proforma based reporting may improve quality of MRI reports. Uptake of the use ... -
Baseline results from the UK SIGNIFY study: a whole-body MRI screening study in TP53 mutation carriers and matched controls.
(2017-07)In the United Kingdom, current screening guidelines for TP53 germline mutation carriers solely recommends annual breast MRI, despite the wide spectrum of malignancies typically seen in this group. This study sought to ... -
Baseline Surveillance in Li-Fraumeni Syndrome Using Whole-Body Magnetic Resonance Imaging: A Meta-analysis.
(2017-12)<h4>Importance</h4>Guidelines for clinical management in Li-Fraumeni syndrome, a multiple-organ cancer predisposition condition, are limited. Whole-body magnetic resonance imaging (WBMRI) may play a role in surveillance ... -
Blood transfusion during radical chemo-radiotherapy does not reduce tumour hypoxia in squamous cell cancer of the head and neck.
(2017-01)<h4>Background</h4>Patients with head and neck squamous cell carcinoma (HNSCC) undergoing radical chemo-radiation (CRT) frequently receive transfusion with packed red cells (PRCT) during radiotherapy on the basis that PRCT ... -
Breast MRI segmentation for density estimation: Do different methods give the same results and how much do differences matter?
(2017-09)<h4>Purpose</h4>To compare two methods of automatic breast segmentation with each other and with manual segmentation in a large subject cohort. To discuss the factors involved in selecting the most appropriate algorithm ... -
Calculation of absorbed dose in radiotherapy by solution of the linear Boltzmann transport equations.
(2019-01-10)Over the last decade, dose calculations which solve the linear Boltzmann transport equations have been introduced into clinical practice and are now in widespread use. However, knowledge in the radiotherapy community ... -
Comparison between MRI and pathology in the assessment of tumour regression grade in rectal cancer.
(2017-11)<h4>Background</h4>Limited data exist regarding the correlation between MRI tumour regression grade (mrTRG) and pathological TRG (pTRG) in rectal cancer.<h4>Methods</h4>mrTRG and pTRG were compared in rectal cancer patients ... -
Comparison of prostate delineation on multimodality imaging for MR-guided radiotherapy.
(2019-03)<h4>Objective:</h4>With increasing incorporation of MRI in radiotherapy, we investigate two MRI sequences for prostate delineation in radiographer-led image guidance.<h4>Methods:</h4>Five therapeutic radiographers contoured ... -
Comparison of six fit algorithms for the intra-voxel incoherent motion model of diffusion-weighted magnetic resonance imaging data of pancreatic cancer patients.
(2018-01)The intravoxel incoherent motion (IVIM) model for diffusion-weighted imaging (DWI) MRI data bears much promise as a tool for visualizing tumours and monitoring treatment response. To improve the currently poor precision ... -
A comparison of the diagnostic value of MRI and <sup>18</sup>F-FDG-PET/CT in suspected spondylodiscitis.
(2017-02)<h4>Purpose</h4>The purpose of this study was to evaluate the diagnostic value of <sup>18</sup>F-fluorodeoxyglucose (FDG) positron emission tomography and computed tomography (PET/CT scan) and magnetic resonance imaging ... -
Comparison of Transrectal Ultrasound Biopsy to Transperineal Template Mapping Biopsies Stratified by Multiparametric Magnetic Resonance Imaging Score in the PROMIS Trial.
(2020-01)<h4>Purpose</h4>We evaluated the performance of transrectal ultrasound guided systematic and transperineal template mapping biopsies with a 5 mm sampling frame stratified by the multiparametric magnetic resonance imaging ...
