Now showing items 1-4 of 4

    • The anticonvulsive Phenhydan<sup>®</sup> suppresses extrinsic cell death. 

      Moerke, C; Jaco, I; Dewitz, C; Müller, T; Jacobsen, AV; Gautheron, J; Fritsch, J; Schmitz, J; Bräsen, JH; Günther, C; Murphy, JM; Kunzendorf, U; Meier, P; Krautwald, S (2019-09)
      Different forms of regulated cell death-like apoptosis and necroptosis contribute to the pathophysiology of clinical conditions including ischemia-reperfusion injury, myocardial infarction, sepsis, and multiple sclerosis. ...
    • The Diversification of Cell Death and Immunity: Memento Mori. 

      Legrand, AJ; Konstantinou, M; Goode, EF; Meier, P (2019-10-02)
      Why do cells have so many ways to die? Why does "cellular suicide" exist at all? In the war against pathogens and rogue cells, organisms developed cellular suicide as a last resort. Fighting an evolutionary arms race, cell ...
    • Ubiquitin-mediated regulation of necroptosis 

      Ramos Garcia, L (2020-01-31)
      Regulated cell death is a fundamental cellular process that is critical for the development and survival of multicellular organisms. Cell death and inflammation are essential to restore tissue homeostasis following tissue ...
    • Ubiquitylation of MLKL at lysine 219 positively regulates necroptosis-induced tissue injury and pathogen clearance. 

      Garcia, LR; Tenev, T; Newman, R; Haich, RO; Liccardi, G; John, SW; Annibaldi, A; Yu, L; Pardo, M; Young, SN; Fitzgibbon, C; Fernando, W; Guppy, N; Kim, H; Liang, L-Y; Lucet, IS; Kueh, A; Roxanis, I; Gazinska, P; Sims, M; Smyth, T; Ward, G; Bertin, J; Beal, AM; Geddes, B; Choudhary, JS; Murphy, JM; Aurelia Ball, K; Upton, JW; Meier, P (2021-06-07)
      Necroptosis is a lytic, inflammatory form of cell death that not only contributes to pathogen clearance but can also lead to disease pathogenesis. Necroptosis is triggered by RIPK3-mediated phosphorylation of MLKL, which ...