Now showing items 1-3 of 3

    • Signalling pathways implicated in early mammary gland morphogenesis and breast cancer. 

      Howard, B; Ashworth, A (2006-08)
      Specification of mammary epithelial cell fate occurs during embryogenesis as cells aggregate to form the mammary anlage. Within the embryonic mammary bud, a population of epithelial cells exists that will subsequently ...
    • Small-molecule targeting of brachyury transcription factor addiction in chordoma. 

      Sharifnia, T; Wawer, MJ; Chen, T; Huang, Q-Y; Weir, BA; Sizemore, A; Lawlor, MA; Goodale, A; Cowley, GS; Vazquez, F; Ott, CJ; Francis, JM; Sassi, S; Cogswell, P; Sheppard, HE; Zhang, T; Gray, NS; Clarke, PA; Blagg, J; Workman, P; Sommer, J; Hornicek, F; Root, DE; Hahn, WC; Bradner, JE; Wong, KK; Clemons, PA; Lin, CY; Kotz, JD; Schreiber, SL (2019-02)
      Chordoma is a primary bone cancer with no approved therapy<sup>1</sup>. The identification of therapeutic targets in this disease has been challenging due to the infrequent occurrence of clinically actionable somatic ...
    • The BAF and PRC2 Complex Subunits Dpf2 and Eed Antagonistically Converge on Tbx3 to Control ESC Differentiation. 

      Zhang, W; Chronis, C; Chen, X; Zhang, H; Spalinskas, R; Pardo, M; Chen, L; Wu, G; Zhu, Z; Yu, Y; Yu, L; Choudhary, J; Nichols, J; Parast, MM; Greber, B; Sahlén, P; Plath, K (2019-01)
      BAF complexes are composed of different subunits with varying functional and developmental roles, although many subunits have not been examined in depth. Here we show that the Baf45 subunit Dpf2 maintains pluripotency and ...