Now showing items 1-4 of 4

    • Dietary fat and early-onset prostate cancer risk. 

      Lophatananon, A; Archer, J; Easton, D; Pocock, R; Dearnaley, D; Guy, M; Kote-Jarai, Z; O'Brien, L; Wilkinson, RA; Hall, AL; Sawyer, E; Page, E; Liu, J-F; Barratt, S; Rahman, AA; UK Genetic Prostate Cancer Study Collaborators; British Association of Urological Surgeons' Section of Oncology; Eeles, R; Muir, K (2010-05)
      The UK incidence of prostate cancer has been increasing in men aged < 60 years. Migrant studies and global and secular variation in incidence suggest that modifiable factors, including a high-fat diet, may contribute to ...
    • Gene and pathway level analyses of germline DNA-repair gene variants and prostate cancer susceptibility using the iCOGS-genotyping array. 

      Saunders, EJ; Dadaev, T; Leongamornlert, DA; Al Olama, AA; Benlloch, S; Giles, GG; Wiklund, F; Gronberg, H; Haiman, CA; Schleutker, J; Nordestgaard, BG; Travis, RC; Neal, D; Pasayan, N; Khaw, K-T; Stanford, JL; Blot, WJ; Thibodeau, SN; Maier, C; Kibel, AS; Cybulski, C; Cannon-Albright, L; Brenner, H; Park, JY; Kaneva, R; Batra, J; Teixeira, MR; Pandha, H; Govindasami, K; Muir, K; UK Genetic Prostate Cancer Study Collaborators; UK ProtecT Study Collaborators; PRACTICAL Consortium; Easton, DF; Eeles, RA; Kote-Jarai, Z (2016-04)
      Background Germline mutations within DNA-repair genes are implicated in susceptibility to multiple forms of cancer. For prostate cancer (PrCa), rare mutations in BRCA2 and BRCA1 give rise to moderately elevated risk, whereas ...
    • Homeobox B13 G84E Mutation and Prostate Cancer Risk. 

      Nyberg, T; Govindasami, K; Leslie, G; Dadaev, T; Bancroft, E; Ni Raghallaigh, H; Brook, MN; Hussain, N; Keating, D; Lee, A; McMahon, R; Morgan, A; Mullen, A; Osborne, A; Rageevakumar, R; UK Genetic Prostate Cancer Study Collaborators; Kote-Jarai, Z; Eeles, R; Antoniou, AC (2019-05)
      <h4>Background</h4>The homeobox B13 (HOXB13) G84E mutation has been recommended for use in genetic counselling for prostate cancer (PCa), but the magnitude of PCa risk conferred by this mutation is uncertain.<h4>Objective</h4>To ...
    • Use of a Novel Nonparametric Version of DEPTH to Identify Genomic Regions Associated with Prostate Cancer Risk. 

      MacInnis, RJ; Schmidt, DF; Makalic, E; Severi, G; FitzGerald, LM; Reumann, M; Kapuscinski, MK; Kowalczyk, A; Zhou, Z; Goudey, B; Qian, G; Bui, QM; Park, DJ; Freeman, A; Southey, MC; Al Olama, AA; Kote-Jarai, Z; Eeles, RA; Hopper, JL; Giles, GG; UK Genetic Prostate Cancer Study Collaborators (2016-12)
      Background We have developed a genome-wide association study analysis method called DEPTH (DEPendency of association on the number of Top Hits) to identify genomic regions potentially associated with disease by considering ...