Now showing items 1-2 of 2

    • Mechanism of activation of the RAF-ERK signaling pathway by oncogenic mutations of B-RAF. 

      Wan, PTC; Garnett, MJ; Roe, SM; Lee, S; Niculescu-Duvaz, D; Good, VM; Jones, CM; Marshall, CJ; Springer, CJ; Barford, D; Marais, R; Cancer Genome Project (2004-03)
      Over 30 mutations of the B-RAF gene associated with human cancers have been identified, the majority of which are located within the kinase domain. Here we show that of 22 B-RAF mutants analyzed, 18 have elevated kinase ...
    • Structural basis for the inhibition of cGAS by nucleosomes. 

      Kujirai, T; Zierhut, C; Takizawa, Y; Kim, R; Negishi, L; Uruma, N; Hirai, S; Funabiki, H; Kurumizaka, H (2020-10)
      The cyclic guanosine monophosphate-adenosine monophosphate synthase (cGAS) senses invasion of pathogenic DNA and stimulates inflammatory signaling, autophagy, and apoptosis. Organization of host DNA into nucleosomes was ...