Now showing items 1-3 of 3

    • ChEMBL: a large-scale bioactivity database for drug discovery. 

      Gaulton, A; Bellis, LJ; Bento, AP; Chambers, J; Davies, M; Hersey, A; Light, Y; McGlinchey, S; Michalovich, D; Al-Lazikani, B; Overington, JP (2012-01)
      ChEMBL is an Open Data database containing binding, functional and ADMET information for a large number of drug-like bioactive compounds. These data are manually abstracted from the primary published literature on a regular ...
    • MoKCa database--mutations of kinases in cancer. 

      Richardson, CJ; Gao, Q; Mitsopoulous, C; Zvelebil, M; Pearl, LH; Pearl, FM (2009-01)
      Members of the protein kinase family are amongst the most commonly mutated genes in human cancer, and both mutated and activated protein kinases have proved to be tractable targets for the development of new anticancer ...
    • Structure-based drug design: aiming for a perfect fit. 

      van Montfort, RLM; Workman, P (2017-11-08)
      Knowledge of the three-dimensional structure of therapeutically relevant targets has informed drug discovery since the first protein structures were determined using X-ray crystallography in the 1950s and 1960s. In this ...