Now showing items 1-2 of 2

    • Genetic and regulatory mechanism of susceptibility to high-hyperdiploid acute lymphoblastic leukaemia at 10p21.2. 

      Studd, JB; Vijayakrishnan, J; Yang, M; Migliorini, G; Paulsson, K; Houlston, RS (2017-03-03)
      Despite high-hyperdiploid acute lymphoblastic leukaemia (HD-ALL) being the most common subgroup of paediatric ALL, its aetiology remains unknown. Genome-wide association studies have demonstrated association at 10q21.2. ...
    • Genetic Predisposition to Multiple Myeloma at 5q15 Is Mediated by an ELL2 Enhancer Polymorphism. 

      Li, N; Johnson, DC; Weinhold, N; Kimber, S; Dobbins, SE; Mitchell, JS; Kinnersley, B; Sud, A; Law, PJ; Orlando, G; Scales, M; Wardell, CP; Försti, A; Hoang, PH; Went, M; Holroyd, A; Hariri, F; Pastinen, T; Meissner, T; Goldschmidt, H; Hemminki, K; Morgan, GJ; Kaiser, M; Houlston, RS (2017-09-12)
      Multiple myeloma (MM) is a malignancy of plasma cells. Genome-wide association studies have shown that variation at 5q15 influences MM risk. Here, we have sought to decipher the causal variant at 5q15 and the mechanism by ...