Now showing items 1-2 of 2

    • Over-expression of the miR-483-3p overcomes the miR-145/TP53 pro-apoptotic loop in hepatocellular carcinoma. 

      Lupini, L; Pepe, F; Ferracin, M; Braconi, C; Callegari, E; Pagotto, S; Spizzo, R; Zagatti, B; Lanuti, P; Fornari, F; Ghasemi, R; Mariani-Costantini, R; Bolondi, L; Gramantieri, L; Calin, GA; Sabbioni, S; Visone, R; Veronese, A; Negrini, M (2016-05)
      The miR-145-5p, which induces TP53-dependent apoptosis, is down-regulated in several tumors, including hepatocellular carcinomas (HCCs), but some HCCs show physiological expression of this miR. Here we demonstrate that in ...
    • Promoter capture Hi-C-based identification of recurrent noncoding mutations in colorectal cancer. 

      Orlando, G; Law, PJ; Cornish, AJ; Dobbins, SE; Chubb, D; Broderick, P; Litchfield, K; Hariri, F; Pastinen, T; Osborne, CS; Taipale, J; Houlston, RS (2018-10)
      Efforts are being directed to systematically analyze the non-coding regions of the genome for cancer-driving mutations1-6. cis-regulatory elements (CREs) represent a highly enriched subset of the non-coding regions of the ...