Now showing items 1-2 of 2

    • Mind Bomb Regulates Cell Death during TNF Signaling by Suppressing RIPK1's Cytotoxic Potential. 

      Feltham, R; Jamal, K; Tenev, T; Liccardi, G; Jaco, I; Domingues, CM; Morris, O; John, SW; Annibaldi, A; Widya, M; Kearney, CJ; Clancy, D; Elliott, PR; Glatter, T; Qiao, Q; Thompson, AJ; Nesvizhskii, A; Schmidt, A; Komander, D; Wu, H; Martin, S; Meier, P (2018-04-10)
      Tumor necrosis factor (TNF) is an inflammatory cytokine that can signal cell survival or cell death. The mechanisms that switch between these distinct outcomes remain poorly defined. Here, we show that the E3 ubiquitin ...
    • MK2 Phosphorylates RIPK1 to Prevent TNF-Induced Cell Death. 

      Jaco, I; Annibaldi, A; Lalaoui, N; Wilson, R; Tenev, T; Laurien, L; Kim, C; Jamal, K; Wicky John, S; Liccardi, G; Chau, D; Murphy, JM; Brumatti, G; Feltham, R; Pasparakis, M; Silke, J; Meier, P (2017-06-01)
      TNF is an inflammatory cytokine that upon binding to its receptor, TNFR1, can drive cytokine production, cell survival, or cell death. TNFR1 stimulation causes activation of NF-κB, p38α, and its downstream effector kinase ...