Now showing items 1-3 of 3

    • Dalotuzumab in chemorefractory KRAS exon 2 mutant colorectal cancer: Results from a randomised phase II/III trial. 

      Sclafani, F; Kim, TY; Cunningham, D; Kim, TW; Tabernero, J; Schmoll, HJ; Roh, JK; Kim, SY; Park, YS; Guren, TK; Hawkes, E; Clarke, SJ; Ferry, D; Frodin, J-E; Ayers, M; Nebozhyn, M; Peckitt, C; Loboda, A; Watkins, DJ (2017-01)
      Limited data are available on the efficacy of anti-IGF-1R agents in KRAS mutant colorectal cancer (CRC). We analysed the outcome of 69 chemorefractory, KRAS exon 2 mutant CRC patients who were enrolled in a double-blind, ...
    • IGF1-mediated human embryonic stem cell self-renewal recapitulates the embryonic niche. 

      Wamaitha, SE; Grybel, KJ; Alanis-Lobato, G; Gerri, C; Ogushi, S; McCarthy, A; Mahadevaiah, SK; Healy, L; Lea, RA; Molina-Arcas, M; Devito, LG; Elder, K; Snell, P; Christie, L; Downward, J; Turner, JMA; Niakan, KK (2020-02-07)
      Our understanding of the signalling pathways regulating early human development is limited, despite their fundamental biological importance. Here, we mine transcriptomics datasets to investigate signalling in the human ...
    • Menstrual cycle characteristics and steroid hormone, prolactin, and growth factor levels in premenopausal women. 

      Farland, LV; Mu, F; Eliassen, AH; Hankinson, SE; Tworoger, SS; Barbieri, RL; Dowsett, M; Pollak, MN; Missmer, SA (2017-12)
      Menstrual cycle characteristics are markers of endocrine milieu. However, associations between age at menarche and adulthood sex steroid hormone levels have been inconsistent, and data on menstrual characteristics and ...