Now showing items 1-2 of 2

    • Cell-type-specific eQTL of primary melanocytes facilitates identification of melanoma susceptibility genes. 

      Zhang, T; Choi, J; Kovacs, MA; Shi, J; Xu, M; NISC Comparative Sequencing Program; Melanoma Meta-Analysis Consortium; Goldstein, AM; Trower, AJ; Bishop, DT; Iles, MM; Duffy, DL; MacGregor, S; Amundadottir, LT; Law, MH; Loftus, SK; Pavan, WJ; Brown, KM (2018-11)
      Most expression quantitative trait locus (eQTL) studies to date have been performed in heterogeneous tissues as opposed to specific cell types. To better understand the cell-type-specific regulatory landscape of human ...
    • Multiple myeloma risk variant at 7p15.3 creates an IRF4-binding site and interferes with CDCA7L expression. 

      Li, N; Johnson, DC; Weinhold, N; Studd, JB; Orlando, G; Mirabella, F; Mitchell, JS; Meissner, T; Kaiser, M; Goldschmidt, H; Hemminki, K; Morgan, GJ; Houlston, RS (2016-11-24)
      Genome-wide association studies have identified several risk loci for multiple myeloma (MM); however, the mechanisms by which they influence MM are unknown. Here by using genetic association data and functional characterization, ...