Browsing by subject "Interferons"
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Suppression of interferon gene expression overcomes resistance to MEK inhibition in KRAS-mutant colorectal cancer. (2019-03)Despite showing clinical activity in BRAF-mutant melanoma, the MEK inhibitor (MEKi) trametinib has failed to show clinical benefit in KRAS-mutant colorectal cancer. To identify mechanisms of resistance to MEKi, we employed ...