Now showing items 1-5 of 5

    • Docetaxel Treatment in PTEN- and ERG-aberrant Metastatic Prostate Cancers. 

      Rescigno, P; Lorente, D; Dolling, D; Ferraldeschi, R; Rodrigues, DN; Riisnaes, R; Miranda, S; Bianchini, D; Zafeiriou, Z; Sideris, S; Ferreira, A; Figueiredo, I; Sumanasuriya, S; Mateo, J; Perez-Lopez, R; Sharp, A; Tunariu, N; de Bono, JS (2018-05)
      Background: Loss of PTEN is a common genomic aberration in castration-resistant prostate cancer (CRPC) and is frequently concurrent with ERG rearrangements, causing resistance to next-generation hormonal treatment (NGHT) ...
    • PARK2 Depletion Connects Energy and Oxidative Stress to PI3K/Akt Activation via PTEN S-Nitrosylation. 

      Gupta, A; Anjomani-Virmouni, S; Koundouros, N; Dimitriadi, M; Choo-Wing, R; Valle, A; Zheng, Y; Chiu, Y-H; Agnihotri, S; Zadeh, G; Asara, JM; Anastasiou, D; Arends, MJ; Cantley, LC; Poulogiannis, G (2017-03-16)
      PARK2 is a gene implicated in disease states with opposing responses in cell fate determination, yet its contribution in pro-survival signaling is largely unknown. Here we show that PARK2 is altered in over a third of all ...
    • PARK2 loss promotes cancer progression via redox-mediated inactivation of PTEN. 

      Gupta, A; Anjomani-Virmouni, S; Koundouros, N; Poulogiannis, G (2017)
      Cancer and Parkinson disease (PD) derive from distinct alterations in cellular processes, yet there are pathogenic mutations that are unequivocally linked to both diseases. Here we expand on our recent findings that loss ...
    • Preclinical evaluation of the PARP inhibitor BMN-673 for the treatment of ovarian clear cell cancer. 

      Wilkerson, PM; Dedes, KJ; Samartzis, EP; Dedes, I; Lambros, MB; Natrajan, R; Gauthier, A; Piscuoglio, S; Töpfer, C; Vukovic, V; Daley, F; Weigelt, B; Reis-Filho, JS (2017-01-24)
      PURPOSE: To determine if models of ovarian clear cell carcinomas (OCCCs) harbouring defects in homologous recombination (HR) DNA repair of double strand breaks (DSBs) are sensitive to cisplatin and/or PARP inhibition. ...
    • Targeting the PI3-kinase pathway in triple-negative breast cancer. 

      Pascual, J; Turner, NC (2019-07-01)
      Triple-negative breast cancer (TNBC) is characterised by poor outcomes and a historical lack of targeted therapies. Dysregulation of signalling through the phosphoinositide 3 (PI3)-kinase and AKT signalling pathway is one ...