Now showing items 1-7 of 7

    • canSAR: updated cancer research and drug discovery knowledgebase. 

      Bulusu, KC; Tym, JE; Coker, EA; Schierz, AC; Al-Lazikani, B (2014-01)
      canSAR (http://cansar.icr.ac.uk) is a public integrative cancer-focused knowledgebase for the support of cancer translational research and drug discovery. Through the integration of biological, pharmacological, chemical, ...
    • ChEMBL: a large-scale bioactivity database for drug discovery. 

      Gaulton, A; Bellis, LJ; Bento, AP; Chambers, J; Davies, M; Hersey, A; Light, Y; McGlinchey, S; Michalovich, D; Al-Lazikani, B; Overington, JP (2012-01)
      ChEMBL is an Open Data database containing binding, functional and ADMET information for a large number of drug-like bioactive compounds. These data are manually abstracted from the primary published literature on a regular ...
    • Donated chemical probes for open science. 

      Müller, S; Ackloo, S; Arrowsmith, CH; Bauser, M; Baryza, JL; Blagg, J; Böttcher, J; Bountra, C; Brown, PJ; Bunnage, ME; Carter, AJ; Damerell, D; Dötsch, V; Drewry, DH; Edwards, AM; Edwards, J; Elkins, JM; Fischer, C; Frye, SV; Gollner, A; Grimshaw, CE; IJzerman, A; Hanke, T; Hartung, IV; Hitchcock, S; Howe, T; Hughes, TV; Laufer, S; Li, VM; Liras, S; Marsden, BD; Matsui, H; Mathias, J; O'Hagan, RC; Owen, DR; Pande, V; Rauh, D; Rosenberg, SH; Roth, BL; Schneider, NS; Scholten, C; Singh Saikatendu, K; Simeonov, A; Takizawa, M; Tse, C; Thompson, PR; Treiber, DK; Viana, AY; Wells, CI; Willson, TM; Zuercher, WJ; Knapp, S; Mueller-Fahrnow, A (2018-04-20)
      Potent, selective and broadly characterized small molecule modulators of protein function (chemical probes) are powerful research reagents. The pharmaceutical industry has generated many high-quality chemical probes and ...
    • Recurrent MET fusion genes represent a drug target in pediatric glioblastoma. 

      International Cancer Genome Consortium PedBrain Tumor Project (2016-11)
      Pediatric glioblastoma is one of the most common and most deadly brain tumors in childhood. Using an integrative genetic analysis of 53 pediatric glioblastomas and five in vitro model systems, we identified previously ...
    • SiGNet: A signaling network data simulator to enable signaling network inference. 

      Coker, EA; Mitsopoulos, C; Workman, P; Al-Lazikani, B (2017)
      Network models are widely used to describe complex signaling systems. Cellular wiring varies in different cellular contexts and numerous inference techniques have been developed to infer the structure of a network from ...
    • Structure-based drug design: aiming for a perfect fit. 

      van Montfort, RLM; Workman, P (2017-11-08)
      Knowledge of the three-dimensional structure of therapeutically relevant targets has informed drug discovery since the first protein structures were determined using X-ray crystallography in the 1950s and 1960s. In this ...
    • Systematic evaluation of quantotypic peptides for targeted analysis of the human kinome. 

      Worboys, JD; Sinclair, J; Yuan, Y; Jørgensen, C (2014-10)
      In targeted proteomics it is critical that peptides are not only proteotypic but also accurately represent the level of the protein (quantotypic). Numerous approaches are used to identify proteotypic peptides, but quantotypic ...